In the Absence of a TCR Signal IL-2/IL-12/18-Stimulated γδ T Cells Demonstrate Potent Anti-Tumoral Function Through Direct Killing and Senescence Induction in Cancer Cells

Abundant IFN-γ secretion, potent cytotoxicity, and major histocompatibility complex-independent targeting of a large spectrum of tumors make γδ T cells attractive candidates for cancer immunotherapy. Upon tumor recognition through the T-cell receptor (TCR), NK-receptors, or NKG2D, γδ T cells generat...

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Detalles Bibliográficos
Autores principales: Schilbach, Karin, Welker, Christian, Krickeberg, Naomi, Kaißer, Carlotta, Schleicher, Sabine, Hashimoto, Hisayoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017313/
https://www.ncbi.nlm.nih.gov/pubmed/31947966
http://dx.doi.org/10.3390/cancers12010130

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017313/
https://www.ncbi.nlm.nih.gov/pubmed/31947966
http://dx.doi.org/10.3390/cancers12010130

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