Connecting Cancer Pathways to Tumor Engines: A Stratification Tool for Colorectal Cancer Combining Human In Vitro Tissue Models with Boolean In Silico Models

To improve and focus preclinical testing, we combine tumor models based on a decellularized tissue matrix with bioinformatics to stratify tumors according to stage-specific mutations that are linked to central cancer pathways. We generated tissue models with BRAF-mutant colorectal cancer (CRC) cells...

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Detalles Bibliográficos
Autores principales: Baur, Florentin, Nietzer, Sarah L., Kunz, Meik, Saal, Fabian, Jeromin, Julian, Matschos, Stephanie, Linnebacher, Michael, Walles, Heike, Dandekar, Thomas, Dandekar, Gudrun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017315/
https://www.ncbi.nlm.nih.gov/pubmed/31861874
http://dx.doi.org/10.3390/cancers12010028

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