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Agonist Antibody Converts Stem Cells into Migrating Brown Adipocyte-Like Cells in Heart
We present data showing that Iodotyrosine Deiodinase (IYD) is a dual-function enzyme acting as a catalyst in metabolism and a receptor for cooperative stem cell differentiation. IYD is present both in thyroid cells where it is critical for scavenging iodine from halogenated by-products of thyroid ho...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017361/ https://www.ncbi.nlm.nih.gov/pubmed/31968623 http://dx.doi.org/10.3390/cells9010256 |
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author | Han, Kyung Ho Arlian, Britni M. Lin, Chih-Wei Jin, Hyun Yong Kang, Geun-Hyung Lee, Sahmin Lee, Peter Chang-Whan Lerner, Richard A. |
author_facet | Han, Kyung Ho Arlian, Britni M. Lin, Chih-Wei Jin, Hyun Yong Kang, Geun-Hyung Lee, Sahmin Lee, Peter Chang-Whan Lerner, Richard A. |
author_sort | Han, Kyung Ho |
collection | PubMed |
description | We present data showing that Iodotyrosine Deiodinase (IYD) is a dual-function enzyme acting as a catalyst in metabolism and a receptor for cooperative stem cell differentiation. IYD is present both in thyroid cells where it is critical for scavenging iodine from halogenated by-products of thyroid hormone production and on hematopoietic stem cells. To close the cooperative loop, the mono- and di-Iodotyrosine (MIT and DIT) substrates of IYD in the thyroid are also agonists for IYD now acting as a receptor on bone marrow stem cells. While studying intracellular combinatorial antibody libraries, we discovered an agonist antibody, H3 Ab, of which the target is the enzyme IYD. When agonized by H3 Ab, IYD expressed on stem cells induces differentiation of the cells into brown adipocyte-like cells, which selectively migrate to mouse heart tissue. H3 Ab also binds to IYD expressed on human myocardium. Thus, one has a single enzyme acting in different ways on different cells for the cooperative purpose of enhancing thermogenesis or of regenerating damaged heart tissue. |
format | Online Article Text |
id | pubmed-7017361 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-70173612020-02-28 Agonist Antibody Converts Stem Cells into Migrating Brown Adipocyte-Like Cells in Heart Han, Kyung Ho Arlian, Britni M. Lin, Chih-Wei Jin, Hyun Yong Kang, Geun-Hyung Lee, Sahmin Lee, Peter Chang-Whan Lerner, Richard A. Cells Article We present data showing that Iodotyrosine Deiodinase (IYD) is a dual-function enzyme acting as a catalyst in metabolism and a receptor for cooperative stem cell differentiation. IYD is present both in thyroid cells where it is critical for scavenging iodine from halogenated by-products of thyroid hormone production and on hematopoietic stem cells. To close the cooperative loop, the mono- and di-Iodotyrosine (MIT and DIT) substrates of IYD in the thyroid are also agonists for IYD now acting as a receptor on bone marrow stem cells. While studying intracellular combinatorial antibody libraries, we discovered an agonist antibody, H3 Ab, of which the target is the enzyme IYD. When agonized by H3 Ab, IYD expressed on stem cells induces differentiation of the cells into brown adipocyte-like cells, which selectively migrate to mouse heart tissue. H3 Ab also binds to IYD expressed on human myocardium. Thus, one has a single enzyme acting in different ways on different cells for the cooperative purpose of enhancing thermogenesis or of regenerating damaged heart tissue. MDPI 2020-01-20 /pmc/articles/PMC7017361/ /pubmed/31968623 http://dx.doi.org/10.3390/cells9010256 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Han, Kyung Ho Arlian, Britni M. Lin, Chih-Wei Jin, Hyun Yong Kang, Geun-Hyung Lee, Sahmin Lee, Peter Chang-Whan Lerner, Richard A. Agonist Antibody Converts Stem Cells into Migrating Brown Adipocyte-Like Cells in Heart |
title | Agonist Antibody Converts Stem Cells into Migrating Brown Adipocyte-Like Cells in Heart |
title_full | Agonist Antibody Converts Stem Cells into Migrating Brown Adipocyte-Like Cells in Heart |
title_fullStr | Agonist Antibody Converts Stem Cells into Migrating Brown Adipocyte-Like Cells in Heart |
title_full_unstemmed | Agonist Antibody Converts Stem Cells into Migrating Brown Adipocyte-Like Cells in Heart |
title_short | Agonist Antibody Converts Stem Cells into Migrating Brown Adipocyte-Like Cells in Heart |
title_sort | agonist antibody converts stem cells into migrating brown adipocyte-like cells in heart |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017361/ https://www.ncbi.nlm.nih.gov/pubmed/31968623 http://dx.doi.org/10.3390/cells9010256 |
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