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Enhancement of bleomycin production in Streptomyces verticillus through global metabolic regulation of N-acetylglucosamine and assisted metabolic profiling analysis

BACKGROUND: Bleomycin is a broad-spectrum glycopeptide antitumor antibiotic produced by Streptomyces verticillus. Clinically, the mixture of bleomycin A2 and bleomycin B2 is widely used in combination with other drugs for the treatment of various cancers. As a secondary metabolite, the biosynthesis...

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Detalles Bibliográficos
Autores principales:	Chen, Hong, Cui, Jiaqi, Wang, Pan, Wang, Xin, Wen, Jianping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017467/ https://www.ncbi.nlm.nih.gov/pubmed/32054531 http://dx.doi.org/10.1186/s12934-020-01301-8

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