The efficacy of DNA mismatch repair enzyme immunohistochemistry as a screening test for hypermutated gliomas

A subset of gliomas has DNA repair defects that lead to hypermutated genomes. While such tumors are resistant to alkylating chemotherapies, they may also express more mutant neoantigens on their cell surfaces, and thus be more responsive to immunotherapies. A fast, inexpensive method of screening fo...

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Detalles Bibliográficos
Autores principales: McCord, Matthew, Steffens, Alicia, Javier, Rodrigo, Kam, Kwok-Ling, McCortney, Kathleen, Horbinski, Craig
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017562/
https://www.ncbi.nlm.nih.gov/pubmed/32051040
http://dx.doi.org/10.1186/s40478-020-0892-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017562/
https://www.ncbi.nlm.nih.gov/pubmed/32051040
http://dx.doi.org/10.1186/s40478-020-0892-2

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