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Thickness of individual layers at the macula and associated factors: the Beijing Eye Study 2011

BACKGROUND: Diagnosis and follow-up of retinal diseases may be improved if the thickness of the various retinal layers, in addition to the total retinal thickness, is taken into account. Here we measured the thickness of the macular retinal layers in a population-based study group to assess the norm...

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Autores principales: Wang, Qian, Wei, Wen Bin, Wang, Ya Xing, Yan, Yan Ni, Yang, Jing Yan, Zhou, Wen Jia, Chan, Szy Yann, Xu, Liang, Jonas, Jost B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017623/
https://www.ncbi.nlm.nih.gov/pubmed/32050936
http://dx.doi.org/10.1186/s12886-019-1296-6
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author Wang, Qian
Wei, Wen Bin
Wang, Ya Xing
Yan, Yan Ni
Yang, Jing Yan
Zhou, Wen Jia
Chan, Szy Yann
Xu, Liang
Jonas, Jost B.
author_facet Wang, Qian
Wei, Wen Bin
Wang, Ya Xing
Yan, Yan Ni
Yang, Jing Yan
Zhou, Wen Jia
Chan, Szy Yann
Xu, Liang
Jonas, Jost B.
author_sort Wang, Qian
collection PubMed
description BACKGROUND: Diagnosis and follow-up of retinal diseases may be improved if the thickness of the various retinal layers, in addition to the total retinal thickness, is taken into account. Here we measured the thickness of the macular retinal layers in a population-based study group to assess the normative values and their associations. METHODS: Using spectral-domain optical coherence tomographic images (Spectralis®, wavelength: 870 nm; Heidelberg Engineering Co, Heidelberg, Germany), we measured the thickness of the macular retinal layers in participants of the population-based Beijing Eye Study without ocular diseases and without systematic diseases, such as arterial hypertension, hyperlipidemia, diabetes mellitus, cardiovascular diseases, previous myocardial infarction, cerebral trauma and stroke. Segmentation and measurement of the retinal layers was performed automatically in each of the horizontal scans. RESULTS: The study included 384 subjects (mean age:60.0 ± 8.0 years). The mean thickness of the whole retina, outer plexiform layer, outer nuclear layer,retinal pigment epithelium, inner retinal layer and photoreceptor layer was 259.8 ± 18.9 μm, 19.4 ± 3.9 μm, 93.4 ± 9.6 μm, 17.6 ± 1.9 μm, 169.8 ± 18.6 μm, and 90.0 ± 4.2 μm, respectively. In multivariable analysis, the thickness of the foveola and of all retinal layers in the foveal, parafoveal and perifoveal region decreased with older age (all P < 0.05), except for the thickness of the parafoveal outer plexiform layer which increased with age. Men as compared to women had higher thickness measurements of the photoreceptor layer and outer nuclear layer in all areas, and of all layers between the retinal nerve fiber layer and inner nuclear layer in the parafoveal area (all P < 0.05). The associations between the macular retinal layers thickness and axial length were not consistent. The inner plexiform layer was thicker, and the ganglion cell layer and inner nuclear layer were thinner, in the temporal areas than in the nasal areas, CONCLUSIONS: The associations between decreasing thickness of most retinal layers with older age and the correlation of a higher thickness of some retinal layers with male gender may clinically be taken into account.
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spelling pubmed-70176232020-02-20 Thickness of individual layers at the macula and associated factors: the Beijing Eye Study 2011 Wang, Qian Wei, Wen Bin Wang, Ya Xing Yan, Yan Ni Yang, Jing Yan Zhou, Wen Jia Chan, Szy Yann Xu, Liang Jonas, Jost B. BMC Ophthalmol Research Article BACKGROUND: Diagnosis and follow-up of retinal diseases may be improved if the thickness of the various retinal layers, in addition to the total retinal thickness, is taken into account. Here we measured the thickness of the macular retinal layers in a population-based study group to assess the normative values and their associations. METHODS: Using spectral-domain optical coherence tomographic images (Spectralis®, wavelength: 870 nm; Heidelberg Engineering Co, Heidelberg, Germany), we measured the thickness of the macular retinal layers in participants of the population-based Beijing Eye Study without ocular diseases and without systematic diseases, such as arterial hypertension, hyperlipidemia, diabetes mellitus, cardiovascular diseases, previous myocardial infarction, cerebral trauma and stroke. Segmentation and measurement of the retinal layers was performed automatically in each of the horizontal scans. RESULTS: The study included 384 subjects (mean age:60.0 ± 8.0 years). The mean thickness of the whole retina, outer plexiform layer, outer nuclear layer,retinal pigment epithelium, inner retinal layer and photoreceptor layer was 259.8 ± 18.9 μm, 19.4 ± 3.9 μm, 93.4 ± 9.6 μm, 17.6 ± 1.9 μm, 169.8 ± 18.6 μm, and 90.0 ± 4.2 μm, respectively. In multivariable analysis, the thickness of the foveola and of all retinal layers in the foveal, parafoveal and perifoveal region decreased with older age (all P < 0.05), except for the thickness of the parafoveal outer plexiform layer which increased with age. Men as compared to women had higher thickness measurements of the photoreceptor layer and outer nuclear layer in all areas, and of all layers between the retinal nerve fiber layer and inner nuclear layer in the parafoveal area (all P < 0.05). The associations between the macular retinal layers thickness and axial length were not consistent. The inner plexiform layer was thicker, and the ganglion cell layer and inner nuclear layer were thinner, in the temporal areas than in the nasal areas, CONCLUSIONS: The associations between decreasing thickness of most retinal layers with older age and the correlation of a higher thickness of some retinal layers with male gender may clinically be taken into account. BioMed Central 2020-02-12 /pmc/articles/PMC7017623/ /pubmed/32050936 http://dx.doi.org/10.1186/s12886-019-1296-6 Text en © The Author(s). 2020 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Wang, Qian
Wei, Wen Bin
Wang, Ya Xing
Yan, Yan Ni
Yang, Jing Yan
Zhou, Wen Jia
Chan, Szy Yann
Xu, Liang
Jonas, Jost B.
Thickness of individual layers at the macula and associated factors: the Beijing Eye Study 2011
title Thickness of individual layers at the macula and associated factors: the Beijing Eye Study 2011
title_full Thickness of individual layers at the macula and associated factors: the Beijing Eye Study 2011
title_fullStr Thickness of individual layers at the macula and associated factors: the Beijing Eye Study 2011
title_full_unstemmed Thickness of individual layers at the macula and associated factors: the Beijing Eye Study 2011
title_short Thickness of individual layers at the macula and associated factors: the Beijing Eye Study 2011
title_sort thickness of individual layers at the macula and associated factors: the beijing eye study 2011
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017623/
https://www.ncbi.nlm.nih.gov/pubmed/32050936
http://dx.doi.org/10.1186/s12886-019-1296-6
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