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Codon and amino acid content are associated with mRNA stability in mammalian cells

Messenger RNA (mRNA) degradation plays a critical role in regulating transcript levels in the cell and is a major control point for modulating gene expression. In yeast and other model organisms, codon identity is a powerful determinant of transcript stability, contributing broadly to impact half-li...

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Detalles Bibliográficos
Autores principales:	Forrest, Megan E., Pinkard, Otis, Martin, Sophie, Sweet, Thomas J., Hanson, Gavin, Coller, Jeff
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018022/ https://www.ncbi.nlm.nih.gov/pubmed/32053646 http://dx.doi.org/10.1371/journal.pone.0228730

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