Cargando…

Association between higher urinary normetanephrine and insulin resistance in a Japanese population

Since activation of the sympathetic nervous system is associated with both impaired insulin secretion and insulin resistance, or namely with diabetes, evaluation of such activation in ordinary clinical settings may be important. Therefore, we evaluated the relationships between urinary concentration...

Descripción completa

Detalles Bibliográficos
Autores principales: Murabayashi, Masaya, Daimon, Makoto, Murakami, Hiroshi, Fujita, Tomoyuki, Sato, Eri, Tanabe, Jutaro, Matsuhashi, Yuki, Takayasu, Shinobu, Yanagimachi, Miyuki, Terui, Ken, Kageyama, Kazunori, Tokuda, Itoyo, Sawada, Kaori, Ihara, Kazushige
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018048/
https://www.ncbi.nlm.nih.gov/pubmed/32053635
http://dx.doi.org/10.1371/journal.pone.0228787
_version_ 1783497293510475776
author Murabayashi, Masaya
Daimon, Makoto
Murakami, Hiroshi
Fujita, Tomoyuki
Sato, Eri
Tanabe, Jutaro
Matsuhashi, Yuki
Takayasu, Shinobu
Yanagimachi, Miyuki
Terui, Ken
Kageyama, Kazunori
Tokuda, Itoyo
Sawada, Kaori
Ihara, Kazushige
author_facet Murabayashi, Masaya
Daimon, Makoto
Murakami, Hiroshi
Fujita, Tomoyuki
Sato, Eri
Tanabe, Jutaro
Matsuhashi, Yuki
Takayasu, Shinobu
Yanagimachi, Miyuki
Terui, Ken
Kageyama, Kazunori
Tokuda, Itoyo
Sawada, Kaori
Ihara, Kazushige
author_sort Murabayashi, Masaya
collection PubMed
description Since activation of the sympathetic nervous system is associated with both impaired insulin secretion and insulin resistance, or namely with diabetes, evaluation of such activation in ordinary clinical settings may be important. Therefore, we evaluated the relationships between urinary concentrations of the catecholamine metabolites, urinary normetanephrine (U-NM) and urinary metanephrine (U-M), and glucose metabolism in a general population. From 1,148 participants in the 2016 population-based Iwaki study of Japanese, enrolled were 733 individuals (gender (M/F): 320/413; age: 52.1±15.1), who were not on medication affecting serum catecholamines, not diabetic, and had complete data-set and blood glucose levels appropriate for the evaluation of insulin secretion and resistance, using homeostasis model assessment (HOMA-β and HOMA-R, respectively). Univariate linear regression analyses revealed significant correlations between both U-NM and U-M, and HOMA-β, but adjustment for multiple factors correlated with HOMA indices abolished these (β = -0.031, p = 0.499, and β = -0.055, p = 0.135, respectively). However, the correlation between U-NM and HOMA-R observed using univariate linear regression analysis (β = 0.132, p<0.001) remained significant even after these adjustments (β = 0.107, p = 0.007), whereas U-M did not correlate with HOMA-R. Furthermore, use of the optimal cut-off value of U-NM for the prediction of insulin resistance (HOMA-R >1.6) determined by ROC analysis (0.2577 mg/gCr) showed that individuals at risk had an odds ratio of 2.65 (confidence interval: 1.42–4.97) after adjustment for the same factors used above. Higher U-NM concentrations within the physiologic range are a significant risk factor for increased insulin resistance in a general Japanese population.
format Online
Article
Text
id pubmed-7018048
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-70180482020-02-26 Association between higher urinary normetanephrine and insulin resistance in a Japanese population Murabayashi, Masaya Daimon, Makoto Murakami, Hiroshi Fujita, Tomoyuki Sato, Eri Tanabe, Jutaro Matsuhashi, Yuki Takayasu, Shinobu Yanagimachi, Miyuki Terui, Ken Kageyama, Kazunori Tokuda, Itoyo Sawada, Kaori Ihara, Kazushige PLoS One Research Article Since activation of the sympathetic nervous system is associated with both impaired insulin secretion and insulin resistance, or namely with diabetes, evaluation of such activation in ordinary clinical settings may be important. Therefore, we evaluated the relationships between urinary concentrations of the catecholamine metabolites, urinary normetanephrine (U-NM) and urinary metanephrine (U-M), and glucose metabolism in a general population. From 1,148 participants in the 2016 population-based Iwaki study of Japanese, enrolled were 733 individuals (gender (M/F): 320/413; age: 52.1±15.1), who were not on medication affecting serum catecholamines, not diabetic, and had complete data-set and blood glucose levels appropriate for the evaluation of insulin secretion and resistance, using homeostasis model assessment (HOMA-β and HOMA-R, respectively). Univariate linear regression analyses revealed significant correlations between both U-NM and U-M, and HOMA-β, but adjustment for multiple factors correlated with HOMA indices abolished these (β = -0.031, p = 0.499, and β = -0.055, p = 0.135, respectively). However, the correlation between U-NM and HOMA-R observed using univariate linear regression analysis (β = 0.132, p<0.001) remained significant even after these adjustments (β = 0.107, p = 0.007), whereas U-M did not correlate with HOMA-R. Furthermore, use of the optimal cut-off value of U-NM for the prediction of insulin resistance (HOMA-R >1.6) determined by ROC analysis (0.2577 mg/gCr) showed that individuals at risk had an odds ratio of 2.65 (confidence interval: 1.42–4.97) after adjustment for the same factors used above. Higher U-NM concentrations within the physiologic range are a significant risk factor for increased insulin resistance in a general Japanese population. Public Library of Science 2020-02-13 /pmc/articles/PMC7018048/ /pubmed/32053635 http://dx.doi.org/10.1371/journal.pone.0228787 Text en © 2020 Murabayashi et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Murabayashi, Masaya
Daimon, Makoto
Murakami, Hiroshi
Fujita, Tomoyuki
Sato, Eri
Tanabe, Jutaro
Matsuhashi, Yuki
Takayasu, Shinobu
Yanagimachi, Miyuki
Terui, Ken
Kageyama, Kazunori
Tokuda, Itoyo
Sawada, Kaori
Ihara, Kazushige
Association between higher urinary normetanephrine and insulin resistance in a Japanese population
title Association between higher urinary normetanephrine and insulin resistance in a Japanese population
title_full Association between higher urinary normetanephrine and insulin resistance in a Japanese population
title_fullStr Association between higher urinary normetanephrine and insulin resistance in a Japanese population
title_full_unstemmed Association between higher urinary normetanephrine and insulin resistance in a Japanese population
title_short Association between higher urinary normetanephrine and insulin resistance in a Japanese population
title_sort association between higher urinary normetanephrine and insulin resistance in a japanese population
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018048/
https://www.ncbi.nlm.nih.gov/pubmed/32053635
http://dx.doi.org/10.1371/journal.pone.0228787
work_keys_str_mv AT murabayashimasaya associationbetweenhigherurinarynormetanephrineandinsulinresistanceinajapanesepopulation
AT daimonmakoto associationbetweenhigherurinarynormetanephrineandinsulinresistanceinajapanesepopulation
AT murakamihiroshi associationbetweenhigherurinarynormetanephrineandinsulinresistanceinajapanesepopulation
AT fujitatomoyuki associationbetweenhigherurinarynormetanephrineandinsulinresistanceinajapanesepopulation
AT satoeri associationbetweenhigherurinarynormetanephrineandinsulinresistanceinajapanesepopulation
AT tanabejutaro associationbetweenhigherurinarynormetanephrineandinsulinresistanceinajapanesepopulation
AT matsuhashiyuki associationbetweenhigherurinarynormetanephrineandinsulinresistanceinajapanesepopulation
AT takayasushinobu associationbetweenhigherurinarynormetanephrineandinsulinresistanceinajapanesepopulation
AT yanagimachimiyuki associationbetweenhigherurinarynormetanephrineandinsulinresistanceinajapanesepopulation
AT teruiken associationbetweenhigherurinarynormetanephrineandinsulinresistanceinajapanesepopulation
AT kageyamakazunori associationbetweenhigherurinarynormetanephrineandinsulinresistanceinajapanesepopulation
AT tokudaitoyo associationbetweenhigherurinarynormetanephrineandinsulinresistanceinajapanesepopulation
AT sawadakaori associationbetweenhigherurinarynormetanephrineandinsulinresistanceinajapanesepopulation
AT iharakazushige associationbetweenhigherurinarynormetanephrineandinsulinresistanceinajapanesepopulation