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Association between higher urinary normetanephrine and insulin resistance in a Japanese population
Since activation of the sympathetic nervous system is associated with both impaired insulin secretion and insulin resistance, or namely with diabetes, evaluation of such activation in ordinary clinical settings may be important. Therefore, we evaluated the relationships between urinary concentration...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018048/ https://www.ncbi.nlm.nih.gov/pubmed/32053635 http://dx.doi.org/10.1371/journal.pone.0228787 |
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author | Murabayashi, Masaya Daimon, Makoto Murakami, Hiroshi Fujita, Tomoyuki Sato, Eri Tanabe, Jutaro Matsuhashi, Yuki Takayasu, Shinobu Yanagimachi, Miyuki Terui, Ken Kageyama, Kazunori Tokuda, Itoyo Sawada, Kaori Ihara, Kazushige |
author_facet | Murabayashi, Masaya Daimon, Makoto Murakami, Hiroshi Fujita, Tomoyuki Sato, Eri Tanabe, Jutaro Matsuhashi, Yuki Takayasu, Shinobu Yanagimachi, Miyuki Terui, Ken Kageyama, Kazunori Tokuda, Itoyo Sawada, Kaori Ihara, Kazushige |
author_sort | Murabayashi, Masaya |
collection | PubMed |
description | Since activation of the sympathetic nervous system is associated with both impaired insulin secretion and insulin resistance, or namely with diabetes, evaluation of such activation in ordinary clinical settings may be important. Therefore, we evaluated the relationships between urinary concentrations of the catecholamine metabolites, urinary normetanephrine (U-NM) and urinary metanephrine (U-M), and glucose metabolism in a general population. From 1,148 participants in the 2016 population-based Iwaki study of Japanese, enrolled were 733 individuals (gender (M/F): 320/413; age: 52.1±15.1), who were not on medication affecting serum catecholamines, not diabetic, and had complete data-set and blood glucose levels appropriate for the evaluation of insulin secretion and resistance, using homeostasis model assessment (HOMA-β and HOMA-R, respectively). Univariate linear regression analyses revealed significant correlations between both U-NM and U-M, and HOMA-β, but adjustment for multiple factors correlated with HOMA indices abolished these (β = -0.031, p = 0.499, and β = -0.055, p = 0.135, respectively). However, the correlation between U-NM and HOMA-R observed using univariate linear regression analysis (β = 0.132, p<0.001) remained significant even after these adjustments (β = 0.107, p = 0.007), whereas U-M did not correlate with HOMA-R. Furthermore, use of the optimal cut-off value of U-NM for the prediction of insulin resistance (HOMA-R >1.6) determined by ROC analysis (0.2577 mg/gCr) showed that individuals at risk had an odds ratio of 2.65 (confidence interval: 1.42–4.97) after adjustment for the same factors used above. Higher U-NM concentrations within the physiologic range are a significant risk factor for increased insulin resistance in a general Japanese population. |
format | Online Article Text |
id | pubmed-7018048 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-70180482020-02-26 Association between higher urinary normetanephrine and insulin resistance in a Japanese population Murabayashi, Masaya Daimon, Makoto Murakami, Hiroshi Fujita, Tomoyuki Sato, Eri Tanabe, Jutaro Matsuhashi, Yuki Takayasu, Shinobu Yanagimachi, Miyuki Terui, Ken Kageyama, Kazunori Tokuda, Itoyo Sawada, Kaori Ihara, Kazushige PLoS One Research Article Since activation of the sympathetic nervous system is associated with both impaired insulin secretion and insulin resistance, or namely with diabetes, evaluation of such activation in ordinary clinical settings may be important. Therefore, we evaluated the relationships between urinary concentrations of the catecholamine metabolites, urinary normetanephrine (U-NM) and urinary metanephrine (U-M), and glucose metabolism in a general population. From 1,148 participants in the 2016 population-based Iwaki study of Japanese, enrolled were 733 individuals (gender (M/F): 320/413; age: 52.1±15.1), who were not on medication affecting serum catecholamines, not diabetic, and had complete data-set and blood glucose levels appropriate for the evaluation of insulin secretion and resistance, using homeostasis model assessment (HOMA-β and HOMA-R, respectively). Univariate linear regression analyses revealed significant correlations between both U-NM and U-M, and HOMA-β, but adjustment for multiple factors correlated with HOMA indices abolished these (β = -0.031, p = 0.499, and β = -0.055, p = 0.135, respectively). However, the correlation between U-NM and HOMA-R observed using univariate linear regression analysis (β = 0.132, p<0.001) remained significant even after these adjustments (β = 0.107, p = 0.007), whereas U-M did not correlate with HOMA-R. Furthermore, use of the optimal cut-off value of U-NM for the prediction of insulin resistance (HOMA-R >1.6) determined by ROC analysis (0.2577 mg/gCr) showed that individuals at risk had an odds ratio of 2.65 (confidence interval: 1.42–4.97) after adjustment for the same factors used above. Higher U-NM concentrations within the physiologic range are a significant risk factor for increased insulin resistance in a general Japanese population. Public Library of Science 2020-02-13 /pmc/articles/PMC7018048/ /pubmed/32053635 http://dx.doi.org/10.1371/journal.pone.0228787 Text en © 2020 Murabayashi et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Murabayashi, Masaya Daimon, Makoto Murakami, Hiroshi Fujita, Tomoyuki Sato, Eri Tanabe, Jutaro Matsuhashi, Yuki Takayasu, Shinobu Yanagimachi, Miyuki Terui, Ken Kageyama, Kazunori Tokuda, Itoyo Sawada, Kaori Ihara, Kazushige Association between higher urinary normetanephrine and insulin resistance in a Japanese population |
title | Association between higher urinary normetanephrine and insulin resistance in a Japanese population |
title_full | Association between higher urinary normetanephrine and insulin resistance in a Japanese population |
title_fullStr | Association between higher urinary normetanephrine and insulin resistance in a Japanese population |
title_full_unstemmed | Association between higher urinary normetanephrine and insulin resistance in a Japanese population |
title_short | Association between higher urinary normetanephrine and insulin resistance in a Japanese population |
title_sort | association between higher urinary normetanephrine and insulin resistance in a japanese population |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018048/ https://www.ncbi.nlm.nih.gov/pubmed/32053635 http://dx.doi.org/10.1371/journal.pone.0228787 |
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