Detection and quantification of renal fibrosis by computerized tomography

OBJECTIVES: Reliable biomarkers for renal fibrosis are needed for clinical care and for research. Existing non-invasive biomarkers are imprecise, which has limited their utility. METHODS: We developed a method to quantify fibrosis by subject size-adjusted CT Hounsfield units. This was accomplished u...

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Detalles Bibliográficos
Autores principales: Cohen, Eric P., Olson, John D., Tooze, Janet A., Bourland, J. Daniel, Dugan, Greg O., Cline, J. Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018060/
https://www.ncbi.nlm.nih.gov/pubmed/32053617
http://dx.doi.org/10.1371/journal.pone.0228626
Descripción
Sumario:OBJECTIVES: Reliable biomarkers for renal fibrosis are needed for clinical care and for research. Existing non-invasive biomarkers are imprecise, which has limited their utility. METHODS: We developed a method to quantify fibrosis by subject size-adjusted CT Hounsfield units. This was accomplished using CT measurements of renal cortex in previously irradiated non-human primates. RESULTS: Renal cortex mean CT Hounsfield units that were adjusted for body size had a very good direct correlation with renal parenchymal fibrosis, with an area under the curve of 0.93. CONCLUSIONS: This metric is a promising and simple non-invasive biomarker for renal fibrosis.

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