Hydrodynamics-based liver transfection achieves gene silencing of CB1 using short hairpin RNA plasmid in cirrhotic rats

BACKGROUND: There is a correlation between the endocannabinoid system and hepatic fibrosis based on the activation of CB1 and CB2 receptors; where CB1 has profibrogenic effects. Gene therapy with a plasmid carrying a shRNA for CB1 delivered by hydrodynamic injection has the advantage of hepatic trop...

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Detalles Bibliográficos
Autores principales: Díaz-Rivera, Adriana, Meza-Ríos, Alejandra, Chagoya de Sánchez, Victoria, Velasco-Loyden, Gabriela, García-Benavides, Leonel, Jave-Suarez, Luis F., Monroy-Ramirez, Hugo Christian, Santos-García, Arturo, Armendáriz-Borunda, Juan, Sandoval-Rodríguez, Ana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018086/
https://www.ncbi.nlm.nih.gov/pubmed/32053633
http://dx.doi.org/10.1371/journal.pone.0228729

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018086/
https://www.ncbi.nlm.nih.gov/pubmed/32053633
http://dx.doi.org/10.1371/journal.pone.0228729

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