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Risk factors for community-onset urinary tract infections caused by extended-spectrum β-lactamase-producing Escherichia coli

BACKGROUND/AIM: Community-onset urinary tract infections (UTIs) caused by extended-spectrum β-lactamase (ESBL)-producing Escherichia coli have increased in many parts of the world. This study aimed to determine the prevalence and risk factors for community-onset UTI caused by ESBL-producing E. coli....

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Autores principales: TÜZÜN, Türkan, SAYIN KUTLU, Selda, KUTLU, Murat, KALELİ, Ilknur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Scientific and Technological Research Council of Turkey 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018203/
https://www.ncbi.nlm.nih.gov/pubmed/31385490
http://dx.doi.org/10.3906/sag-1902-24
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author TÜZÜN, Türkan
SAYIN KUTLU, Selda
KUTLU, Murat
KALELİ, Ilknur
author_facet TÜZÜN, Türkan
SAYIN KUTLU, Selda
KUTLU, Murat
KALELİ, Ilknur
author_sort TÜZÜN, Türkan
collection PubMed
description BACKGROUND/AIM: Community-onset urinary tract infections (UTIs) caused by extended-spectrum β-lactamase (ESBL)-producing Escherichia coli have increased in many parts of the world. This study aimed to determine the prevalence and risk factors for community-onset UTI caused by ESBL-producing E. coli. MATERIALS AND METHODS: This prospective cohort study was conducted between January 2012 and March 2014 in cases of community-onset UTI caused by E. coli. Patients with UTI due to ESBL-producing E. coli and patients with UTI due to non-ESBL-producing E. coli were compared to identify risk factors for ESBL-producing E. coli in the community. RESULTS: A total of 305 patients (116 males [46.4%]; mean age: 57.76 ± 18.06 years) were included in the study. Among these patients, 154 (50.5%) were infected with ESBL-producing E. coli. In multivariate analysis, the healthcare-associated UTI (odds ratio [OR]: 1.80; 95% confidence interval [CI]: 1.02–3.18; P = 0.041), upper urinary tract infection (OR: 3.05; 95% CI: 1.76–5.29; P < 0.0001), use of antibiotics in the preceding 6 months (OR: 2.28; 95% CI: 1.21–4.30; P = 0.011), and having two or more risk factors (OR: 4.03; 95% CI: 1.73–9.35; P = 0.001) were the significant factors associated with increased risk of community-onset UTIs due to ESBL-producing E. coli. CONCLUSION: The increasing prevalence ofESBL-producing E. coli makes it difficult to decide the empirical therapy in UTIs, especially in patients with two or more of the risk factors. A better understanding of the epidemiology and risk factors associated with community-onset UTIs due to ESBL-producing E. coli may have significant implications in decision-making for empirical antimicrobial treatment.
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spelling pubmed-70182032020-03-23 Risk factors for community-onset urinary tract infections caused by extended-spectrum β-lactamase-producing Escherichia coli TÜZÜN, Türkan SAYIN KUTLU, Selda KUTLU, Murat KALELİ, Ilknur Turk J Med Sci Article BACKGROUND/AIM: Community-onset urinary tract infections (UTIs) caused by extended-spectrum β-lactamase (ESBL)-producing Escherichia coli have increased in many parts of the world. This study aimed to determine the prevalence and risk factors for community-onset UTI caused by ESBL-producing E. coli. MATERIALS AND METHODS: This prospective cohort study was conducted between January 2012 and March 2014 in cases of community-onset UTI caused by E. coli. Patients with UTI due to ESBL-producing E. coli and patients with UTI due to non-ESBL-producing E. coli were compared to identify risk factors for ESBL-producing E. coli in the community. RESULTS: A total of 305 patients (116 males [46.4%]; mean age: 57.76 ± 18.06 years) were included in the study. Among these patients, 154 (50.5%) were infected with ESBL-producing E. coli. In multivariate analysis, the healthcare-associated UTI (odds ratio [OR]: 1.80; 95% confidence interval [CI]: 1.02–3.18; P = 0.041), upper urinary tract infection (OR: 3.05; 95% CI: 1.76–5.29; P < 0.0001), use of antibiotics in the preceding 6 months (OR: 2.28; 95% CI: 1.21–4.30; P = 0.011), and having two or more risk factors (OR: 4.03; 95% CI: 1.73–9.35; P = 0.001) were the significant factors associated with increased risk of community-onset UTIs due to ESBL-producing E. coli. CONCLUSION: The increasing prevalence ofESBL-producing E. coli makes it difficult to decide the empirical therapy in UTIs, especially in patients with two or more of the risk factors. A better understanding of the epidemiology and risk factors associated with community-onset UTIs due to ESBL-producing E. coli may have significant implications in decision-making for empirical antimicrobial treatment. The Scientific and Technological Research Council of Turkey 2019-08-08 /pmc/articles/PMC7018203/ /pubmed/31385490 http://dx.doi.org/10.3906/sag-1902-24 Text en Copyright © 2019 The Author(s) This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Article
TÜZÜN, Türkan
SAYIN KUTLU, Selda
KUTLU, Murat
KALELİ, Ilknur
Risk factors for community-onset urinary tract infections caused by extended-spectrum β-lactamase-producing Escherichia coli
title Risk factors for community-onset urinary tract infections caused by extended-spectrum β-lactamase-producing Escherichia coli
title_full Risk factors for community-onset urinary tract infections caused by extended-spectrum β-lactamase-producing Escherichia coli
title_fullStr Risk factors for community-onset urinary tract infections caused by extended-spectrum β-lactamase-producing Escherichia coli
title_full_unstemmed Risk factors for community-onset urinary tract infections caused by extended-spectrum β-lactamase-producing Escherichia coli
title_short Risk factors for community-onset urinary tract infections caused by extended-spectrum β-lactamase-producing Escherichia coli
title_sort risk factors for community-onset urinary tract infections caused by extended-spectrum β-lactamase-producing escherichia coli
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018203/
https://www.ncbi.nlm.nih.gov/pubmed/31385490
http://dx.doi.org/10.3906/sag-1902-24
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