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In vitro combination of tigecycline with other antibiotics in Stenotrophomonas maltophilia isolates
BACKGROUND/AIM: The aim of this study was to determine the usefulness of tigecycline in combination treatment of Stenotrophomonas maltophilia infections by evaluating the in vitro synergistic effects of tigecycline with various antibiotics using the E-test method. MATERIALS AND METHODS: Synergy test...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Scientific and Technological Research Council of Turkey
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018222/ https://www.ncbi.nlm.nih.gov/pubmed/30866602 http://dx.doi.org/10.3906/sag-1808-55 |
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author | KARAMANLIOĞLU, Dilek DİZBAY, Murat |
author_facet | KARAMANLIOĞLU, Dilek DİZBAY, Murat |
author_sort | KARAMANLIOĞLU, Dilek |
collection | PubMed |
description | BACKGROUND/AIM: The aim of this study was to determine the usefulness of tigecycline in combination treatment of Stenotrophomonas maltophilia infections by evaluating the in vitro synergistic effects of tigecycline with various antibiotics using the E-test method. MATERIALS AND METHODS: Synergy testing by E-test was performed with various antibiotic combinations in 10 S. maltophilia isolates identified as a cause of infection. The antibiotics used in the study included tigecycline (TGC), cefoperazone-sulbactam (CPS), ceftazidime (TZ), levofloxacin (LEV), and trimethoprim-sulfamethoxazole (cotrimoxazole) (TS). Four different combinations (TGC-CPS, TGC-TZ, TGC-LEV, TGC-TS) were studied with the E-test synergy method. RESULTS: S. maltophilia isolates were found to have the highest level of susceptibility to trimethoprim-sulfamethoxazole, tigecycline, and levofloxacin. The fractional inhibitory concentration (FIC) index was calculated as FIC = MICAB/MICA + MICBA/MICB. The FIC index values were calculated and classified as synergistic (FIC < 0.5), additive (FIC = 0.5–1), indifferent (FIC = 1–4), and antagonistic (FIC > 4). According to FIC index values, synergy was found with the highest rate with TGC-CPS and TGC-LEV combinations (20%). Antagonistic activity was not found in any combination. CONCLUSION: When trimethoprim-sulfamethoxazole cannot be used because of resistance or allergy, tigecycline alone or in combination may be included as an alternative option. Although in vitro results are promising, clinical data are required. |
format | Online Article Text |
id | pubmed-7018222 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | The Scientific and Technological Research Council of Turkey |
record_format | MEDLINE/PubMed |
spelling | pubmed-70182222020-03-23 In vitro combination of tigecycline with other antibiotics in Stenotrophomonas maltophilia isolates KARAMANLIOĞLU, Dilek DİZBAY, Murat Turk J Med Sci Article BACKGROUND/AIM: The aim of this study was to determine the usefulness of tigecycline in combination treatment of Stenotrophomonas maltophilia infections by evaluating the in vitro synergistic effects of tigecycline with various antibiotics using the E-test method. MATERIALS AND METHODS: Synergy testing by E-test was performed with various antibiotic combinations in 10 S. maltophilia isolates identified as a cause of infection. The antibiotics used in the study included tigecycline (TGC), cefoperazone-sulbactam (CPS), ceftazidime (TZ), levofloxacin (LEV), and trimethoprim-sulfamethoxazole (cotrimoxazole) (TS). Four different combinations (TGC-CPS, TGC-TZ, TGC-LEV, TGC-TS) were studied with the E-test synergy method. RESULTS: S. maltophilia isolates were found to have the highest level of susceptibility to trimethoprim-sulfamethoxazole, tigecycline, and levofloxacin. The fractional inhibitory concentration (FIC) index was calculated as FIC = MICAB/MICA + MICBA/MICB. The FIC index values were calculated and classified as synergistic (FIC < 0.5), additive (FIC = 0.5–1), indifferent (FIC = 1–4), and antagonistic (FIC > 4). According to FIC index values, synergy was found with the highest rate with TGC-CPS and TGC-LEV combinations (20%). Antagonistic activity was not found in any combination. CONCLUSION: When trimethoprim-sulfamethoxazole cannot be used because of resistance or allergy, tigecycline alone or in combination may be included as an alternative option. Although in vitro results are promising, clinical data are required. The Scientific and Technological Research Council of Turkey 2019-04-18 /pmc/articles/PMC7018222/ /pubmed/30866602 http://dx.doi.org/10.3906/sag-1808-55 Text en Copyright © 2019 The Author(s) This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Article KARAMANLIOĞLU, Dilek DİZBAY, Murat In vitro combination of tigecycline with other antibiotics in Stenotrophomonas maltophilia isolates |
title | In vitro combination of tigecycline with other antibiotics in Stenotrophomonas maltophilia isolates |
title_full | In vitro combination of tigecycline with other antibiotics in Stenotrophomonas maltophilia isolates |
title_fullStr | In vitro combination of tigecycline with other antibiotics in Stenotrophomonas maltophilia isolates |
title_full_unstemmed | In vitro combination of tigecycline with other antibiotics in Stenotrophomonas maltophilia isolates |
title_short | In vitro combination of tigecycline with other antibiotics in Stenotrophomonas maltophilia isolates |
title_sort | in vitro combination of tigecycline with other antibiotics in stenotrophomonas maltophilia isolates |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018222/ https://www.ncbi.nlm.nih.gov/pubmed/30866602 http://dx.doi.org/10.3906/sag-1808-55 |
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