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Alterations in serum levels of copper, zinc, and selenium among children with sickle cell anemia

BACKGROUND/AIM: Oxidative stress contributes to pathophysiological dysfunction in sickle cell anemia (SCA). Copper (Cu) is a prooxidant, whereas zinc (Zn) and selenium (Se) are antioxidant trace elements. This study investigates the serum levels of Cu, Zn, and Se among children with SCA. MATERIALS A...

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Autor principal: HASANATO, Rana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Scientific and Technological Research Council of Turkey 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018245/
https://www.ncbi.nlm.nih.gov/pubmed/31648429
http://dx.doi.org/10.3906/sag-1812-92
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author HASANATO, Rana
author_facet HASANATO, Rana
author_sort HASANATO, Rana
collection PubMed
description BACKGROUND/AIM: Oxidative stress contributes to pathophysiological dysfunction in sickle cell anemia (SCA). Copper (Cu) is a prooxidant, whereas zinc (Zn) and selenium (Se) are antioxidant trace elements. This study investigates the serum levels of Cu, Zn, and Se among children with SCA. MATERIALS AND METHODS: This cross-sectional study was performed at King Khalid University Hospital, Riyadh. Thirty-three children with SCA in steady state and 33 age- and sex-matched normal healthy children were included in the study. Cu, Zn, and Se levels were measured by inductively coupled plasma-mass spectrometry (ICP-MS) instrument. RESULTS: The median serum Cu levels among SCA patients (1.3 μg/mL) were higher than those of the controls (0.88 μg/mL; P < 0.0001). Zn (0.61 μg/mL) and Se (74 ng/mL) levels among SCA patients, however, were significantly lower than those of the controls (0.94 μg/mL; P < 0.0001) and (91.2 ng/mL; P < 0.0001), respectively. The Cu/Zn ratio among SCA patients (1.92) was higher than that of the controls (0.98). CONCLUSION: Decreased blood levels of antioxidant trace elements may contribute to the pathophysiology in SCA by promoting oxidative stress. The monitoring of trace element levels in SCA appears to be vital for decreasing morbidity associated with the disorder.
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spelling pubmed-70182452020-03-23 Alterations in serum levels of copper, zinc, and selenium among children with sickle cell anemia HASANATO, Rana Turk J Med Sci Article BACKGROUND/AIM: Oxidative stress contributes to pathophysiological dysfunction in sickle cell anemia (SCA). Copper (Cu) is a prooxidant, whereas zinc (Zn) and selenium (Se) are antioxidant trace elements. This study investigates the serum levels of Cu, Zn, and Se among children with SCA. MATERIALS AND METHODS: This cross-sectional study was performed at King Khalid University Hospital, Riyadh. Thirty-three children with SCA in steady state and 33 age- and sex-matched normal healthy children were included in the study. Cu, Zn, and Se levels were measured by inductively coupled plasma-mass spectrometry (ICP-MS) instrument. RESULTS: The median serum Cu levels among SCA patients (1.3 μg/mL) were higher than those of the controls (0.88 μg/mL; P < 0.0001). Zn (0.61 μg/mL) and Se (74 ng/mL) levels among SCA patients, however, were significantly lower than those of the controls (0.94 μg/mL; P < 0.0001) and (91.2 ng/mL; P < 0.0001), respectively. The Cu/Zn ratio among SCA patients (1.92) was higher than that of the controls (0.98). CONCLUSION: Decreased blood levels of antioxidant trace elements may contribute to the pathophysiology in SCA by promoting oxidative stress. The monitoring of trace element levels in SCA appears to be vital for decreasing morbidity associated with the disorder. The Scientific and Technological Research Council of Turkey 2019-10-24 /pmc/articles/PMC7018245/ /pubmed/31648429 http://dx.doi.org/10.3906/sag-1812-92 Text en Copyright © 2019 The Author(s) This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Article
HASANATO, Rana
Alterations in serum levels of copper, zinc, and selenium among children with sickle cell anemia
title Alterations in serum levels of copper, zinc, and selenium among children with sickle cell anemia
title_full Alterations in serum levels of copper, zinc, and selenium among children with sickle cell anemia
title_fullStr Alterations in serum levels of copper, zinc, and selenium among children with sickle cell anemia
title_full_unstemmed Alterations in serum levels of copper, zinc, and selenium among children with sickle cell anemia
title_short Alterations in serum levels of copper, zinc, and selenium among children with sickle cell anemia
title_sort alterations in serum levels of copper, zinc, and selenium among children with sickle cell anemia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018245/
https://www.ncbi.nlm.nih.gov/pubmed/31648429
http://dx.doi.org/10.3906/sag-1812-92
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