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Opposite changes in APP processing and human Aβ levels in rats carrying either a protective or a pathogenic APP mutation

Cleavage of APP by BACE1/β-secretase initiates the amyloidogenic cascade leading to Amyloid-β (Aβ) production. α-Secretase initiates the non-amyloidogenic pathway preventing Aβ production. Several APP mutations cause familial Alzheimer’s disease (AD), while the Icelandic APP mutation near the BACE1-...

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Detalles Bibliográficos
Autores principales:	Tambini, Marc D, Norris, Kelly A, D'Adamio, Luciano
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2020
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018507/ https://www.ncbi.nlm.nih.gov/pubmed/32022689 http://dx.doi.org/10.7554/eLife.52612

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