Both ADP-Ribosyl-Binding and Hydrolase Activities of the Alphavirus nsP3 Macrodomain Affect Neurovirulence in Mice

Macrodomain (MD), a highly conserved protein fold present in a subset of plus-strand RNA viruses, binds to and hydrolyzes ADP-ribose (ADPr) from ADP-ribosylated proteins. ADPr-binding by the alphavirus nonstructural protein 3 (nsP3) MD is necessary for the initiation of virus replication in neural c...

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Detalles Bibliográficos
Autores principales: Abraham, Rachy, McPherson, Robert L., Dasovich, Morgan, Badiee, Mohsen, Leung, Anthony K. L., Griffin, Diane E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018654/
https://www.ncbi.nlm.nih.gov/pubmed/32047134
http://dx.doi.org/10.1128/mBio.03253-19

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018654/
https://www.ncbi.nlm.nih.gov/pubmed/32047134
http://dx.doi.org/10.1128/mBio.03253-19

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