The Function of the HGF/c-Met Axis in Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide, leading to a large global cancer burden. Hepatocyte growth factor (HGF) and its high-affinity receptor, mesenchymal epithelial transition factor (c-Met), are closely related to the onset, progression, and metastasis of...

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Autores principales: Wang, Haiyu, Rao, Benchen, Lou, Jiamin, Li, Jianhao, Liu, Zhenguo, Li, Ang, Cui, Guangying, Ren, Zhigang, Yu, Zujiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018668/
https://www.ncbi.nlm.nih.gov/pubmed/32117981
http://dx.doi.org/10.3389/fcell.2020.00055
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author Wang, Haiyu
Rao, Benchen
Lou, Jiamin
Li, Jianhao
Liu, Zhenguo
Li, Ang
Cui, Guangying
Ren, Zhigang
Yu, Zujiang
author_facet Wang, Haiyu
Rao, Benchen
Lou, Jiamin
Li, Jianhao
Liu, Zhenguo
Li, Ang
Cui, Guangying
Ren, Zhigang
Yu, Zujiang
author_sort Wang, Haiyu
collection PubMed
description Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide, leading to a large global cancer burden. Hepatocyte growth factor (HGF) and its high-affinity receptor, mesenchymal epithelial transition factor (c-Met), are closely related to the onset, progression, and metastasis of multiple tumors. The HGF/c-Met axis is involved in cell proliferation, movement, differentiation, invasion, angiogenesis, and apoptosis by activating multiple downstream signaling pathways. In this review, we focus on the function of the HGF/c-Met axis in HCC. The HGF/c-Met axis promotes the onset, proliferation, invasion, and metastasis of HCC. Moreover, it can serve as a biomarker for diagnosis and prognosis, as well as a therapeutic target for HCC. In addition, it is closely related to drug resistance during HCC treatment.
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spelling pubmed-70186682020-02-28 The Function of the HGF/c-Met Axis in Hepatocellular Carcinoma Wang, Haiyu Rao, Benchen Lou, Jiamin Li, Jianhao Liu, Zhenguo Li, Ang Cui, Guangying Ren, Zhigang Yu, Zujiang Front Cell Dev Biol Cell and Developmental Biology Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide, leading to a large global cancer burden. Hepatocyte growth factor (HGF) and its high-affinity receptor, mesenchymal epithelial transition factor (c-Met), are closely related to the onset, progression, and metastasis of multiple tumors. The HGF/c-Met axis is involved in cell proliferation, movement, differentiation, invasion, angiogenesis, and apoptosis by activating multiple downstream signaling pathways. In this review, we focus on the function of the HGF/c-Met axis in HCC. The HGF/c-Met axis promotes the onset, proliferation, invasion, and metastasis of HCC. Moreover, it can serve as a biomarker for diagnosis and prognosis, as well as a therapeutic target for HCC. In addition, it is closely related to drug resistance during HCC treatment. Frontiers Media S.A. 2020-02-07 /pmc/articles/PMC7018668/ /pubmed/32117981 http://dx.doi.org/10.3389/fcell.2020.00055 Text en Copyright © 2020 Wang, Rao, Lou, Li, Liu, Li, Cui, Ren and Yu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Wang, Haiyu
Rao, Benchen
Lou, Jiamin
Li, Jianhao
Liu, Zhenguo
Li, Ang
Cui, Guangying
Ren, Zhigang
Yu, Zujiang
The Function of the HGF/c-Met Axis in Hepatocellular Carcinoma
title The Function of the HGF/c-Met Axis in Hepatocellular Carcinoma
title_full The Function of the HGF/c-Met Axis in Hepatocellular Carcinoma
title_fullStr The Function of the HGF/c-Met Axis in Hepatocellular Carcinoma
title_full_unstemmed The Function of the HGF/c-Met Axis in Hepatocellular Carcinoma
title_short The Function of the HGF/c-Met Axis in Hepatocellular Carcinoma
title_sort function of the hgf/c-met axis in hepatocellular carcinoma
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018668/
https://www.ncbi.nlm.nih.gov/pubmed/32117981
http://dx.doi.org/10.3389/fcell.2020.00055
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