Rejuvenating the blood and bone marrow to slow aging-associated cognitive decline and Alzheimer’s disease

Parabiosis, blood exchange and plasma transfer experiments have highlighted the rejuvenating properties of young blood. Our Communications Biology study demonstrated that young bone marrow transplantation attenuates cognitive decline in old mice, with preservation of hippocampal synapses and reduced...

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Autores principales: Kang, Seokjo, Moser, V. Alexandra, Svendsen, Clive N., Goodridge, Helen S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018752/
https://www.ncbi.nlm.nih.gov/pubmed/32054965
http://dx.doi.org/10.1038/s42003-020-0797-4
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author Kang, Seokjo
Moser, V. Alexandra
Svendsen, Clive N.
Goodridge, Helen S.
author_facet Kang, Seokjo
Moser, V. Alexandra
Svendsen, Clive N.
Goodridge, Helen S.
author_sort Kang, Seokjo
collection PubMed
description Parabiosis, blood exchange and plasma transfer experiments have highlighted the rejuvenating properties of young blood. Our Communications Biology study demonstrated that young bone marrow transplantation attenuates cognitive decline in old mice, with preservation of hippocampal synapses and reduced microglial reactivity. We now discuss subsequent studies that shed additional light on how blood impacts cognitive function, and potential clinical applications, including ongoing clinical trials with young plasma and experimental strategies targeting the hematopoietic system to slow or reverse cognitive decline.
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spelling pubmed-70187522020-03-03 Rejuvenating the blood and bone marrow to slow aging-associated cognitive decline and Alzheimer’s disease Kang, Seokjo Moser, V. Alexandra Svendsen, Clive N. Goodridge, Helen S. Commun Biol Comment Parabiosis, blood exchange and plasma transfer experiments have highlighted the rejuvenating properties of young blood. Our Communications Biology study demonstrated that young bone marrow transplantation attenuates cognitive decline in old mice, with preservation of hippocampal synapses and reduced microglial reactivity. We now discuss subsequent studies that shed additional light on how blood impacts cognitive function, and potential clinical applications, including ongoing clinical trials with young plasma and experimental strategies targeting the hematopoietic system to slow or reverse cognitive decline. Nature Publishing Group UK 2020-02-13 /pmc/articles/PMC7018752/ /pubmed/32054965 http://dx.doi.org/10.1038/s42003-020-0797-4 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Comment
Kang, Seokjo
Moser, V. Alexandra
Svendsen, Clive N.
Goodridge, Helen S.
Rejuvenating the blood and bone marrow to slow aging-associated cognitive decline and Alzheimer’s disease
title Rejuvenating the blood and bone marrow to slow aging-associated cognitive decline and Alzheimer’s disease
title_full Rejuvenating the blood and bone marrow to slow aging-associated cognitive decline and Alzheimer’s disease
title_fullStr Rejuvenating the blood and bone marrow to slow aging-associated cognitive decline and Alzheimer’s disease
title_full_unstemmed Rejuvenating the blood and bone marrow to slow aging-associated cognitive decline and Alzheimer’s disease
title_short Rejuvenating the blood and bone marrow to slow aging-associated cognitive decline and Alzheimer’s disease
title_sort rejuvenating the blood and bone marrow to slow aging-associated cognitive decline and alzheimer’s disease
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018752/
https://www.ncbi.nlm.nih.gov/pubmed/32054965
http://dx.doi.org/10.1038/s42003-020-0797-4
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