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Improved betulinic acid biosynthesis using synthetic yeast chromosome recombination and semi-automated rapid LC-MS screening

Synthetic biology, genome engineering and directed evolution offer innumerable tools to expedite engineering of strains for optimising biosynthetic pathways. One of the most radical is SCRaMbLE, a system of inducible in vivo deletion and rearrangement of synthetic yeast chromosomes, diversifying the...

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Detalles Bibliográficos
Autores principales:	Gowers, G.-O. F., Chee, S. M., Bell, D., Suckling, L., Kern, M., Tew, D., McClymont, D. W., Ellis, T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018806/ https://www.ncbi.nlm.nih.gov/pubmed/32054834 http://dx.doi.org/10.1038/s41467-020-14708-z

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