RAGE regulates oxytocin transport into the brain

Oxytocin, a nonapeptide hormone, has a key role in female reproductive functions as well as in social memory in the brain. In our recent Communications Biology article, we reported that oxytocin is transported from the peripheral blood into the brain by the receptor for advanced glycation end-produc...

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Autores principales: Yamamoto, Yasuhiko, Higashida, Haruhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018824/
https://www.ncbi.nlm.nih.gov/pubmed/32054984
http://dx.doi.org/10.1038/s42003-020-0799-2
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author Yamamoto, Yasuhiko
Higashida, Haruhiro
author_facet Yamamoto, Yasuhiko
Higashida, Haruhiro
author_sort Yamamoto, Yasuhiko
collection PubMed
description Oxytocin, a nonapeptide hormone, has a key role in female reproductive functions as well as in social memory in the brain. In our recent Communications Biology article, we reported that oxytocin is transported from the peripheral blood into the brain by the receptor for advanced glycation end-products (RAGE) in endothelial cells at the blood−brain barrier. Additionally, we found that oral oxytocin is absorbed by RAGE on intestinal epithelial cells at the blood−intestinal barrier. From a physiological perspective, we herein outline the continuing research regarding oxytocin and social behaviour.
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spelling pubmed-70188242020-03-03 RAGE regulates oxytocin transport into the brain Yamamoto, Yasuhiko Higashida, Haruhiro Commun Biol Comment Oxytocin, a nonapeptide hormone, has a key role in female reproductive functions as well as in social memory in the brain. In our recent Communications Biology article, we reported that oxytocin is transported from the peripheral blood into the brain by the receptor for advanced glycation end-products (RAGE) in endothelial cells at the blood−brain barrier. Additionally, we found that oral oxytocin is absorbed by RAGE on intestinal epithelial cells at the blood−intestinal barrier. From a physiological perspective, we herein outline the continuing research regarding oxytocin and social behaviour. Nature Publishing Group UK 2020-02-13 /pmc/articles/PMC7018824/ /pubmed/32054984 http://dx.doi.org/10.1038/s42003-020-0799-2 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Comment
Yamamoto, Yasuhiko
Higashida, Haruhiro
RAGE regulates oxytocin transport into the brain
title RAGE regulates oxytocin transport into the brain
title_full RAGE regulates oxytocin transport into the brain
title_fullStr RAGE regulates oxytocin transport into the brain
title_full_unstemmed RAGE regulates oxytocin transport into the brain
title_short RAGE regulates oxytocin transport into the brain
title_sort rage regulates oxytocin transport into the brain
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018824/
https://www.ncbi.nlm.nih.gov/pubmed/32054984
http://dx.doi.org/10.1038/s42003-020-0799-2
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