Cargando…
Paternal leakage of mitochondrial DNA and maternal inheritance of heteroplasmy in Drosophila hybrids
Mitochondrial DNA (mtDNA) is maternally transmitted in animals and therefore, individuals are expected to have a single mtDNA haplotype (homoplasmy). Yet, heteroplasmic individuals have been observed in a large number of animal species. Heteroplasmy may emerge as a result of somatic mtDNA mutations,...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018837/ https://www.ncbi.nlm.nih.gov/pubmed/32054873 http://dx.doi.org/10.1038/s41598-020-59194-x |
_version_ | 1783497405407166464 |
---|---|
author | Polovina, Eirini-Slavka Parakatselaki, Maria-Eleni Ladoukakis, Emmanuel D. |
author_facet | Polovina, Eirini-Slavka Parakatselaki, Maria-Eleni Ladoukakis, Emmanuel D. |
author_sort | Polovina, Eirini-Slavka |
collection | PubMed |
description | Mitochondrial DNA (mtDNA) is maternally transmitted in animals and therefore, individuals are expected to have a single mtDNA haplotype (homoplasmy). Yet, heteroplasmic individuals have been observed in a large number of animal species. Heteroplasmy may emerge as a result of somatic mtDNA mutations, paternal leakage during fertilization or be inherited from a heteroplasmic mother. Understanding the causes of heteroplasmy could shed light into the evolution of mtDNA inheritance. In this study we examined heteroplasmy in progeny from heterospecific crosses of Drosophila for two consecutive generations. We studied the generation of heteroplasmy from paternal leakage and the maternal transmission of heteroplasmy. Our data reveal non-random patterns in the emergence and transmission of heteroplasmy and suggest that heteroplasmy depends on the family of origin. |
format | Online Article Text |
id | pubmed-7018837 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-70188372020-02-21 Paternal leakage of mitochondrial DNA and maternal inheritance of heteroplasmy in Drosophila hybrids Polovina, Eirini-Slavka Parakatselaki, Maria-Eleni Ladoukakis, Emmanuel D. Sci Rep Article Mitochondrial DNA (mtDNA) is maternally transmitted in animals and therefore, individuals are expected to have a single mtDNA haplotype (homoplasmy). Yet, heteroplasmic individuals have been observed in a large number of animal species. Heteroplasmy may emerge as a result of somatic mtDNA mutations, paternal leakage during fertilization or be inherited from a heteroplasmic mother. Understanding the causes of heteroplasmy could shed light into the evolution of mtDNA inheritance. In this study we examined heteroplasmy in progeny from heterospecific crosses of Drosophila for two consecutive generations. We studied the generation of heteroplasmy from paternal leakage and the maternal transmission of heteroplasmy. Our data reveal non-random patterns in the emergence and transmission of heteroplasmy and suggest that heteroplasmy depends on the family of origin. Nature Publishing Group UK 2020-02-13 /pmc/articles/PMC7018837/ /pubmed/32054873 http://dx.doi.org/10.1038/s41598-020-59194-x Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Polovina, Eirini-Slavka Parakatselaki, Maria-Eleni Ladoukakis, Emmanuel D. Paternal leakage of mitochondrial DNA and maternal inheritance of heteroplasmy in Drosophila hybrids |
title | Paternal leakage of mitochondrial DNA and maternal inheritance of heteroplasmy in Drosophila hybrids |
title_full | Paternal leakage of mitochondrial DNA and maternal inheritance of heteroplasmy in Drosophila hybrids |
title_fullStr | Paternal leakage of mitochondrial DNA and maternal inheritance of heteroplasmy in Drosophila hybrids |
title_full_unstemmed | Paternal leakage of mitochondrial DNA and maternal inheritance of heteroplasmy in Drosophila hybrids |
title_short | Paternal leakage of mitochondrial DNA and maternal inheritance of heteroplasmy in Drosophila hybrids |
title_sort | paternal leakage of mitochondrial dna and maternal inheritance of heteroplasmy in drosophila hybrids |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018837/ https://www.ncbi.nlm.nih.gov/pubmed/32054873 http://dx.doi.org/10.1038/s41598-020-59194-x |
work_keys_str_mv | AT polovinaeirinislavka paternalleakageofmitochondrialdnaandmaternalinheritanceofheteroplasmyindrosophilahybrids AT parakatselakimariaeleni paternalleakageofmitochondrialdnaandmaternalinheritanceofheteroplasmyindrosophilahybrids AT ladoukakisemmanueld paternalleakageofmitochondrialdnaandmaternalinheritanceofheteroplasmyindrosophilahybrids |