Cargando…

Paternal leakage of mitochondrial DNA and maternal inheritance of heteroplasmy in Drosophila hybrids

Mitochondrial DNA (mtDNA) is maternally transmitted in animals and therefore, individuals are expected to have a single mtDNA haplotype (homoplasmy). Yet, heteroplasmic individuals have been observed in a large number of animal species. Heteroplasmy may emerge as a result of somatic mtDNA mutations,...

Descripción completa

Detalles Bibliográficos
Autores principales: Polovina, Eirini-Slavka, Parakatselaki, Maria-Eleni, Ladoukakis, Emmanuel D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018837/
https://www.ncbi.nlm.nih.gov/pubmed/32054873
http://dx.doi.org/10.1038/s41598-020-59194-x
_version_ 1783497405407166464
author Polovina, Eirini-Slavka
Parakatselaki, Maria-Eleni
Ladoukakis, Emmanuel D.
author_facet Polovina, Eirini-Slavka
Parakatselaki, Maria-Eleni
Ladoukakis, Emmanuel D.
author_sort Polovina, Eirini-Slavka
collection PubMed
description Mitochondrial DNA (mtDNA) is maternally transmitted in animals and therefore, individuals are expected to have a single mtDNA haplotype (homoplasmy). Yet, heteroplasmic individuals have been observed in a large number of animal species. Heteroplasmy may emerge as a result of somatic mtDNA mutations, paternal leakage during fertilization or be inherited from a heteroplasmic mother. Understanding the causes of heteroplasmy could shed light into the evolution of mtDNA inheritance. In this study we examined heteroplasmy in progeny from heterospecific crosses of Drosophila for two consecutive generations. We studied the generation of heteroplasmy from paternal leakage and the maternal transmission of heteroplasmy. Our data reveal non-random patterns in the emergence and transmission of heteroplasmy and suggest that heteroplasmy depends on the family of origin.
format Online
Article
Text
id pubmed-7018837
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-70188372020-02-21 Paternal leakage of mitochondrial DNA and maternal inheritance of heteroplasmy in Drosophila hybrids Polovina, Eirini-Slavka Parakatselaki, Maria-Eleni Ladoukakis, Emmanuel D. Sci Rep Article Mitochondrial DNA (mtDNA) is maternally transmitted in animals and therefore, individuals are expected to have a single mtDNA haplotype (homoplasmy). Yet, heteroplasmic individuals have been observed in a large number of animal species. Heteroplasmy may emerge as a result of somatic mtDNA mutations, paternal leakage during fertilization or be inherited from a heteroplasmic mother. Understanding the causes of heteroplasmy could shed light into the evolution of mtDNA inheritance. In this study we examined heteroplasmy in progeny from heterospecific crosses of Drosophila for two consecutive generations. We studied the generation of heteroplasmy from paternal leakage and the maternal transmission of heteroplasmy. Our data reveal non-random patterns in the emergence and transmission of heteroplasmy and suggest that heteroplasmy depends on the family of origin. Nature Publishing Group UK 2020-02-13 /pmc/articles/PMC7018837/ /pubmed/32054873 http://dx.doi.org/10.1038/s41598-020-59194-x Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Polovina, Eirini-Slavka
Parakatselaki, Maria-Eleni
Ladoukakis, Emmanuel D.
Paternal leakage of mitochondrial DNA and maternal inheritance of heteroplasmy in Drosophila hybrids
title Paternal leakage of mitochondrial DNA and maternal inheritance of heteroplasmy in Drosophila hybrids
title_full Paternal leakage of mitochondrial DNA and maternal inheritance of heteroplasmy in Drosophila hybrids
title_fullStr Paternal leakage of mitochondrial DNA and maternal inheritance of heteroplasmy in Drosophila hybrids
title_full_unstemmed Paternal leakage of mitochondrial DNA and maternal inheritance of heteroplasmy in Drosophila hybrids
title_short Paternal leakage of mitochondrial DNA and maternal inheritance of heteroplasmy in Drosophila hybrids
title_sort paternal leakage of mitochondrial dna and maternal inheritance of heteroplasmy in drosophila hybrids
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018837/
https://www.ncbi.nlm.nih.gov/pubmed/32054873
http://dx.doi.org/10.1038/s41598-020-59194-x
work_keys_str_mv AT polovinaeirinislavka paternalleakageofmitochondrialdnaandmaternalinheritanceofheteroplasmyindrosophilahybrids
AT parakatselakimariaeleni paternalleakageofmitochondrialdnaandmaternalinheritanceofheteroplasmyindrosophilahybrids
AT ladoukakisemmanueld paternalleakageofmitochondrialdnaandmaternalinheritanceofheteroplasmyindrosophilahybrids