Deletion of a conserved Gata2 enhancer impairs haemogenic endothelium programming and adult Zebrafish haematopoiesis

Gata2 is a key transcription factor required to generate Haematopoietic Stem and Progenitor Cells (HSPCs) from haemogenic endothelium (HE); misexpression of Gata2 leads to haematopoietic disorders. Here we deleted a conserved enhancer (i4 enhancer) driving pan-endothelial expression of the zebrafish...

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Detalles Bibliográficos
Autores principales: Dobrzycki, Tomasz, Mahony, Christopher B., Krecsmarik, Monika, Koyunlar, Cansu, Rispoli, Rossella, Peulen-Zink, Joke, Gussinklo, Kirsten, Fedlaoui, Bakhta, de Pater, Emma, Patient, Roger, Monteiro, Rui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018942/
https://www.ncbi.nlm.nih.gov/pubmed/32054973
http://dx.doi.org/10.1038/s42003-020-0798-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018942/
https://www.ncbi.nlm.nih.gov/pubmed/32054973
http://dx.doi.org/10.1038/s42003-020-0798-3

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