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Inhibition of cyclooxygenase-1 by nonsteroidal anti-inflammatory drugs demethylates MeR2 enhancer and promotes Mbnl1 transcription in myogenic cells

Muscleblind-like 1 (MBNL1) is a ubiquitously expressed RNA-binding protein, which is highly expressed in skeletal muscle. Abnormally expanded CUG-repeats in the DMPK gene cause myotonic dystrophy type 1 (DM1) by sequestration of MBNL1 to nuclear RNA foci and by upregulation of another RNA-binding pr...

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Detalles Bibliográficos
Autores principales:	Huang, Kun, Masuda, Akio, Chen, Guiying, Bushra, Samira, Kamon, Masayoshi, Araki, Toshiyuki, Kinoshita, Masanobu, Ohkawara, Bisei, Ito, Mikako, Ohno, Kinji
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018979/ https://www.ncbi.nlm.nih.gov/pubmed/32054946 http://dx.doi.org/10.1038/s41598-020-59517-y

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