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A tuberculosis outbreak in a psychiatric hospital: Kanagawa, Japan, 2012

In January 2012, an inpatient in a ward of a psychiatric hospital with nearly 300 beds in Kanagawa, Japan, was diagnosed with sputum smear-positive pulmonary tuberculosis (TB). Here we characterise the TB outbreak cases and identify the population at risk. TB was diagnosed when a person tested bacte...

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Autores principales: Tasaka, M., Koeda, E., Takahashi, C., Ota, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019127/
https://www.ncbi.nlm.nih.gov/pubmed/31933448
http://dx.doi.org/10.1017/S0950268819002206
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author Tasaka, M.
Koeda, E.
Takahashi, C.
Ota, M.
author_facet Tasaka, M.
Koeda, E.
Takahashi, C.
Ota, M.
author_sort Tasaka, M.
collection PubMed
description In January 2012, an inpatient in a ward of a psychiatric hospital with nearly 300 beds in Kanagawa, Japan, was diagnosed with sputum smear-positive pulmonary tuberculosis (TB). Here we characterise the TB outbreak cases and identify the population at risk. TB was diagnosed when a person tested bacteriologically positive for TB or was determined to have TB by a physician. A latent TB infection (LTBI) case was defined as a person tested positive by interferon-gamma release assay (IGRA). A total of 125 contacts were screened via IGRA and chest X-ray. In all, 15 TB and 15 LTBI cases were found by the end of October 2012, and thereafter no additional TB case was found. Of the 15 TB cases, eight were culture-positive and all the isolates had identical variable number tandem repeat patterns. Twenty-four of the 56 (42.9%, 95% confidence interval (CI) 29.7–56.8) inpatients in the ward had either TB or LTBI with a relative risk of 8.6 (95% CI 1.2–59.3), compared to the staff members who did not work full-time in the ward (one of 20 (5.0%, 95% CI 0.0–24.9)). We recommend that psychiatric hospitals conduct periodic screening of staff members and inpatients for TB to prevent nosocomial TB outbreaks.
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spelling pubmed-70191272020-02-27 A tuberculosis outbreak in a psychiatric hospital: Kanagawa, Japan, 2012 Tasaka, M. Koeda, E. Takahashi, C. Ota, M. Epidemiol Infect Original Paper In January 2012, an inpatient in a ward of a psychiatric hospital with nearly 300 beds in Kanagawa, Japan, was diagnosed with sputum smear-positive pulmonary tuberculosis (TB). Here we characterise the TB outbreak cases and identify the population at risk. TB was diagnosed when a person tested bacteriologically positive for TB or was determined to have TB by a physician. A latent TB infection (LTBI) case was defined as a person tested positive by interferon-gamma release assay (IGRA). A total of 125 contacts were screened via IGRA and chest X-ray. In all, 15 TB and 15 LTBI cases were found by the end of October 2012, and thereafter no additional TB case was found. Of the 15 TB cases, eight were culture-positive and all the isolates had identical variable number tandem repeat patterns. Twenty-four of the 56 (42.9%, 95% confidence interval (CI) 29.7–56.8) inpatients in the ward had either TB or LTBI with a relative risk of 8.6 (95% CI 1.2–59.3), compared to the staff members who did not work full-time in the ward (one of 20 (5.0%, 95% CI 0.0–24.9)). We recommend that psychiatric hospitals conduct periodic screening of staff members and inpatients for TB to prevent nosocomial TB outbreaks. Cambridge University Press 2020-01-14 /pmc/articles/PMC7019127/ /pubmed/31933448 http://dx.doi.org/10.1017/S0950268819002206 Text en © The Authors and Japan Anti-Tuberculosis Association 2020 http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Paper
Tasaka, M.
Koeda, E.
Takahashi, C.
Ota, M.
A tuberculosis outbreak in a psychiatric hospital: Kanagawa, Japan, 2012
title A tuberculosis outbreak in a psychiatric hospital: Kanagawa, Japan, 2012
title_full A tuberculosis outbreak in a psychiatric hospital: Kanagawa, Japan, 2012
title_fullStr A tuberculosis outbreak in a psychiatric hospital: Kanagawa, Japan, 2012
title_full_unstemmed A tuberculosis outbreak in a psychiatric hospital: Kanagawa, Japan, 2012
title_short A tuberculosis outbreak in a psychiatric hospital: Kanagawa, Japan, 2012
title_sort tuberculosis outbreak in a psychiatric hospital: kanagawa, japan, 2012
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019127/
https://www.ncbi.nlm.nih.gov/pubmed/31933448
http://dx.doi.org/10.1017/S0950268819002206
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