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A tuberculosis outbreak in a psychiatric hospital: Kanagawa, Japan, 2012
In January 2012, an inpatient in a ward of a psychiatric hospital with nearly 300 beds in Kanagawa, Japan, was diagnosed with sputum smear-positive pulmonary tuberculosis (TB). Here we characterise the TB outbreak cases and identify the population at risk. TB was diagnosed when a person tested bacte...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cambridge University Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019127/ https://www.ncbi.nlm.nih.gov/pubmed/31933448 http://dx.doi.org/10.1017/S0950268819002206 |
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author | Tasaka, M. Koeda, E. Takahashi, C. Ota, M. |
author_facet | Tasaka, M. Koeda, E. Takahashi, C. Ota, M. |
author_sort | Tasaka, M. |
collection | PubMed |
description | In January 2012, an inpatient in a ward of a psychiatric hospital with nearly 300 beds in Kanagawa, Japan, was diagnosed with sputum smear-positive pulmonary tuberculosis (TB). Here we characterise the TB outbreak cases and identify the population at risk. TB was diagnosed when a person tested bacteriologically positive for TB or was determined to have TB by a physician. A latent TB infection (LTBI) case was defined as a person tested positive by interferon-gamma release assay (IGRA). A total of 125 contacts were screened via IGRA and chest X-ray. In all, 15 TB and 15 LTBI cases were found by the end of October 2012, and thereafter no additional TB case was found. Of the 15 TB cases, eight were culture-positive and all the isolates had identical variable number tandem repeat patterns. Twenty-four of the 56 (42.9%, 95% confidence interval (CI) 29.7–56.8) inpatients in the ward had either TB or LTBI with a relative risk of 8.6 (95% CI 1.2–59.3), compared to the staff members who did not work full-time in the ward (one of 20 (5.0%, 95% CI 0.0–24.9)). We recommend that psychiatric hospitals conduct periodic screening of staff members and inpatients for TB to prevent nosocomial TB outbreaks. |
format | Online Article Text |
id | pubmed-7019127 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Cambridge University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-70191272020-02-27 A tuberculosis outbreak in a psychiatric hospital: Kanagawa, Japan, 2012 Tasaka, M. Koeda, E. Takahashi, C. Ota, M. Epidemiol Infect Original Paper In January 2012, an inpatient in a ward of a psychiatric hospital with nearly 300 beds in Kanagawa, Japan, was diagnosed with sputum smear-positive pulmonary tuberculosis (TB). Here we characterise the TB outbreak cases and identify the population at risk. TB was diagnosed when a person tested bacteriologically positive for TB or was determined to have TB by a physician. A latent TB infection (LTBI) case was defined as a person tested positive by interferon-gamma release assay (IGRA). A total of 125 contacts were screened via IGRA and chest X-ray. In all, 15 TB and 15 LTBI cases were found by the end of October 2012, and thereafter no additional TB case was found. Of the 15 TB cases, eight were culture-positive and all the isolates had identical variable number tandem repeat patterns. Twenty-four of the 56 (42.9%, 95% confidence interval (CI) 29.7–56.8) inpatients in the ward had either TB or LTBI with a relative risk of 8.6 (95% CI 1.2–59.3), compared to the staff members who did not work full-time in the ward (one of 20 (5.0%, 95% CI 0.0–24.9)). We recommend that psychiatric hospitals conduct periodic screening of staff members and inpatients for TB to prevent nosocomial TB outbreaks. Cambridge University Press 2020-01-14 /pmc/articles/PMC7019127/ /pubmed/31933448 http://dx.doi.org/10.1017/S0950268819002206 Text en © The Authors and Japan Anti-Tuberculosis Association 2020 http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Paper Tasaka, M. Koeda, E. Takahashi, C. Ota, M. A tuberculosis outbreak in a psychiatric hospital: Kanagawa, Japan, 2012 |
title | A tuberculosis outbreak in a psychiatric hospital: Kanagawa, Japan, 2012 |
title_full | A tuberculosis outbreak in a psychiatric hospital: Kanagawa, Japan, 2012 |
title_fullStr | A tuberculosis outbreak in a psychiatric hospital: Kanagawa, Japan, 2012 |
title_full_unstemmed | A tuberculosis outbreak in a psychiatric hospital: Kanagawa, Japan, 2012 |
title_short | A tuberculosis outbreak in a psychiatric hospital: Kanagawa, Japan, 2012 |
title_sort | tuberculosis outbreak in a psychiatric hospital: kanagawa, japan, 2012 |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019127/ https://www.ncbi.nlm.nih.gov/pubmed/31933448 http://dx.doi.org/10.1017/S0950268819002206 |
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