Ranitidine and finasteride inhibit the synthesis and release of trimethylamine N-oxide and mitigates its cardiovascular and renal damage through modulating gut microbiota

Trimethylamine N-oxide (TMAO) leads to the development of cardiovascular and chronic kidney diseases, but there are currently no potent drugs that inhibit the production or toxicity of TMAO. In this study, high-fat diet-fed ApoE-/- mice were treated with finasteride, ranitidine, and andrioe. Subsequ...

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Detalles Bibliográficos
Autores principales: Liu, Junfeng, Lai, Lingyun, Lin, Jiajia, Zheng, Jiajia, Nie, Xiaoli, Zhu, Xiaoye, Xue, Jun, Liu, Te
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019130/
https://www.ncbi.nlm.nih.gov/pubmed/32071549
http://dx.doi.org/10.7150/ijbs.40934

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