Multiple Roles of sFRP2 in Cardiac Development and Cardiovascular Disease

The Wnt signaling pathway plays important roles in organ development and disease processes. Secreted frizzled-related protein 2 (sFRP2), a vital molecule of Wnt signaling, can regulate cardiac development and cardiovascular disease. Recent studies have suggested that sFRP2 is not only an antagonist...

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Detalles Bibliográficos
Autores principales: Wu, Yu, Liu, Xinyue, Zheng, Haoxiao, Zhu, Hailan, Mai, Weiyi, Huang, Xiaohui, Huang, Yuli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019133/
https://www.ncbi.nlm.nih.gov/pubmed/32071544
http://dx.doi.org/10.7150/ijbs.40923
Descripción
Sumario:The Wnt signaling pathway plays important roles in organ development and disease processes. Secreted frizzled-related protein 2 (sFRP2), a vital molecule of Wnt signaling, can regulate cardiac development and cardiovascular disease. Recent studies have suggested that sFRP2 is not only an antagonist of the canonical Wnt signaling pathway, but also has a more complex relationship in myocardial fibrosis, angiogenesis, cardiac hypertrophy and cardiac regeneration. Here, we review the role of sFRP2 and Wnt signaling in cardiac development and cardiovascular disease.

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