Multiple Roles of sFRP2 in Cardiac Development and Cardiovascular Disease

The Wnt signaling pathway plays important roles in organ development and disease processes. Secreted frizzled-related protein 2 (sFRP2), a vital molecule of Wnt signaling, can regulate cardiac development and cardiovascular disease. Recent studies have suggested that sFRP2 is not only an antagonist...

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Detalles Bibliográficos
Autores principales: Wu, Yu, Liu, Xinyue, Zheng, Haoxiao, Zhu, Hailan, Mai, Weiyi, Huang, Xiaohui, Huang, Yuli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019133/
https://www.ncbi.nlm.nih.gov/pubmed/32071544
http://dx.doi.org/10.7150/ijbs.40923
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author Wu, Yu
Liu, Xinyue
Zheng, Haoxiao
Zhu, Hailan
Mai, Weiyi
Huang, Xiaohui
Huang, Yuli
author_facet Wu, Yu
Liu, Xinyue
Zheng, Haoxiao
Zhu, Hailan
Mai, Weiyi
Huang, Xiaohui
Huang, Yuli
author_sort Wu, Yu
collection PubMed
description The Wnt signaling pathway plays important roles in organ development and disease processes. Secreted frizzled-related protein 2 (sFRP2), a vital molecule of Wnt signaling, can regulate cardiac development and cardiovascular disease. Recent studies have suggested that sFRP2 is not only an antagonist of the canonical Wnt signaling pathway, but also has a more complex relationship in myocardial fibrosis, angiogenesis, cardiac hypertrophy and cardiac regeneration. Here, we review the role of sFRP2 and Wnt signaling in cardiac development and cardiovascular disease.
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spelling pubmed-70191332020-02-18 Multiple Roles of sFRP2 in Cardiac Development and Cardiovascular Disease Wu, Yu Liu, Xinyue Zheng, Haoxiao Zhu, Hailan Mai, Weiyi Huang, Xiaohui Huang, Yuli Int J Biol Sci Review The Wnt signaling pathway plays important roles in organ development and disease processes. Secreted frizzled-related protein 2 (sFRP2), a vital molecule of Wnt signaling, can regulate cardiac development and cardiovascular disease. Recent studies have suggested that sFRP2 is not only an antagonist of the canonical Wnt signaling pathway, but also has a more complex relationship in myocardial fibrosis, angiogenesis, cardiac hypertrophy and cardiac regeneration. Here, we review the role of sFRP2 and Wnt signaling in cardiac development and cardiovascular disease. Ivyspring International Publisher 2020-01-14 /pmc/articles/PMC7019133/ /pubmed/32071544 http://dx.doi.org/10.7150/ijbs.40923 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Review
Wu, Yu
Liu, Xinyue
Zheng, Haoxiao
Zhu, Hailan
Mai, Weiyi
Huang, Xiaohui
Huang, Yuli
Multiple Roles of sFRP2 in Cardiac Development and Cardiovascular Disease
title Multiple Roles of sFRP2 in Cardiac Development and Cardiovascular Disease
title_full Multiple Roles of sFRP2 in Cardiac Development and Cardiovascular Disease
title_fullStr Multiple Roles of sFRP2 in Cardiac Development and Cardiovascular Disease
title_full_unstemmed Multiple Roles of sFRP2 in Cardiac Development and Cardiovascular Disease
title_short Multiple Roles of sFRP2 in Cardiac Development and Cardiovascular Disease
title_sort multiple roles of sfrp2 in cardiac development and cardiovascular disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019133/
https://www.ncbi.nlm.nih.gov/pubmed/32071544
http://dx.doi.org/10.7150/ijbs.40923
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