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Improvement of cognitive and motor performance with mitotherapy in aged mice

Changes in mitochondrial structure and function are mostly responsible for aging and age-related features. Whether healthy mitochondria could prevent aging is, however, unclear. Here we intravenously injected the mitochondria isolated from young mice into aged mice and investigated the mitotherapy o...

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Autores principales: Zhao, Zizhen, Yu, Zhenyao, Hou, Yixue, Zhang, Le, Fu, Ailing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019143/
https://www.ncbi.nlm.nih.gov/pubmed/32071554
http://dx.doi.org/10.7150/ijbs.40886
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author Zhao, Zizhen
Yu, Zhenyao
Hou, Yixue
Zhang, Le
Fu, Ailing
author_facet Zhao, Zizhen
Yu, Zhenyao
Hou, Yixue
Zhang, Le
Fu, Ailing
author_sort Zhao, Zizhen
collection PubMed
description Changes in mitochondrial structure and function are mostly responsible for aging and age-related features. Whether healthy mitochondria could prevent aging is, however, unclear. Here we intravenously injected the mitochondria isolated from young mice into aged mice and investigated the mitotherapy on biochemistry metabolism and animal behaviors. The results showed that heterozygous mitochondrial DNA (mtDNA) of both aged and young mouse coexisted in tissues of aged mice after mitochondrial administration, and meanwhile, ATP content in tissues increased while reactive oxygen species (ROS) level reduced. Besides, the mitotherapy significantly improved cognitive and motor performance of aged mice. Our study, at the first report in aged animals, not only provides a useful approach to study mitochondrial function associated with aging, but also a new insight into anti-aging through mitotherapy.
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spelling pubmed-70191432020-02-18 Improvement of cognitive and motor performance with mitotherapy in aged mice Zhao, Zizhen Yu, Zhenyao Hou, Yixue Zhang, Le Fu, Ailing Int J Biol Sci Research Paper Changes in mitochondrial structure and function are mostly responsible for aging and age-related features. Whether healthy mitochondria could prevent aging is, however, unclear. Here we intravenously injected the mitochondria isolated from young mice into aged mice and investigated the mitotherapy on biochemistry metabolism and animal behaviors. The results showed that heterozygous mitochondrial DNA (mtDNA) of both aged and young mouse coexisted in tissues of aged mice after mitochondrial administration, and meanwhile, ATP content in tissues increased while reactive oxygen species (ROS) level reduced. Besides, the mitotherapy significantly improved cognitive and motor performance of aged mice. Our study, at the first report in aged animals, not only provides a useful approach to study mitochondrial function associated with aging, but also a new insight into anti-aging through mitotherapy. Ivyspring International Publisher 2020-01-16 /pmc/articles/PMC7019143/ /pubmed/32071554 http://dx.doi.org/10.7150/ijbs.40886 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Zhao, Zizhen
Yu, Zhenyao
Hou, Yixue
Zhang, Le
Fu, Ailing
Improvement of cognitive and motor performance with mitotherapy in aged mice
title Improvement of cognitive and motor performance with mitotherapy in aged mice
title_full Improvement of cognitive and motor performance with mitotherapy in aged mice
title_fullStr Improvement of cognitive and motor performance with mitotherapy in aged mice
title_full_unstemmed Improvement of cognitive and motor performance with mitotherapy in aged mice
title_short Improvement of cognitive and motor performance with mitotherapy in aged mice
title_sort improvement of cognitive and motor performance with mitotherapy in aged mice
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019143/
https://www.ncbi.nlm.nih.gov/pubmed/32071554
http://dx.doi.org/10.7150/ijbs.40886
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