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Improvement of cognitive and motor performance with mitotherapy in aged mice
Changes in mitochondrial structure and function are mostly responsible for aging and age-related features. Whether healthy mitochondria could prevent aging is, however, unclear. Here we intravenously injected the mitochondria isolated from young mice into aged mice and investigated the mitotherapy o...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019143/ https://www.ncbi.nlm.nih.gov/pubmed/32071554 http://dx.doi.org/10.7150/ijbs.40886 |
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author | Zhao, Zizhen Yu, Zhenyao Hou, Yixue Zhang, Le Fu, Ailing |
author_facet | Zhao, Zizhen Yu, Zhenyao Hou, Yixue Zhang, Le Fu, Ailing |
author_sort | Zhao, Zizhen |
collection | PubMed |
description | Changes in mitochondrial structure and function are mostly responsible for aging and age-related features. Whether healthy mitochondria could prevent aging is, however, unclear. Here we intravenously injected the mitochondria isolated from young mice into aged mice and investigated the mitotherapy on biochemistry metabolism and animal behaviors. The results showed that heterozygous mitochondrial DNA (mtDNA) of both aged and young mouse coexisted in tissues of aged mice after mitochondrial administration, and meanwhile, ATP content in tissues increased while reactive oxygen species (ROS) level reduced. Besides, the mitotherapy significantly improved cognitive and motor performance of aged mice. Our study, at the first report in aged animals, not only provides a useful approach to study mitochondrial function associated with aging, but also a new insight into anti-aging through mitotherapy. |
format | Online Article Text |
id | pubmed-7019143 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-70191432020-02-18 Improvement of cognitive and motor performance with mitotherapy in aged mice Zhao, Zizhen Yu, Zhenyao Hou, Yixue Zhang, Le Fu, Ailing Int J Biol Sci Research Paper Changes in mitochondrial structure and function are mostly responsible for aging and age-related features. Whether healthy mitochondria could prevent aging is, however, unclear. Here we intravenously injected the mitochondria isolated from young mice into aged mice and investigated the mitotherapy on biochemistry metabolism and animal behaviors. The results showed that heterozygous mitochondrial DNA (mtDNA) of both aged and young mouse coexisted in tissues of aged mice after mitochondrial administration, and meanwhile, ATP content in tissues increased while reactive oxygen species (ROS) level reduced. Besides, the mitotherapy significantly improved cognitive and motor performance of aged mice. Our study, at the first report in aged animals, not only provides a useful approach to study mitochondrial function associated with aging, but also a new insight into anti-aging through mitotherapy. Ivyspring International Publisher 2020-01-16 /pmc/articles/PMC7019143/ /pubmed/32071554 http://dx.doi.org/10.7150/ijbs.40886 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
spellingShingle | Research Paper Zhao, Zizhen Yu, Zhenyao Hou, Yixue Zhang, Le Fu, Ailing Improvement of cognitive and motor performance with mitotherapy in aged mice |
title | Improvement of cognitive and motor performance with mitotherapy in aged mice |
title_full | Improvement of cognitive and motor performance with mitotherapy in aged mice |
title_fullStr | Improvement of cognitive and motor performance with mitotherapy in aged mice |
title_full_unstemmed | Improvement of cognitive and motor performance with mitotherapy in aged mice |
title_short | Improvement of cognitive and motor performance with mitotherapy in aged mice |
title_sort | improvement of cognitive and motor performance with mitotherapy in aged mice |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019143/ https://www.ncbi.nlm.nih.gov/pubmed/32071554 http://dx.doi.org/10.7150/ijbs.40886 |
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