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Gap-enhanced Raman tags: fabrication, optical properties, and theranostic applications

Gap-enhanced Raman tags (GERTs) are emerging probes of surface-enhanced Raman scattering (SERS) spectroscopy that have found promising analytical, bioimaging, and theranostic applications. Because of their internal location, Raman reporter molecules are protected from unwanted external environments...

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Detalles Bibliográficos
Autores principales: Khlebtsov, Nikolai G., Lin, Li, Khlebtsov, Boris N., Ye, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019156/
https://www.ncbi.nlm.nih.gov/pubmed/32089735
http://dx.doi.org/10.7150/thno.39968
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author Khlebtsov, Nikolai G.
Lin, Li
Khlebtsov, Boris N.
Ye, Jian
author_facet Khlebtsov, Nikolai G.
Lin, Li
Khlebtsov, Boris N.
Ye, Jian
author_sort Khlebtsov, Nikolai G.
collection PubMed
description Gap-enhanced Raman tags (GERTs) are emerging probes of surface-enhanced Raman scattering (SERS) spectroscopy that have found promising analytical, bioimaging, and theranostic applications. Because of their internal location, Raman reporter molecules are protected from unwanted external environments and particle aggregation and demonstrate superior SERS responses owing to the strongly enhanced electromagnetic fields in the gaps between metal core-shell structures. In this review, we discuss recent progress in the synthesis, simulation, and experimental studies of the optical properties and biomedical applications of novel spherically symmetrical and anisotropic GERTs fabricated with common plasmonic metals—gold (Au) and silver (Ag). Our discussion is focused on the design and synthetic strategies that ensure the optimal parameters and highest enhancement factors of GERTs for sensing and theranostics. In particular, we consider various core-shell structures with build-in nanogaps to explain why they would benefit the plasmonic GERTs as a superior SERS tag and how this would help future research in clinical analytics and therapeutics.
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spelling pubmed-70191562020-02-23 Gap-enhanced Raman tags: fabrication, optical properties, and theranostic applications Khlebtsov, Nikolai G. Lin, Li Khlebtsov, Boris N. Ye, Jian Theranostics Review Gap-enhanced Raman tags (GERTs) are emerging probes of surface-enhanced Raman scattering (SERS) spectroscopy that have found promising analytical, bioimaging, and theranostic applications. Because of their internal location, Raman reporter molecules are protected from unwanted external environments and particle aggregation and demonstrate superior SERS responses owing to the strongly enhanced electromagnetic fields in the gaps between metal core-shell structures. In this review, we discuss recent progress in the synthesis, simulation, and experimental studies of the optical properties and biomedical applications of novel spherically symmetrical and anisotropic GERTs fabricated with common plasmonic metals—gold (Au) and silver (Ag). Our discussion is focused on the design and synthetic strategies that ensure the optimal parameters and highest enhancement factors of GERTs for sensing and theranostics. In particular, we consider various core-shell structures with build-in nanogaps to explain why they would benefit the plasmonic GERTs as a superior SERS tag and how this would help future research in clinical analytics and therapeutics. Ivyspring International Publisher 2020-01-12 /pmc/articles/PMC7019156/ /pubmed/32089735 http://dx.doi.org/10.7150/thno.39968 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Review
Khlebtsov, Nikolai G.
Lin, Li
Khlebtsov, Boris N.
Ye, Jian
Gap-enhanced Raman tags: fabrication, optical properties, and theranostic applications
title Gap-enhanced Raman tags: fabrication, optical properties, and theranostic applications
title_full Gap-enhanced Raman tags: fabrication, optical properties, and theranostic applications
title_fullStr Gap-enhanced Raman tags: fabrication, optical properties, and theranostic applications
title_full_unstemmed Gap-enhanced Raman tags: fabrication, optical properties, and theranostic applications
title_short Gap-enhanced Raman tags: fabrication, optical properties, and theranostic applications
title_sort gap-enhanced raman tags: fabrication, optical properties, and theranostic applications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019156/
https://www.ncbi.nlm.nih.gov/pubmed/32089735
http://dx.doi.org/10.7150/thno.39968
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