Cargando…

IKKε phosphorylates kindlin-2 to induce invadopodia formation and promote colorectal cancer metastasis

Invadopodia formation is a key driver of cancer metastasis. The noncanonical IkB-related kinase IKKε has been implicated in cancer metastasis, but its roles in invadopodia formation and colorectal cancer (CRC) metastasis are unclear. Methods: Immunofluorescence, gelatin-degradation assay, wound heal...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Ge, Bao, Yantao, Liu, Chaohua, Zhu, Qinchang, Zhao, Lin, Lu, Xiaopeng, Zhu, Qian, Lv, Yafei, Bai, Feng, Wen, He, Sun, Yujie, Zhu, Wei-Guo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2020
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019159/ https://www.ncbi.nlm.nih.gov/pubmed/32104508 http://dx.doi.org/10.7150/thno.40397

Ejemplares similares

Phosphorylation of Kindlins and the Control of Integrin Function
por: Bialkowska, Katarzyna, et al.
Publicado: (2021)

Roles for the IKK-Related Kinases TBK1 and IKKε in Cancer
por: Durand, Joel K., et al.
Publicado: (2018)

TBK1 and IKKε prevent TNF-induced cell death by RIPK1 phosphorylation
por: Lafont, Elodie, et al.
Publicado: (2018)

Opposite Role of Kindlin-1 and Kindlin-2 in Lung Cancers
por: Zhan, Jun, et al.
Publicado: (2012)

IKKε and TBK1 expression in gastric cancer
por: Eun Lee, Seung, et al.
Publicado: (2016)

Targeting invadopodia to block breast cancer metastasis
por: Eckert, Mark A., et al.
Publicado: (2011)

PYK2 mediates the BRAF inhibitor (vermurafenib)-induced invadopodia formation and metastasis in melanomas
por: Shen, Junling, et al.
Publicado: (2022)

The role of Tks adaptor proteins in invadopodia formation, growth and metastasis of melanoma
por: Iizuka, Shinji, et al.
Publicado: (2016)

Role of IKKε in the Metabolic Diseases: Physiology, Pathophysiology, and Pharmacology
por: Xiao, Qing-Ao, et al.
Publicado: (2022)

Specification of the NF-κB transcriptional response by p65 phosphorylation and TNF-induced nuclear translocation of IKKε
por: Moreno, Rita, et al.
Publicado: (2010)

Of Kindlins and Cancer
por: Plow, Edward F., et al.
Publicado: (2016)

Targeting HER2(+) breast cancer: the TBK1/IKKε axis
por: Jiang, Zhe, et al.
Publicado: (2014)

Detection of IKKε by immunohistochemistry in primary breast cancer: association with EGFR expression and absence of lymph node metastasis
por: Williams, Virginie, et al.
Publicado: (2017)

The regulation of MMP targeting to invadopodia during cancer metastasis
por: Jacob, Abitha, et al.
Publicado: (2015)

Novel Phosphorylations of IKKγ/NEMO
por: Lee, Sun Hwa, et al.
Publicado: (2012)

IKKε inhibits PKC to promote Fascin-dependent actin bundling
por: Otani, Tetsuhisa, et al.
Publicado: (2016)

Kindlin‐1 drives early steps of breast cancer metastasis
por: Bonin, Florian, et al.
Publicado: (2022)

Kindlin-2 promotes Src-mediated tyrosine phosphorylation of androgen receptor and contributes to breast cancer progression
por: Ma, Luyao, et al.
Publicado: (2022)

Invadopodia in context
por: Bergman, Aviv, et al.
Publicado: (2014)

GIV•Kindlin Interaction Is Required for Kindlin-Mediated Integrin Recognition and Activation
por: Rohena, Cristina, et al.
Publicado: (2020)

Mechanism of integrin activation by talin and its cooperation with kindlin
por: Lu, Fan, et al.
Publicado: (2022)

Site-specific phosphorylation regulates the functions of kindlin-3 in a variety of cells
por: Bialkowska, Katarzyna, et al.
Publicado: (2020)

IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome
por: Thompson, Leslie Michels, et al.
Publicado: (2009)

Dense collagen kindles invadopodia formation
por: Short, Ben
Publicado: (2015)

Non-Coding RNAs in Invadopodia: New Insights Into Cancer Metastasis
por: Li, Feiya, et al.
Publicado: (2021)

Invadopodia enable cooperative invasion and metastasis of breast cancer cells
por: Perrin, Louisiane, et al.
Publicado: (2022)

Inhibition of TBK1/IKKε Promotes Regeneration of Pancreatic β-cells
por: Xu, Jin, et al.
Publicado: (2018)

The breast cancer oncogene IKKε coordinates mitochondrial function and serine metabolism
por: Xu, Ruoyan, et al.
Publicado: (2020)

The TBK1/IKKε inhibitor amlexanox improves dyslipidemia and prevents atherosclerosis
por: Zhao, Peng, et al.
Publicado: (2022)

Parkin ubiquitination of Kindlin-2 enables mitochondria-associated metastasis suppression
por: Yeon, Minjeong, et al.
Publicado: (2023)

IKKε deficiency inhibits acute lung injury following renal ischemia reperfusion injury
por: Meng, Chao, et al.
Publicado: (2020)

IKKε Knockout Prevents High Fat Diet Induced Arterial Atherosclerosis and NF-κB Signaling in Mice
por: Cao, Changchun, et al.
Publicado: (2013)

IKKε and TBK1 in diffuse large B‐cell lymphoma: A possible mechanism of action of an IKKε/TBK1 inhibitor to repress NF‐κB and IL‐10 signalling
por: Carr, Matthew, et al.
Publicado: (2020)

Porcine IKKε is involved in the STING-induced type I IFN antiviral response of the cytosolic DNA signaling pathway
por: Luo, Jia, et al.
Publicado: (2023)

Phylogenetic Analysis of Kindlins Suggests Subfunctionalization of an Ancestral Unduplicated Kindlin into Three Paralogs in Vertebrates
por: Khan, Ammad Aslam, et al.
Publicado: (2011)

Inhibition of invadopodia formation by diosgenin in tumor cells
por: Lian, Yaxin, et al.
Publicado: (2020)

Cortactin function in invadopodia
por: Jeannot, Pauline, et al.
Publicado: (2017)

LPP is a Src substrate required for invadopodia formation and efficient breast cancer lung metastasis
por: Ngan, Elaine, et al.
Publicado: (2017)

Membrane lipids in invadopodia and podosomes: Key structures for cancer invasion and metastasis
por: Yamaguchi, Hideki, et al.
Publicado: (2010)

Development of a High-Throughput Assay for Identifying Inhibitors of TBK1 and IKKε
por: Hutti, Jessica E., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_1b88nk6vrcnjbfp5upfkuc5cgc