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Malignant Insulinoma with Multiple Liver Metastases and Hypercalcitoninemia in a Patient with Type 2 Diabetes Mellitus Presenting as Recurrent Episodes of Diaphoresis due to Severe Hypoglycemia
Insulinoma is an insulin-producing pancreatic neuroendocrine tumor that can be malignant in about 10% of cases. Locoregional invasion, lymph node metastases, or remote metastases are the main criteria of malignant insulinoma. Its incidence in patients with pre-existing diabetes mellitus (DM) is exce...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Hindawi
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019204/ https://www.ncbi.nlm.nih.gov/pubmed/32082648 http://dx.doi.org/10.1155/2020/4239679 |
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author | Ciacciarelli, Marco Caruso, Gianluca Rengo, Marco Maceroni, Piero Misurale, Carmen D'Armiento, Eleonora Polidoro, Alessandro Napoli, Cristina Lombardini, Alberto Ceratti, Umberto Colunga Biancatelli, Ruben Manuel Luciano Calvosa, Leonardo Milanese, Romina Ferri, Sonia Massaro, Teresa Lorusso, Andrea Sorrentino, Veronica Petrozza, Vincenzo Iuliano, Luigi |
author_facet | Ciacciarelli, Marco Caruso, Gianluca Rengo, Marco Maceroni, Piero Misurale, Carmen D'Armiento, Eleonora Polidoro, Alessandro Napoli, Cristina Lombardini, Alberto Ceratti, Umberto Colunga Biancatelli, Ruben Manuel Luciano Calvosa, Leonardo Milanese, Romina Ferri, Sonia Massaro, Teresa Lorusso, Andrea Sorrentino, Veronica Petrozza, Vincenzo Iuliano, Luigi |
author_sort | Ciacciarelli, Marco |
collection | PubMed |
description | Insulinoma is an insulin-producing pancreatic neuroendocrine tumor that can be malignant in about 10% of cases. Locoregional invasion, lymph node metastases, or remote metastases are the main criteria of malignant insulinoma. Its incidence in patients with pre-existing diabetes mellitus (DM) is exceptionally rare. In this report, we describe a 66-year-old man with long-standing type 2 DM who presented with recurrent episodes of diaphoresis due to severe hypoglycemia despite the withdrawal of insulin therapy, hypercalcitoninemia, and biochemical and radiological findings suggestive of metastatic malignant insulinoma. Unfortunately, after few days of diazoxide treatment, edema, hypotension, oliguria, and water retention were observed, patient's clinical status deteriorated rapidly, and he died in our department from acute renal failure. |
format | Online Article Text |
id | pubmed-7019204 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-70192042020-02-20 Malignant Insulinoma with Multiple Liver Metastases and Hypercalcitoninemia in a Patient with Type 2 Diabetes Mellitus Presenting as Recurrent Episodes of Diaphoresis due to Severe Hypoglycemia Ciacciarelli, Marco Caruso, Gianluca Rengo, Marco Maceroni, Piero Misurale, Carmen D'Armiento, Eleonora Polidoro, Alessandro Napoli, Cristina Lombardini, Alberto Ceratti, Umberto Colunga Biancatelli, Ruben Manuel Luciano Calvosa, Leonardo Milanese, Romina Ferri, Sonia Massaro, Teresa Lorusso, Andrea Sorrentino, Veronica Petrozza, Vincenzo Iuliano, Luigi Case Rep Endocrinol Case Report Insulinoma is an insulin-producing pancreatic neuroendocrine tumor that can be malignant in about 10% of cases. Locoregional invasion, lymph node metastases, or remote metastases are the main criteria of malignant insulinoma. Its incidence in patients with pre-existing diabetes mellitus (DM) is exceptionally rare. In this report, we describe a 66-year-old man with long-standing type 2 DM who presented with recurrent episodes of diaphoresis due to severe hypoglycemia despite the withdrawal of insulin therapy, hypercalcitoninemia, and biochemical and radiological findings suggestive of metastatic malignant insulinoma. Unfortunately, after few days of diazoxide treatment, edema, hypotension, oliguria, and water retention were observed, patient's clinical status deteriorated rapidly, and he died in our department from acute renal failure. Hindawi 2020-01-31 /pmc/articles/PMC7019204/ /pubmed/32082648 http://dx.doi.org/10.1155/2020/4239679 Text en Copyright © 2020 Marco Ciacciarelli et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Ciacciarelli, Marco Caruso, Gianluca Rengo, Marco Maceroni, Piero Misurale, Carmen D'Armiento, Eleonora Polidoro, Alessandro Napoli, Cristina Lombardini, Alberto Ceratti, Umberto Colunga Biancatelli, Ruben Manuel Luciano Calvosa, Leonardo Milanese, Romina Ferri, Sonia Massaro, Teresa Lorusso, Andrea Sorrentino, Veronica Petrozza, Vincenzo Iuliano, Luigi Malignant Insulinoma with Multiple Liver Metastases and Hypercalcitoninemia in a Patient with Type 2 Diabetes Mellitus Presenting as Recurrent Episodes of Diaphoresis due to Severe Hypoglycemia |
title | Malignant Insulinoma with Multiple Liver Metastases and Hypercalcitoninemia in a Patient with Type 2 Diabetes Mellitus Presenting as Recurrent Episodes of Diaphoresis due to Severe Hypoglycemia |
title_full | Malignant Insulinoma with Multiple Liver Metastases and Hypercalcitoninemia in a Patient with Type 2 Diabetes Mellitus Presenting as Recurrent Episodes of Diaphoresis due to Severe Hypoglycemia |
title_fullStr | Malignant Insulinoma with Multiple Liver Metastases and Hypercalcitoninemia in a Patient with Type 2 Diabetes Mellitus Presenting as Recurrent Episodes of Diaphoresis due to Severe Hypoglycemia |
title_full_unstemmed | Malignant Insulinoma with Multiple Liver Metastases and Hypercalcitoninemia in a Patient with Type 2 Diabetes Mellitus Presenting as Recurrent Episodes of Diaphoresis due to Severe Hypoglycemia |
title_short | Malignant Insulinoma with Multiple Liver Metastases and Hypercalcitoninemia in a Patient with Type 2 Diabetes Mellitus Presenting as Recurrent Episodes of Diaphoresis due to Severe Hypoglycemia |
title_sort | malignant insulinoma with multiple liver metastases and hypercalcitoninemia in a patient with type 2 diabetes mellitus presenting as recurrent episodes of diaphoresis due to severe hypoglycemia |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019204/ https://www.ncbi.nlm.nih.gov/pubmed/32082648 http://dx.doi.org/10.1155/2020/4239679 |
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