Suppression of DNCB-Induced Atopic Skin Lesions in Mice by Wikstroemia indica Extract

Wikstroemia indica (L.) C.A. Mey. is used in traditional Chinese medicine to treat inflammatory diseases such as arthritis and bronchitis. In this study, we aimed to investigate the effects of an ethanolic extract of W. indica on cutaneous inflammation in mice with 2,4-dinitrochlorobenzene (DNCB)-in...

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Autores principales: Lee, So-Yeon, Park, No-June, Jegal, Jonghwan, Jo, Beom-Geun, Choi, Sangho, Lee, Sang Woo, Uddin, Md. Salah, Kim, Su-Nam, Yang, Min Hye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019247/
https://www.ncbi.nlm.nih.gov/pubmed/31936273
http://dx.doi.org/10.3390/nu12010173
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author Lee, So-Yeon
Park, No-June
Jegal, Jonghwan
Jo, Beom-Geun
Choi, Sangho
Lee, Sang Woo
Uddin, Md. Salah
Kim, Su-Nam
Yang, Min Hye
author_facet Lee, So-Yeon
Park, No-June
Jegal, Jonghwan
Jo, Beom-Geun
Choi, Sangho
Lee, Sang Woo
Uddin, Md. Salah
Kim, Su-Nam
Yang, Min Hye
author_sort Lee, So-Yeon
collection PubMed
description Wikstroemia indica (L.) C.A. Mey. is used in traditional Chinese medicine to treat inflammatory diseases such as arthritis and bronchitis. In this study, we aimed to investigate the effects of an ethanolic extract of W. indica on cutaneous inflammation in mice with 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD). Dermal administration of W. indica ethanolic extract to DNCB-sensitized hairless mice with dermatitis, for two weeks, reduced erythema, scaling, and edema. Skin hydration was improved and transepidermal water loss was reduced at a W. indica concentration of 1%. Furthermore, W. indica also significantly reduced serum IgE and IL-4 concentrations in our mouse model. These results suggest that W. indica has potential as a topical treatment for AD and as an adjunctive agent to control AD.
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spelling pubmed-70192472020-03-04 Suppression of DNCB-Induced Atopic Skin Lesions in Mice by Wikstroemia indica Extract Lee, So-Yeon Park, No-June Jegal, Jonghwan Jo, Beom-Geun Choi, Sangho Lee, Sang Woo Uddin, Md. Salah Kim, Su-Nam Yang, Min Hye Nutrients Article Wikstroemia indica (L.) C.A. Mey. is used in traditional Chinese medicine to treat inflammatory diseases such as arthritis and bronchitis. In this study, we aimed to investigate the effects of an ethanolic extract of W. indica on cutaneous inflammation in mice with 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD). Dermal administration of W. indica ethanolic extract to DNCB-sensitized hairless mice with dermatitis, for two weeks, reduced erythema, scaling, and edema. Skin hydration was improved and transepidermal water loss was reduced at a W. indica concentration of 1%. Furthermore, W. indica also significantly reduced serum IgE and IL-4 concentrations in our mouse model. These results suggest that W. indica has potential as a topical treatment for AD and as an adjunctive agent to control AD. MDPI 2020-01-08 /pmc/articles/PMC7019247/ /pubmed/31936273 http://dx.doi.org/10.3390/nu12010173 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lee, So-Yeon
Park, No-June
Jegal, Jonghwan
Jo, Beom-Geun
Choi, Sangho
Lee, Sang Woo
Uddin, Md. Salah
Kim, Su-Nam
Yang, Min Hye
Suppression of DNCB-Induced Atopic Skin Lesions in Mice by Wikstroemia indica Extract
title Suppression of DNCB-Induced Atopic Skin Lesions in Mice by Wikstroemia indica Extract
title_full Suppression of DNCB-Induced Atopic Skin Lesions in Mice by Wikstroemia indica Extract
title_fullStr Suppression of DNCB-Induced Atopic Skin Lesions in Mice by Wikstroemia indica Extract
title_full_unstemmed Suppression of DNCB-Induced Atopic Skin Lesions in Mice by Wikstroemia indica Extract
title_short Suppression of DNCB-Induced Atopic Skin Lesions in Mice by Wikstroemia indica Extract
title_sort suppression of dncb-induced atopic skin lesions in mice by wikstroemia indica extract
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019247/
https://www.ncbi.nlm.nih.gov/pubmed/31936273
http://dx.doi.org/10.3390/nu12010173
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