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Intestinal Fructose and Glucose Metabolism in Health and Disease
The worldwide epidemics of obesity and diabetes have been linked to increased sugar consumption in humans. Here, we review fructose and glucose metabolism, as well as potential molecular mechanisms by which excessive sugar consumption is associated to metabolic diseases and insulin resistance in hum...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019254/ https://www.ncbi.nlm.nih.gov/pubmed/31905727 http://dx.doi.org/10.3390/nu12010094 |
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author | Merino, Beatriz Fernández-Díaz, Cristina M. Cózar-Castellano, Irene Perdomo, German |
author_facet | Merino, Beatriz Fernández-Díaz, Cristina M. Cózar-Castellano, Irene Perdomo, German |
author_sort | Merino, Beatriz |
collection | PubMed |
description | The worldwide epidemics of obesity and diabetes have been linked to increased sugar consumption in humans. Here, we review fructose and glucose metabolism, as well as potential molecular mechanisms by which excessive sugar consumption is associated to metabolic diseases and insulin resistance in humans. To this end, we focus on understanding molecular and cellular mechanisms of fructose and glucose transport and sensing in the intestine, the intracellular signaling effects of dietary sugar metabolism, and its impact on glucose homeostasis in health and disease. Finally, the peripheral and central effects of dietary sugars on the gut–brain axis will be reviewed. |
format | Online Article Text |
id | pubmed-7019254 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-70192542020-03-04 Intestinal Fructose and Glucose Metabolism in Health and Disease Merino, Beatriz Fernández-Díaz, Cristina M. Cózar-Castellano, Irene Perdomo, German Nutrients Review The worldwide epidemics of obesity and diabetes have been linked to increased sugar consumption in humans. Here, we review fructose and glucose metabolism, as well as potential molecular mechanisms by which excessive sugar consumption is associated to metabolic diseases and insulin resistance in humans. To this end, we focus on understanding molecular and cellular mechanisms of fructose and glucose transport and sensing in the intestine, the intracellular signaling effects of dietary sugar metabolism, and its impact on glucose homeostasis in health and disease. Finally, the peripheral and central effects of dietary sugars on the gut–brain axis will be reviewed. MDPI 2019-12-29 /pmc/articles/PMC7019254/ /pubmed/31905727 http://dx.doi.org/10.3390/nu12010094 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Merino, Beatriz Fernández-Díaz, Cristina M. Cózar-Castellano, Irene Perdomo, German Intestinal Fructose and Glucose Metabolism in Health and Disease |
title | Intestinal Fructose and Glucose Metabolism in Health and Disease |
title_full | Intestinal Fructose and Glucose Metabolism in Health and Disease |
title_fullStr | Intestinal Fructose and Glucose Metabolism in Health and Disease |
title_full_unstemmed | Intestinal Fructose and Glucose Metabolism in Health and Disease |
title_short | Intestinal Fructose and Glucose Metabolism in Health and Disease |
title_sort | intestinal fructose and glucose metabolism in health and disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019254/ https://www.ncbi.nlm.nih.gov/pubmed/31905727 http://dx.doi.org/10.3390/nu12010094 |
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