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Intestinal Fructose and Glucose Metabolism in Health and Disease

The worldwide epidemics of obesity and diabetes have been linked to increased sugar consumption in humans. Here, we review fructose and glucose metabolism, as well as potential molecular mechanisms by which excessive sugar consumption is associated to metabolic diseases and insulin resistance in hum...

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Autores principales: Merino, Beatriz, Fernández-Díaz, Cristina M., Cózar-Castellano, Irene, Perdomo, German
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019254/
https://www.ncbi.nlm.nih.gov/pubmed/31905727
http://dx.doi.org/10.3390/nu12010094
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author Merino, Beatriz
Fernández-Díaz, Cristina M.
Cózar-Castellano, Irene
Perdomo, German
author_facet Merino, Beatriz
Fernández-Díaz, Cristina M.
Cózar-Castellano, Irene
Perdomo, German
author_sort Merino, Beatriz
collection PubMed
description The worldwide epidemics of obesity and diabetes have been linked to increased sugar consumption in humans. Here, we review fructose and glucose metabolism, as well as potential molecular mechanisms by which excessive sugar consumption is associated to metabolic diseases and insulin resistance in humans. To this end, we focus on understanding molecular and cellular mechanisms of fructose and glucose transport and sensing in the intestine, the intracellular signaling effects of dietary sugar metabolism, and its impact on glucose homeostasis in health and disease. Finally, the peripheral and central effects of dietary sugars on the gut–brain axis will be reviewed.
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spelling pubmed-70192542020-03-04 Intestinal Fructose and Glucose Metabolism in Health and Disease Merino, Beatriz Fernández-Díaz, Cristina M. Cózar-Castellano, Irene Perdomo, German Nutrients Review The worldwide epidemics of obesity and diabetes have been linked to increased sugar consumption in humans. Here, we review fructose and glucose metabolism, as well as potential molecular mechanisms by which excessive sugar consumption is associated to metabolic diseases and insulin resistance in humans. To this end, we focus on understanding molecular and cellular mechanisms of fructose and glucose transport and sensing in the intestine, the intracellular signaling effects of dietary sugar metabolism, and its impact on glucose homeostasis in health and disease. Finally, the peripheral and central effects of dietary sugars on the gut–brain axis will be reviewed. MDPI 2019-12-29 /pmc/articles/PMC7019254/ /pubmed/31905727 http://dx.doi.org/10.3390/nu12010094 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Merino, Beatriz
Fernández-Díaz, Cristina M.
Cózar-Castellano, Irene
Perdomo, German
Intestinal Fructose and Glucose Metabolism in Health and Disease
title Intestinal Fructose and Glucose Metabolism in Health and Disease
title_full Intestinal Fructose and Glucose Metabolism in Health and Disease
title_fullStr Intestinal Fructose and Glucose Metabolism in Health and Disease
title_full_unstemmed Intestinal Fructose and Glucose Metabolism in Health and Disease
title_short Intestinal Fructose and Glucose Metabolism in Health and Disease
title_sort intestinal fructose and glucose metabolism in health and disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019254/
https://www.ncbi.nlm.nih.gov/pubmed/31905727
http://dx.doi.org/10.3390/nu12010094
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