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Multi-Approach Investigation Regarding the West Nile Virus Situation in Hungary, 2018

The West Nile virus is endemic in multiple European countries and responsible for several epidemics throughout the European region. Its evolution into local or even widespread epidemics is driven by multiple factors from genetic diversification of the virus to environmental conditions. The year of 2...

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Autores principales: Zana, Brigitta, Erdélyi, Károly, Nagy, Anna, Mezei, Eszter, Nagy, Orsolya, Takács, Mária, Bakonyi, Tamás, Forgách, Petra, Korbacska-Kutasi, Orsolya, Fehér, Orsolya, Malik, Péter, Ursu, Krisztina, Kertész, Péter, Kepner, Anett, Martina, Máté, Süli, Tamás, Lanszki, Zsófia, Tóth, Gábor Endre, Kuczmog, Anett, Somogyi, Balázs, Jakab, Ferenc, Kemenesi, Gábor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019302/
https://www.ncbi.nlm.nih.gov/pubmed/31968613
http://dx.doi.org/10.3390/v12010123
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author Zana, Brigitta
Erdélyi, Károly
Nagy, Anna
Mezei, Eszter
Nagy, Orsolya
Takács, Mária
Bakonyi, Tamás
Forgách, Petra
Korbacska-Kutasi, Orsolya
Fehér, Orsolya
Malik, Péter
Ursu, Krisztina
Kertész, Péter
Kepner, Anett
Martina, Máté
Süli, Tamás
Lanszki, Zsófia
Tóth, Gábor Endre
Kuczmog, Anett
Somogyi, Balázs
Jakab, Ferenc
Kemenesi, Gábor
author_facet Zana, Brigitta
Erdélyi, Károly
Nagy, Anna
Mezei, Eszter
Nagy, Orsolya
Takács, Mária
Bakonyi, Tamás
Forgách, Petra
Korbacska-Kutasi, Orsolya
Fehér, Orsolya
Malik, Péter
Ursu, Krisztina
Kertész, Péter
Kepner, Anett
Martina, Máté
Süli, Tamás
Lanszki, Zsófia
Tóth, Gábor Endre
Kuczmog, Anett
Somogyi, Balázs
Jakab, Ferenc
Kemenesi, Gábor
author_sort Zana, Brigitta
collection PubMed
description The West Nile virus is endemic in multiple European countries and responsible for several epidemics throughout the European region. Its evolution into local or even widespread epidemics is driven by multiple factors from genetic diversification of the virus to environmental conditions. The year of 2018 was characterized by an extraordinary increase in human and animal cases in the Central-Eastern European region, including Hungary. In a collaborative effort, we summarized and analyzed the genetic and serologic data of WNV infections from multiple Hungarian public health institutions, universities, and private organizations. We compared human and veterinary serologic data, along with NS5 and NS3 gene sequence data through 2018. Wild birds were excellent indicator species for WNV circulation in each year. Our efforts resulted in documenting the presence of multiple phylogenetic subclades with Balkans and Western-European progenitor sequences of WNV circulating among human and animal populations in Hungary prior to and during the 2018 epidemic. Supported by our sequence and phylogenetic data, the epidemic of 2018 was not caused by recently introduced WNV strains. Unfortunately, Hungary has no country-wide integrated surveillance system which would enable the analysis of related conditions and provide a comprehensive epidemiological picture. The One Health approach, involving multiple institutions and experts, should be implemented in order to fully understand ecological background factors driving the evolution of future epidemics.
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spelling pubmed-70193022020-03-04 Multi-Approach Investigation Regarding the West Nile Virus Situation in Hungary, 2018 Zana, Brigitta Erdélyi, Károly Nagy, Anna Mezei, Eszter Nagy, Orsolya Takács, Mária Bakonyi, Tamás Forgách, Petra Korbacska-Kutasi, Orsolya Fehér, Orsolya Malik, Péter Ursu, Krisztina Kertész, Péter Kepner, Anett Martina, Máté Süli, Tamás Lanszki, Zsófia Tóth, Gábor Endre Kuczmog, Anett Somogyi, Balázs Jakab, Ferenc Kemenesi, Gábor Viruses Brief Report The West Nile virus is endemic in multiple European countries and responsible for several epidemics throughout the European region. Its evolution into local or even widespread epidemics is driven by multiple factors from genetic diversification of the virus to environmental conditions. The year of 2018 was characterized by an extraordinary increase in human and animal cases in the Central-Eastern European region, including Hungary. In a collaborative effort, we summarized and analyzed the genetic and serologic data of WNV infections from multiple Hungarian public health institutions, universities, and private organizations. We compared human and veterinary serologic data, along with NS5 and NS3 gene sequence data through 2018. Wild birds were excellent indicator species for WNV circulation in each year. Our efforts resulted in documenting the presence of multiple phylogenetic subclades with Balkans and Western-European progenitor sequences of WNV circulating among human and animal populations in Hungary prior to and during the 2018 epidemic. Supported by our sequence and phylogenetic data, the epidemic of 2018 was not caused by recently introduced WNV strains. Unfortunately, Hungary has no country-wide integrated surveillance system which would enable the analysis of related conditions and provide a comprehensive epidemiological picture. The One Health approach, involving multiple institutions and experts, should be implemented in order to fully understand ecological background factors driving the evolution of future epidemics. MDPI 2020-01-20 /pmc/articles/PMC7019302/ /pubmed/31968613 http://dx.doi.org/10.3390/v12010123 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Zana, Brigitta
Erdélyi, Károly
Nagy, Anna
Mezei, Eszter
Nagy, Orsolya
Takács, Mária
Bakonyi, Tamás
Forgách, Petra
Korbacska-Kutasi, Orsolya
Fehér, Orsolya
Malik, Péter
Ursu, Krisztina
Kertész, Péter
Kepner, Anett
Martina, Máté
Süli, Tamás
Lanszki, Zsófia
Tóth, Gábor Endre
Kuczmog, Anett
Somogyi, Balázs
Jakab, Ferenc
Kemenesi, Gábor
Multi-Approach Investigation Regarding the West Nile Virus Situation in Hungary, 2018
title Multi-Approach Investigation Regarding the West Nile Virus Situation in Hungary, 2018
title_full Multi-Approach Investigation Regarding the West Nile Virus Situation in Hungary, 2018
title_fullStr Multi-Approach Investigation Regarding the West Nile Virus Situation in Hungary, 2018
title_full_unstemmed Multi-Approach Investigation Regarding the West Nile Virus Situation in Hungary, 2018
title_short Multi-Approach Investigation Regarding the West Nile Virus Situation in Hungary, 2018
title_sort multi-approach investigation regarding the west nile virus situation in hungary, 2018
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019302/
https://www.ncbi.nlm.nih.gov/pubmed/31968613
http://dx.doi.org/10.3390/v12010123
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