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Assessment of the Minimal Targeted Biopsy Core Number per MRI Lesion for Improving Prostate Cancer Grading Prediction
Background: To study the impact of MRI characteristics and of targeted biopsy (TB) core number on the final grade group (GG) prediction. Materials and Methods: The cohort was 478 consecutive patients who underwent radical prostatectomy (RP) after positive mpMRI (multiparametric magnetic resonance im...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019328/ https://www.ncbi.nlm.nih.gov/pubmed/31952120 http://dx.doi.org/10.3390/jcm9010225 |
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author | Ploussard, Guillaume Beauval, Jean-Baptiste Renard-Penna, Raphaële Lesourd, Marine Manceau, Cécile Almeras, Christophe Gautier, Jean-Romain Loison, Guillaume Portalez, Daniel Salin, Ambroise Soulié, Michel Tollon, Christophe Malavaud, Bernard Roumiguié, Mathieu |
author_facet | Ploussard, Guillaume Beauval, Jean-Baptiste Renard-Penna, Raphaële Lesourd, Marine Manceau, Cécile Almeras, Christophe Gautier, Jean-Romain Loison, Guillaume Portalez, Daniel Salin, Ambroise Soulié, Michel Tollon, Christophe Malavaud, Bernard Roumiguié, Mathieu |
author_sort | Ploussard, Guillaume |
collection | PubMed |
description | Background: To study the impact of MRI characteristics and of targeted biopsy (TB) core number on the final grade group (GG) prediction. Materials and Methods: The cohort was 478 consecutive patients who underwent radical prostatectomy (RP) after positive mpMRI (multiparametric magnetic resonance imaging) followed by fusion TB. Endpoints were the upgrading and concordance rates between TB and RP specimens. Results: Upgrading rate after TB was 40.6%. Patients with upgrading had lower PIRADS (Prostate Imaging-Reporting and Data System) scores (p < 0.001), smaller lesion size (p = 0.017), fewer TB cores (p < 0.001), and lower TB density (p = 0.015) compared with cases with grade concordance. There was a significant continuous improvement in upgrading rate when TB core number per lesion increased from 56.3% to 25.6% when <2 or ≥5 TB cores were taken, respectively (p = 0.002). The minimal TB number per lesion to reduce upgrading risk to approximately 30%was 4 in PIRADS 3, and 3 in PIRADS 4–5 cases. Conclusions: Grade group prediction by TB is significantly improved by higher PIRADS score, larger lesion size, and increased TB per lesion. At least four TB cores should be taken in PIRADS 3 score lesions, whereas three cores seem enough in PIRADS 4–5 cases to improve GG prediction and limit upgrading risk. |
format | Online Article Text |
id | pubmed-7019328 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-70193282020-03-09 Assessment of the Minimal Targeted Biopsy Core Number per MRI Lesion for Improving Prostate Cancer Grading Prediction Ploussard, Guillaume Beauval, Jean-Baptiste Renard-Penna, Raphaële Lesourd, Marine Manceau, Cécile Almeras, Christophe Gautier, Jean-Romain Loison, Guillaume Portalez, Daniel Salin, Ambroise Soulié, Michel Tollon, Christophe Malavaud, Bernard Roumiguié, Mathieu J Clin Med Article Background: To study the impact of MRI characteristics and of targeted biopsy (TB) core number on the final grade group (GG) prediction. Materials and Methods: The cohort was 478 consecutive patients who underwent radical prostatectomy (RP) after positive mpMRI (multiparametric magnetic resonance imaging) followed by fusion TB. Endpoints were the upgrading and concordance rates between TB and RP specimens. Results: Upgrading rate after TB was 40.6%. Patients with upgrading had lower PIRADS (Prostate Imaging-Reporting and Data System) scores (p < 0.001), smaller lesion size (p = 0.017), fewer TB cores (p < 0.001), and lower TB density (p = 0.015) compared with cases with grade concordance. There was a significant continuous improvement in upgrading rate when TB core number per lesion increased from 56.3% to 25.6% when <2 or ≥5 TB cores were taken, respectively (p = 0.002). The minimal TB number per lesion to reduce upgrading risk to approximately 30%was 4 in PIRADS 3, and 3 in PIRADS 4–5 cases. Conclusions: Grade group prediction by TB is significantly improved by higher PIRADS score, larger lesion size, and increased TB per lesion. At least four TB cores should be taken in PIRADS 3 score lesions, whereas three cores seem enough in PIRADS 4–5 cases to improve GG prediction and limit upgrading risk. MDPI 2020-01-15 /pmc/articles/PMC7019328/ /pubmed/31952120 http://dx.doi.org/10.3390/jcm9010225 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Ploussard, Guillaume Beauval, Jean-Baptiste Renard-Penna, Raphaële Lesourd, Marine Manceau, Cécile Almeras, Christophe Gautier, Jean-Romain Loison, Guillaume Portalez, Daniel Salin, Ambroise Soulié, Michel Tollon, Christophe Malavaud, Bernard Roumiguié, Mathieu Assessment of the Minimal Targeted Biopsy Core Number per MRI Lesion for Improving Prostate Cancer Grading Prediction |
title | Assessment of the Minimal Targeted Biopsy Core Number per MRI Lesion for Improving Prostate Cancer Grading Prediction |
title_full | Assessment of the Minimal Targeted Biopsy Core Number per MRI Lesion for Improving Prostate Cancer Grading Prediction |
title_fullStr | Assessment of the Minimal Targeted Biopsy Core Number per MRI Lesion for Improving Prostate Cancer Grading Prediction |
title_full_unstemmed | Assessment of the Minimal Targeted Biopsy Core Number per MRI Lesion for Improving Prostate Cancer Grading Prediction |
title_short | Assessment of the Minimal Targeted Biopsy Core Number per MRI Lesion for Improving Prostate Cancer Grading Prediction |
title_sort | assessment of the minimal targeted biopsy core number per mri lesion for improving prostate cancer grading prediction |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019328/ https://www.ncbi.nlm.nih.gov/pubmed/31952120 http://dx.doi.org/10.3390/jcm9010225 |
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