Cargando…

Application of a Terahertz System Combined with an X-Shaped Metamaterial Microfluidic Cartridge

Terahertz (THz) radiation has attracted wide attention for its ability to sense molecular structure and chemical matter because of a label-free molecular fingerprint and nondestructive properties. When it comes to molecular recognition with terahertz radiation, our attention goes first towards the a...

Descripción completa

Detalles Bibliográficos
Autores principales: Huang, Shih-Ting, Hsu, Shen-Fu, Tang, Kai-Yuan, Yen, Ta-Jen, Yao, Da-Jeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019364/
https://www.ncbi.nlm.nih.gov/pubmed/31936637
http://dx.doi.org/10.3390/mi11010074
_version_ 1783497508053319680
author Huang, Shih-Ting
Hsu, Shen-Fu
Tang, Kai-Yuan
Yen, Ta-Jen
Yao, Da-Jeng
author_facet Huang, Shih-Ting
Hsu, Shen-Fu
Tang, Kai-Yuan
Yen, Ta-Jen
Yao, Da-Jeng
author_sort Huang, Shih-Ting
collection PubMed
description Terahertz (THz) radiation has attracted wide attention for its ability to sense molecular structure and chemical matter because of a label-free molecular fingerprint and nondestructive properties. When it comes to molecular recognition with terahertz radiation, our attention goes first towards the absorption spectrum, which is beyond the far infrared region. To enhance the sensitivity for similar species, however, it is necessary to apply an artificially designed metamaterial sensor for detection, which confines an electromagnetic field in an extremely sub-wavelength space and hence receives an electromagnetic response through resonance. Once the resonance is caused through the interaction between the THz radiation and the metamaterial, a minute variation might be observed in the frequency domain. For a geometric structure of a metamaterial, a novel design called an X-shaped plasmonic sensor (XPS) can create a quadrupole resonance and lead to sensitivity greater than in the dipole mode. A microfluidic system is able to consume reagents in small volumes for detection, to diminish noise from the environment, and to concentrate the sample into detection spots. A microfluidic device integrated with an X-shaped plasmonic sensor might thus achieve an effective and highly sensitive detection cartridge. Our tests involved not only measurements of liquid samples, but also the performance of a dry bio-sample coated on an XPS.
format Online
Article
Text
id pubmed-7019364
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-70193642020-03-09 Application of a Terahertz System Combined with an X-Shaped Metamaterial Microfluidic Cartridge Huang, Shih-Ting Hsu, Shen-Fu Tang, Kai-Yuan Yen, Ta-Jen Yao, Da-Jeng Micromachines (Basel) Article Terahertz (THz) radiation has attracted wide attention for its ability to sense molecular structure and chemical matter because of a label-free molecular fingerprint and nondestructive properties. When it comes to molecular recognition with terahertz radiation, our attention goes first towards the absorption spectrum, which is beyond the far infrared region. To enhance the sensitivity for similar species, however, it is necessary to apply an artificially designed metamaterial sensor for detection, which confines an electromagnetic field in an extremely sub-wavelength space and hence receives an electromagnetic response through resonance. Once the resonance is caused through the interaction between the THz radiation and the metamaterial, a minute variation might be observed in the frequency domain. For a geometric structure of a metamaterial, a novel design called an X-shaped plasmonic sensor (XPS) can create a quadrupole resonance and lead to sensitivity greater than in the dipole mode. A microfluidic system is able to consume reagents in small volumes for detection, to diminish noise from the environment, and to concentrate the sample into detection spots. A microfluidic device integrated with an X-shaped plasmonic sensor might thus achieve an effective and highly sensitive detection cartridge. Our tests involved not only measurements of liquid samples, but also the performance of a dry bio-sample coated on an XPS. MDPI 2020-01-09 /pmc/articles/PMC7019364/ /pubmed/31936637 http://dx.doi.org/10.3390/mi11010074 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Huang, Shih-Ting
Hsu, Shen-Fu
Tang, Kai-Yuan
Yen, Ta-Jen
Yao, Da-Jeng
Application of a Terahertz System Combined with an X-Shaped Metamaterial Microfluidic Cartridge
title Application of a Terahertz System Combined with an X-Shaped Metamaterial Microfluidic Cartridge
title_full Application of a Terahertz System Combined with an X-Shaped Metamaterial Microfluidic Cartridge
title_fullStr Application of a Terahertz System Combined with an X-Shaped Metamaterial Microfluidic Cartridge
title_full_unstemmed Application of a Terahertz System Combined with an X-Shaped Metamaterial Microfluidic Cartridge
title_short Application of a Terahertz System Combined with an X-Shaped Metamaterial Microfluidic Cartridge
title_sort application of a terahertz system combined with an x-shaped metamaterial microfluidic cartridge
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019364/
https://www.ncbi.nlm.nih.gov/pubmed/31936637
http://dx.doi.org/10.3390/mi11010074
work_keys_str_mv AT huangshihting applicationofaterahertzsystemcombinedwithanxshapedmetamaterialmicrofluidiccartridge
AT hsushenfu applicationofaterahertzsystemcombinedwithanxshapedmetamaterialmicrofluidiccartridge
AT tangkaiyuan applicationofaterahertzsystemcombinedwithanxshapedmetamaterialmicrofluidiccartridge
AT yentajen applicationofaterahertzsystemcombinedwithanxshapedmetamaterialmicrofluidiccartridge
AT yaodajeng applicationofaterahertzsystemcombinedwithanxshapedmetamaterialmicrofluidiccartridge