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A Review of the Immunomodulating Components of Maternal Breast Milk and Protection Against Necrotizing Enterocolitis

Breast milk contains immunomodulating components that are beneficial to newborns during maturation of their immune system. Human breast milk composition is influenced by an infant’s gestational and chronological age, lactation stage, and the mother and infant’s health status. Major immunologic compo...

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Detalles Bibliográficos
Autores principales: Nolan, Lila S., Parks, Olivia B., Good, Misty
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019368/
https://www.ncbi.nlm.nih.gov/pubmed/31861718
http://dx.doi.org/10.3390/nu12010014
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author Nolan, Lila S.
Parks, Olivia B.
Good, Misty
author_facet Nolan, Lila S.
Parks, Olivia B.
Good, Misty
author_sort Nolan, Lila S.
collection PubMed
description Breast milk contains immunomodulating components that are beneficial to newborns during maturation of their immune system. Human breast milk composition is influenced by an infant’s gestational and chronological age, lactation stage, and the mother and infant’s health status. Major immunologic components in human milk, such as secretory immunoglobulin A (IgA) and growth factors, have a known role in regulating gut barrier integrity and microbial colonization, which therefore protect against the development of a life-threatening gastrointestinal illness affecting newborn infants called necrotizing enterocolitis (NEC). Breast milk is a known protective factor in the prevention of NEC when compared with feeding with commercial formula. Breast milk supplements infants with human milk oligosaccharides, leukocytes, cytokines, nitric oxide, and growth factors that attenuate inflammatory responses and provide immunological defenses to reduce the incidence of NEC. This article aims to review the variety of immunomodulating components in breast milk that protect the infant from the development of NEC.
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spelling pubmed-70193682020-03-09 A Review of the Immunomodulating Components of Maternal Breast Milk and Protection Against Necrotizing Enterocolitis Nolan, Lila S. Parks, Olivia B. Good, Misty Nutrients Review Breast milk contains immunomodulating components that are beneficial to newborns during maturation of their immune system. Human breast milk composition is influenced by an infant’s gestational and chronological age, lactation stage, and the mother and infant’s health status. Major immunologic components in human milk, such as secretory immunoglobulin A (IgA) and growth factors, have a known role in regulating gut barrier integrity and microbial colonization, which therefore protect against the development of a life-threatening gastrointestinal illness affecting newborn infants called necrotizing enterocolitis (NEC). Breast milk is a known protective factor in the prevention of NEC when compared with feeding with commercial formula. Breast milk supplements infants with human milk oligosaccharides, leukocytes, cytokines, nitric oxide, and growth factors that attenuate inflammatory responses and provide immunological defenses to reduce the incidence of NEC. This article aims to review the variety of immunomodulating components in breast milk that protect the infant from the development of NEC. MDPI 2019-12-19 /pmc/articles/PMC7019368/ /pubmed/31861718 http://dx.doi.org/10.3390/nu12010014 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Nolan, Lila S.
Parks, Olivia B.
Good, Misty
A Review of the Immunomodulating Components of Maternal Breast Milk and Protection Against Necrotizing Enterocolitis
title A Review of the Immunomodulating Components of Maternal Breast Milk and Protection Against Necrotizing Enterocolitis
title_full A Review of the Immunomodulating Components of Maternal Breast Milk and Protection Against Necrotizing Enterocolitis
title_fullStr A Review of the Immunomodulating Components of Maternal Breast Milk and Protection Against Necrotizing Enterocolitis
title_full_unstemmed A Review of the Immunomodulating Components of Maternal Breast Milk and Protection Against Necrotizing Enterocolitis
title_short A Review of the Immunomodulating Components of Maternal Breast Milk and Protection Against Necrotizing Enterocolitis
title_sort review of the immunomodulating components of maternal breast milk and protection against necrotizing enterocolitis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019368/
https://www.ncbi.nlm.nih.gov/pubmed/31861718
http://dx.doi.org/10.3390/nu12010014
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