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The Effects of Hyperuricemia on the Prognosis of IgA Nephropathy are More Potent in Females

Hyperuricemia is a potential risk factor for immunoglobulin A nephropathy (IgAN) progression but its sex-specific effects on IgAN progression remain unclear. This study aimed to determine the effect of serum uric acid on IgAN progression and whether its effect varied according to sex. A total of 433...

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Autores principales: Oh, Tae Ryom, Choi, Hong Sang, Kim, Chang Seong, Kang, Kyung Pyo, Kwon, Young Joo, Kim, Sung Gyun, Ma, Seong Kwon, Kim, Soo Wan, Bae, Eun Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019531/
https://www.ncbi.nlm.nih.gov/pubmed/31936416
http://dx.doi.org/10.3390/jcm9010176
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author Oh, Tae Ryom
Choi, Hong Sang
Kim, Chang Seong
Kang, Kyung Pyo
Kwon, Young Joo
Kim, Sung Gyun
Ma, Seong Kwon
Kim, Soo Wan
Bae, Eun Hui
author_facet Oh, Tae Ryom
Choi, Hong Sang
Kim, Chang Seong
Kang, Kyung Pyo
Kwon, Young Joo
Kim, Sung Gyun
Ma, Seong Kwon
Kim, Soo Wan
Bae, Eun Hui
author_sort Oh, Tae Ryom
collection PubMed
description Hyperuricemia is a potential risk factor for immunoglobulin A nephropathy (IgAN) progression but its sex-specific effects on IgAN progression remain unclear. This study aimed to determine the effect of serum uric acid on IgAN progression and whether its effect varied according to sex. A total of 4339 patients who diagnosed with IgAN by renal biopsy were retrospectively analyzed. We assessed the association of serum uric acid on IgAN progression using Kaplan–Meier survival analyses and Cox proportional hazards models. The study’s primary end point was IgAN progression that was defined as a 50% decline in the estimated glomerular filtration rate or the initiation of dialysis. On average, the serum uric acid levels were higher in the men than in the women. In the fully adjusted Cox proportional hazards model that considered all subjects, the risk of IgAN progression increased by about 25.6% for every 1 mg/dL increase in the baseline uric acid level. The serum uric acid level was an independent risk factor for IgAN progression in both sexes but its effect was more pronounced in the women (hazard ratio [HR], 1.383; confidence interval [CI],1.263 to 1.514; p < 0.001) than in the men (HR, 1.181; CI, 1.097 to 1.272; p < 0.001) (p(interaction) < 0.001). A sensitivity analysis involving serum uric acid quartiles generated consistent and robust results. In conclusion, the serum uric acid level was an independent risk factor for IgAN progression and its effect was more pronounced among the women compared with that among the men.
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spelling pubmed-70195312020-03-09 The Effects of Hyperuricemia on the Prognosis of IgA Nephropathy are More Potent in Females Oh, Tae Ryom Choi, Hong Sang Kim, Chang Seong Kang, Kyung Pyo Kwon, Young Joo Kim, Sung Gyun Ma, Seong Kwon Kim, Soo Wan Bae, Eun Hui J Clin Med Article Hyperuricemia is a potential risk factor for immunoglobulin A nephropathy (IgAN) progression but its sex-specific effects on IgAN progression remain unclear. This study aimed to determine the effect of serum uric acid on IgAN progression and whether its effect varied according to sex. A total of 4339 patients who diagnosed with IgAN by renal biopsy were retrospectively analyzed. We assessed the association of serum uric acid on IgAN progression using Kaplan–Meier survival analyses and Cox proportional hazards models. The study’s primary end point was IgAN progression that was defined as a 50% decline in the estimated glomerular filtration rate or the initiation of dialysis. On average, the serum uric acid levels were higher in the men than in the women. In the fully adjusted Cox proportional hazards model that considered all subjects, the risk of IgAN progression increased by about 25.6% for every 1 mg/dL increase in the baseline uric acid level. The serum uric acid level was an independent risk factor for IgAN progression in both sexes but its effect was more pronounced in the women (hazard ratio [HR], 1.383; confidence interval [CI],1.263 to 1.514; p < 0.001) than in the men (HR, 1.181; CI, 1.097 to 1.272; p < 0.001) (p(interaction) < 0.001). A sensitivity analysis involving serum uric acid quartiles generated consistent and robust results. In conclusion, the serum uric acid level was an independent risk factor for IgAN progression and its effect was more pronounced among the women compared with that among the men. MDPI 2020-01-08 /pmc/articles/PMC7019531/ /pubmed/31936416 http://dx.doi.org/10.3390/jcm9010176 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Oh, Tae Ryom
Choi, Hong Sang
Kim, Chang Seong
Kang, Kyung Pyo
Kwon, Young Joo
Kim, Sung Gyun
Ma, Seong Kwon
Kim, Soo Wan
Bae, Eun Hui
The Effects of Hyperuricemia on the Prognosis of IgA Nephropathy are More Potent in Females
title The Effects of Hyperuricemia on the Prognosis of IgA Nephropathy are More Potent in Females
title_full The Effects of Hyperuricemia on the Prognosis of IgA Nephropathy are More Potent in Females
title_fullStr The Effects of Hyperuricemia on the Prognosis of IgA Nephropathy are More Potent in Females
title_full_unstemmed The Effects of Hyperuricemia on the Prognosis of IgA Nephropathy are More Potent in Females
title_short The Effects of Hyperuricemia on the Prognosis of IgA Nephropathy are More Potent in Females
title_sort effects of hyperuricemia on the prognosis of iga nephropathy are more potent in females
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019531/
https://www.ncbi.nlm.nih.gov/pubmed/31936416
http://dx.doi.org/10.3390/jcm9010176
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