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Clear Cell Adenocarcinoma of the Urinary Bladder Is a Glycogen-Rich Tumor with Poorer Prognosis

Clear cell adenocarcinoma (CCA) is a rare variant of urinary bladder carcinoma with a glycogen-rich phenotype and unknown prognosis. Using the National Cancer Institute’s surveillance, epidemiology, and end results (SEER) program database, we documented recent trends in incidence, mortality, demogra...

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Autores principales: Zhou, Zhengqiu, Kinslow, Connor J., Wang, Peng, Huang, Bin, Cheng, Simon K., Deutsch, Israel, Gentry, Matthew S., Sun, Ramon C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019566/
https://www.ncbi.nlm.nih.gov/pubmed/31947882
http://dx.doi.org/10.3390/jcm9010138
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author Zhou, Zhengqiu
Kinslow, Connor J.
Wang, Peng
Huang, Bin
Cheng, Simon K.
Deutsch, Israel
Gentry, Matthew S.
Sun, Ramon C.
author_facet Zhou, Zhengqiu
Kinslow, Connor J.
Wang, Peng
Huang, Bin
Cheng, Simon K.
Deutsch, Israel
Gentry, Matthew S.
Sun, Ramon C.
author_sort Zhou, Zhengqiu
collection PubMed
description Clear cell adenocarcinoma (CCA) is a rare variant of urinary bladder carcinoma with a glycogen-rich phenotype and unknown prognosis. Using the National Cancer Institute’s surveillance, epidemiology, and end results (SEER) program database, we documented recent trends in incidence, mortality, demographical characteristics, and survival on this rare subtype of urinary bladder cancer. The overall age-adjusted incidence and mortality of CCA was 0.087 (95% confidence interval (CI): 0.069–0.107) and 0.064 (95% CI: 0.049–0.081) respectively per million population. In comparison to non-CCAs, CCAs were more commonly associated with younger age (<60 years old, p = 0.005), female (p < 0.001), black ethnicity (p = 0.001), grade III (p < 0.001), and higher AJCC 6th staging (p < 0.001). In addition, CCA patients more frequently received complete cystectomy (p < 0.001) and beam radiation (p < 0.001) than non-CCA patients. Our study showed a poorer prognosis of CCAs compared to all other carcinomas of the urinary bladder (p < 0.001), accounted for by higher tumor staging of CCA cases. This study adds to the growing evidence that glycogen-rich cancers may have unique characteristics affecting tumor aggressiveness and patient prognosis. Additional mechanistic studies are needed to assess whether it’s the excess glycogen that contributes to the higher stage at diagnosis.
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spelling pubmed-70195662020-03-09 Clear Cell Adenocarcinoma of the Urinary Bladder Is a Glycogen-Rich Tumor with Poorer Prognosis Zhou, Zhengqiu Kinslow, Connor J. Wang, Peng Huang, Bin Cheng, Simon K. Deutsch, Israel Gentry, Matthew S. Sun, Ramon C. J Clin Med Article Clear cell adenocarcinoma (CCA) is a rare variant of urinary bladder carcinoma with a glycogen-rich phenotype and unknown prognosis. Using the National Cancer Institute’s surveillance, epidemiology, and end results (SEER) program database, we documented recent trends in incidence, mortality, demographical characteristics, and survival on this rare subtype of urinary bladder cancer. The overall age-adjusted incidence and mortality of CCA was 0.087 (95% confidence interval (CI): 0.069–0.107) and 0.064 (95% CI: 0.049–0.081) respectively per million population. In comparison to non-CCAs, CCAs were more commonly associated with younger age (<60 years old, p = 0.005), female (p < 0.001), black ethnicity (p = 0.001), grade III (p < 0.001), and higher AJCC 6th staging (p < 0.001). In addition, CCA patients more frequently received complete cystectomy (p < 0.001) and beam radiation (p < 0.001) than non-CCA patients. Our study showed a poorer prognosis of CCAs compared to all other carcinomas of the urinary bladder (p < 0.001), accounted for by higher tumor staging of CCA cases. This study adds to the growing evidence that glycogen-rich cancers may have unique characteristics affecting tumor aggressiveness and patient prognosis. Additional mechanistic studies are needed to assess whether it’s the excess glycogen that contributes to the higher stage at diagnosis. MDPI 2020-01-03 /pmc/articles/PMC7019566/ /pubmed/31947882 http://dx.doi.org/10.3390/jcm9010138 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhou, Zhengqiu
Kinslow, Connor J.
Wang, Peng
Huang, Bin
Cheng, Simon K.
Deutsch, Israel
Gentry, Matthew S.
Sun, Ramon C.
Clear Cell Adenocarcinoma of the Urinary Bladder Is a Glycogen-Rich Tumor with Poorer Prognosis
title Clear Cell Adenocarcinoma of the Urinary Bladder Is a Glycogen-Rich Tumor with Poorer Prognosis
title_full Clear Cell Adenocarcinoma of the Urinary Bladder Is a Glycogen-Rich Tumor with Poorer Prognosis
title_fullStr Clear Cell Adenocarcinoma of the Urinary Bladder Is a Glycogen-Rich Tumor with Poorer Prognosis
title_full_unstemmed Clear Cell Adenocarcinoma of the Urinary Bladder Is a Glycogen-Rich Tumor with Poorer Prognosis
title_short Clear Cell Adenocarcinoma of the Urinary Bladder Is a Glycogen-Rich Tumor with Poorer Prognosis
title_sort clear cell adenocarcinoma of the urinary bladder is a glycogen-rich tumor with poorer prognosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019566/
https://www.ncbi.nlm.nih.gov/pubmed/31947882
http://dx.doi.org/10.3390/jcm9010138
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