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Usefulness of Clinical Definitions of Influenza for Public Health Surveillance Purposes

This study investigated the performance of various case definitions and influenza symptoms in a primary healthcare sentinel surveillance system. A retrospective study of the clinical and epidemiological characteristics of the cases reported by a primary healthcare sentinel surveillance network for e...

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Autores principales: Domínguez, Àngela, Soldevila, Núria, Torner, Núria, Martínez, Ana, Godoy, Pere, Rius, Cristina, Jané, Mireia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019582/
https://www.ncbi.nlm.nih.gov/pubmed/31947696
http://dx.doi.org/10.3390/v12010095
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author Domínguez, Àngela
Soldevila, Núria
Torner, Núria
Martínez, Ana
Godoy, Pere
Rius, Cristina
Jané, Mireia
author_facet Domínguez, Àngela
Soldevila, Núria
Torner, Núria
Martínez, Ana
Godoy, Pere
Rius, Cristina
Jané, Mireia
author_sort Domínguez, Àngela
collection PubMed
description This study investigated the performance of various case definitions and influenza symptoms in a primary healthcare sentinel surveillance system. A retrospective study of the clinical and epidemiological characteristics of the cases reported by a primary healthcare sentinel surveillance network for eleven years in Catalonia was conducted. Crude and adjusted diagnostic odds ratios (aDORs) and 95% confidence intervals (CIs) of the case definitions and symptoms for all weeks and epidemic weeks were estimated. The most predictive case definition for laboratory-confirmed influenza was the World Health Organization (WHO) case definition for ILI in all weeks (aDOR 2.69; 95% CI 2.42–2.99) and epidemic weeks (aDOR 2.20; 95% CI 1.90–2.54). The symptoms that were significant positive predictors for confirmed influenza were fever, cough, myalgia, headache, malaise, and sudden onset. Fever had the highest aDOR in all weeks (4.03; 95% CI 3.38–4.80) and epidemic weeks (2.78; 95% CI 2.21–3.50). All of the case definitions assessed performed better in patients with comorbidities than in those without. The performance of symptoms varied by age groups, with fever being of high value in older people, and cough being of high value in children. In patients with comorbidities, the performance of fever was the highest (aDOR 5.45; 95% CI 3.43–8.66). No differences in the performance of the case definition or symptoms in influenza cases according to virus type were found.
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spelling pubmed-70195822020-03-09 Usefulness of Clinical Definitions of Influenza for Public Health Surveillance Purposes Domínguez, Àngela Soldevila, Núria Torner, Núria Martínez, Ana Godoy, Pere Rius, Cristina Jané, Mireia Viruses Article This study investigated the performance of various case definitions and influenza symptoms in a primary healthcare sentinel surveillance system. A retrospective study of the clinical and epidemiological characteristics of the cases reported by a primary healthcare sentinel surveillance network for eleven years in Catalonia was conducted. Crude and adjusted diagnostic odds ratios (aDORs) and 95% confidence intervals (CIs) of the case definitions and symptoms for all weeks and epidemic weeks were estimated. The most predictive case definition for laboratory-confirmed influenza was the World Health Organization (WHO) case definition for ILI in all weeks (aDOR 2.69; 95% CI 2.42–2.99) and epidemic weeks (aDOR 2.20; 95% CI 1.90–2.54). The symptoms that were significant positive predictors for confirmed influenza were fever, cough, myalgia, headache, malaise, and sudden onset. Fever had the highest aDOR in all weeks (4.03; 95% CI 3.38–4.80) and epidemic weeks (2.78; 95% CI 2.21–3.50). All of the case definitions assessed performed better in patients with comorbidities than in those without. The performance of symptoms varied by age groups, with fever being of high value in older people, and cough being of high value in children. In patients with comorbidities, the performance of fever was the highest (aDOR 5.45; 95% CI 3.43–8.66). No differences in the performance of the case definition or symptoms in influenza cases according to virus type were found. MDPI 2020-01-14 /pmc/articles/PMC7019582/ /pubmed/31947696 http://dx.doi.org/10.3390/v12010095 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Domínguez, Àngela
Soldevila, Núria
Torner, Núria
Martínez, Ana
Godoy, Pere
Rius, Cristina
Jané, Mireia
Usefulness of Clinical Definitions of Influenza for Public Health Surveillance Purposes
title Usefulness of Clinical Definitions of Influenza for Public Health Surveillance Purposes
title_full Usefulness of Clinical Definitions of Influenza for Public Health Surveillance Purposes
title_fullStr Usefulness of Clinical Definitions of Influenza for Public Health Surveillance Purposes
title_full_unstemmed Usefulness of Clinical Definitions of Influenza for Public Health Surveillance Purposes
title_short Usefulness of Clinical Definitions of Influenza for Public Health Surveillance Purposes
title_sort usefulness of clinical definitions of influenza for public health surveillance purposes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019582/
https://www.ncbi.nlm.nih.gov/pubmed/31947696
http://dx.doi.org/10.3390/v12010095
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