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Efficacy of Isomaltulose Compared to Sucrose in Modulating Endothelial Function in Overweight Adults

Hyperglycemia is linked to impaired arterial endothelial function (EF), an early sign of cardiovascular disease. We compared the efficacy of low-glycemic index isomaltulose (Palatinose™) with that of sucrose in modulating EF, as assessed by flow-mediated dilation (FMD). In this double-blinded cross-...

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Autores principales: de Groot, Eric, Schweitzer, Lisa, Theis, Stephan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019610/
https://www.ncbi.nlm.nih.gov/pubmed/31947853
http://dx.doi.org/10.3390/nu12010141
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author de Groot, Eric
Schweitzer, Lisa
Theis, Stephan
author_facet de Groot, Eric
Schweitzer, Lisa
Theis, Stephan
author_sort de Groot, Eric
collection PubMed
description Hyperglycemia is linked to impaired arterial endothelial function (EF), an early sign of cardiovascular disease. We compared the efficacy of low-glycemic index isomaltulose (Palatinose™) with that of sucrose in modulating EF, as assessed by flow-mediated dilation (FMD). In this double-blinded cross-over study, 80 overweight mildly hypertensive subjects were randomized to receive 50 g of either isomaltulose or sucrose. On two non-consecutive days, brachial artery ultrasound FMD scans were obtained prior to and hourly (T0–T3) after carbohydrate load. Blood was drawn immediately after scanning. Glucose and insulin levels were analyzed. Overall, the FMD decrease was attenuated by isomaltulose compared to sucrose (ΔFMD = −0.003% and −0.151%; p > 0.05 for the interaction treatment x period). At T2, FMD was significantly higher after isomaltulose administration compared to that after sucrose administration (FMD = 5.9 ± 2.9% and 5.4 ± 2.6%, p = 0.047). Pearson correlations between FMD and blood glucose showed a trend for a negative association at T0 and T2 independently of the carbohydrate (r-range = −0.20 to −0.23, p < 0.1). Sub-analysis suggested a lower FMD in insulin-resistant (IR) compared to insulin-sensitive subjects. Isomaltulose attenuated the postprandial decline of FMD, particularly in IR persons. These data support the potential of isomaltulose to preserve the endothelial function postprandially and consequently play a favorable role in cardiovascular health.
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spelling pubmed-70196102020-03-09 Efficacy of Isomaltulose Compared to Sucrose in Modulating Endothelial Function in Overweight Adults de Groot, Eric Schweitzer, Lisa Theis, Stephan Nutrients Article Hyperglycemia is linked to impaired arterial endothelial function (EF), an early sign of cardiovascular disease. We compared the efficacy of low-glycemic index isomaltulose (Palatinose™) with that of sucrose in modulating EF, as assessed by flow-mediated dilation (FMD). In this double-blinded cross-over study, 80 overweight mildly hypertensive subjects were randomized to receive 50 g of either isomaltulose or sucrose. On two non-consecutive days, brachial artery ultrasound FMD scans were obtained prior to and hourly (T0–T3) after carbohydrate load. Blood was drawn immediately after scanning. Glucose and insulin levels were analyzed. Overall, the FMD decrease was attenuated by isomaltulose compared to sucrose (ΔFMD = −0.003% and −0.151%; p > 0.05 for the interaction treatment x period). At T2, FMD was significantly higher after isomaltulose administration compared to that after sucrose administration (FMD = 5.9 ± 2.9% and 5.4 ± 2.6%, p = 0.047). Pearson correlations between FMD and blood glucose showed a trend for a negative association at T0 and T2 independently of the carbohydrate (r-range = −0.20 to −0.23, p < 0.1). Sub-analysis suggested a lower FMD in insulin-resistant (IR) compared to insulin-sensitive subjects. Isomaltulose attenuated the postprandial decline of FMD, particularly in IR persons. These data support the potential of isomaltulose to preserve the endothelial function postprandially and consequently play a favorable role in cardiovascular health. MDPI 2020-01-03 /pmc/articles/PMC7019610/ /pubmed/31947853 http://dx.doi.org/10.3390/nu12010141 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
de Groot, Eric
Schweitzer, Lisa
Theis, Stephan
Efficacy of Isomaltulose Compared to Sucrose in Modulating Endothelial Function in Overweight Adults
title Efficacy of Isomaltulose Compared to Sucrose in Modulating Endothelial Function in Overweight Adults
title_full Efficacy of Isomaltulose Compared to Sucrose in Modulating Endothelial Function in Overweight Adults
title_fullStr Efficacy of Isomaltulose Compared to Sucrose in Modulating Endothelial Function in Overweight Adults
title_full_unstemmed Efficacy of Isomaltulose Compared to Sucrose in Modulating Endothelial Function in Overweight Adults
title_short Efficacy of Isomaltulose Compared to Sucrose in Modulating Endothelial Function in Overweight Adults
title_sort efficacy of isomaltulose compared to sucrose in modulating endothelial function in overweight adults
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019610/
https://www.ncbi.nlm.nih.gov/pubmed/31947853
http://dx.doi.org/10.3390/nu12010141
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