Cargando…

Minor Glomerular Abnormalities are Associated with Deterioration of Long-Term Kidney Function and Mitochondrial Injury

Minor glomerular abnormalities (MGAs) are unclassified glomerular lesions indicated by the presence of minor structural abnormalities that are insufficient for a specific pathological diagnosis. The long-term clinical outcomes and pathogenesis have not been examined. We hypothesized that MGAs would...

Descripción completa

Detalles Bibliográficos
Autores principales: Yu, Byung Chul, Cho, Nam-Jun, Park, Samel, Kim, Hyoungnae, Gil, Hyo-Wook, Lee, Eun Young, Kwon, Soon Hyo, Jeon, Jin Seok, Noh, Hyunjin, Han, Dong Cheol, Moon, Ahrim, Park, Su Jung, Kim, Jin Kuk, Hwang, Seung Duk, Choi, Soo Jeong, Park, Moo Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019622/
https://www.ncbi.nlm.nih.gov/pubmed/31877839
http://dx.doi.org/10.3390/jcm9010033
_version_ 1783497562248970240
author Yu, Byung Chul
Cho, Nam-Jun
Park, Samel
Kim, Hyoungnae
Gil, Hyo-Wook
Lee, Eun Young
Kwon, Soon Hyo
Jeon, Jin Seok
Noh, Hyunjin
Han, Dong Cheol
Moon, Ahrim
Park, Su Jung
Kim, Jin Kuk
Hwang, Seung Duk
Choi, Soo Jeong
Park, Moo Yong
author_facet Yu, Byung Chul
Cho, Nam-Jun
Park, Samel
Kim, Hyoungnae
Gil, Hyo-Wook
Lee, Eun Young
Kwon, Soon Hyo
Jeon, Jin Seok
Noh, Hyunjin
Han, Dong Cheol
Moon, Ahrim
Park, Su Jung
Kim, Jin Kuk
Hwang, Seung Duk
Choi, Soo Jeong
Park, Moo Yong
author_sort Yu, Byung Chul
collection PubMed
description Minor glomerular abnormalities (MGAs) are unclassified glomerular lesions indicated by the presence of minor structural abnormalities that are insufficient for a specific pathological diagnosis. The long-term clinical outcomes and pathogenesis have not been examined. We hypothesized that MGAs would be associated with the deterioration of long-term kidney function and increased urinary mitochondrial DNA (mtDNA) copy numbers. We retrospectively enrolled patients with MGAs, age-/sex-/estimated glomerular filtration rate (eGFR)-matched patients with immunoglobulin A nephropathy (IgAN), and similarly matched healthy controls (MHCs; n = 49 each). We analyzed the time × group interaction effects of the eGFR and compared mean annual eGFR decline rates between the groups. We prospectively enrolled patients with MGAs, age- and sex-matched patients with IgAN, and MHCs (n = 15 each) and compared their urinary mtDNA copy numbers. Compared to the MHC group, the MGA and IgAN groups displayed differences in the time × group effects of eGFR, higher mean annual rates of eGFR decline, and higher urinary mtDNA copy numbers; however, these groups did not significantly differ from each other. The results indicate that MGAs are associated with deteriorating long-term kidney function, and mitochondrial injury, despite few additional pathological changes. We suggest that clinicians conduct close long-term follow-up of patients with MGAs.
format Online
Article
Text
id pubmed-7019622
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-70196222020-03-09 Minor Glomerular Abnormalities are Associated with Deterioration of Long-Term Kidney Function and Mitochondrial Injury Yu, Byung Chul Cho, Nam-Jun Park, Samel Kim, Hyoungnae Gil, Hyo-Wook Lee, Eun Young Kwon, Soon Hyo Jeon, Jin Seok Noh, Hyunjin Han, Dong Cheol Moon, Ahrim Park, Su Jung Kim, Jin Kuk Hwang, Seung Duk Choi, Soo Jeong Park, Moo Yong J Clin Med Article Minor glomerular abnormalities (MGAs) are unclassified glomerular lesions indicated by the presence of minor structural abnormalities that are insufficient for a specific pathological diagnosis. The long-term clinical outcomes and pathogenesis have not been examined. We hypothesized that MGAs would be associated with the deterioration of long-term kidney function and increased urinary mitochondrial DNA (mtDNA) copy numbers. We retrospectively enrolled patients with MGAs, age-/sex-/estimated glomerular filtration rate (eGFR)-matched patients with immunoglobulin A nephropathy (IgAN), and similarly matched healthy controls (MHCs; n = 49 each). We analyzed the time × group interaction effects of the eGFR and compared mean annual eGFR decline rates between the groups. We prospectively enrolled patients with MGAs, age- and sex-matched patients with IgAN, and MHCs (n = 15 each) and compared their urinary mtDNA copy numbers. Compared to the MHC group, the MGA and IgAN groups displayed differences in the time × group effects of eGFR, higher mean annual rates of eGFR decline, and higher urinary mtDNA copy numbers; however, these groups did not significantly differ from each other. The results indicate that MGAs are associated with deteriorating long-term kidney function, and mitochondrial injury, despite few additional pathological changes. We suggest that clinicians conduct close long-term follow-up of patients with MGAs. MDPI 2019-12-22 /pmc/articles/PMC7019622/ /pubmed/31877839 http://dx.doi.org/10.3390/jcm9010033 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yu, Byung Chul
Cho, Nam-Jun
Park, Samel
Kim, Hyoungnae
Gil, Hyo-Wook
Lee, Eun Young
Kwon, Soon Hyo
Jeon, Jin Seok
Noh, Hyunjin
Han, Dong Cheol
Moon, Ahrim
Park, Su Jung
Kim, Jin Kuk
Hwang, Seung Duk
Choi, Soo Jeong
Park, Moo Yong
Minor Glomerular Abnormalities are Associated with Deterioration of Long-Term Kidney Function and Mitochondrial Injury
title Minor Glomerular Abnormalities are Associated with Deterioration of Long-Term Kidney Function and Mitochondrial Injury
title_full Minor Glomerular Abnormalities are Associated with Deterioration of Long-Term Kidney Function and Mitochondrial Injury
title_fullStr Minor Glomerular Abnormalities are Associated with Deterioration of Long-Term Kidney Function and Mitochondrial Injury
title_full_unstemmed Minor Glomerular Abnormalities are Associated with Deterioration of Long-Term Kidney Function and Mitochondrial Injury
title_short Minor Glomerular Abnormalities are Associated with Deterioration of Long-Term Kidney Function and Mitochondrial Injury
title_sort minor glomerular abnormalities are associated with deterioration of long-term kidney function and mitochondrial injury
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019622/
https://www.ncbi.nlm.nih.gov/pubmed/31877839
http://dx.doi.org/10.3390/jcm9010033
work_keys_str_mv AT yubyungchul minorglomerularabnormalitiesareassociatedwithdeteriorationoflongtermkidneyfunctionandmitochondrialinjury
AT chonamjun minorglomerularabnormalitiesareassociatedwithdeteriorationoflongtermkidneyfunctionandmitochondrialinjury
AT parksamel minorglomerularabnormalitiesareassociatedwithdeteriorationoflongtermkidneyfunctionandmitochondrialinjury
AT kimhyoungnae minorglomerularabnormalitiesareassociatedwithdeteriorationoflongtermkidneyfunctionandmitochondrialinjury
AT gilhyowook minorglomerularabnormalitiesareassociatedwithdeteriorationoflongtermkidneyfunctionandmitochondrialinjury
AT leeeunyoung minorglomerularabnormalitiesareassociatedwithdeteriorationoflongtermkidneyfunctionandmitochondrialinjury
AT kwonsoonhyo minorglomerularabnormalitiesareassociatedwithdeteriorationoflongtermkidneyfunctionandmitochondrialinjury
AT jeonjinseok minorglomerularabnormalitiesareassociatedwithdeteriorationoflongtermkidneyfunctionandmitochondrialinjury
AT nohhyunjin minorglomerularabnormalitiesareassociatedwithdeteriorationoflongtermkidneyfunctionandmitochondrialinjury
AT handongcheol minorglomerularabnormalitiesareassociatedwithdeteriorationoflongtermkidneyfunctionandmitochondrialinjury
AT moonahrim minorglomerularabnormalitiesareassociatedwithdeteriorationoflongtermkidneyfunctionandmitochondrialinjury
AT parksujung minorglomerularabnormalitiesareassociatedwithdeteriorationoflongtermkidneyfunctionandmitochondrialinjury
AT kimjinkuk minorglomerularabnormalitiesareassociatedwithdeteriorationoflongtermkidneyfunctionandmitochondrialinjury
AT hwangseungduk minorglomerularabnormalitiesareassociatedwithdeteriorationoflongtermkidneyfunctionandmitochondrialinjury
AT choisoojeong minorglomerularabnormalitiesareassociatedwithdeteriorationoflongtermkidneyfunctionandmitochondrialinjury
AT parkmooyong minorglomerularabnormalitiesareassociatedwithdeteriorationoflongtermkidneyfunctionandmitochondrialinjury