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Identification of a Circulating Amino Acid Signature in Frail Older Persons with Type 2 Diabetes Mellitus: Results from the Metabofrail Study

Diabetes and frailty are highly prevalent conditions that impact the health status of older adults. Perturbations in protein/amino acid metabolism are associated with both functional impairment and type 2 diabetes mellitus (T2DM). In the present study, we compared the concentrations of a panel of ci...

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Autores principales: Calvani, Riccardo, Rodriguez-Mañas, Leocadio, Picca, Anna, Marini, Federico, Biancolillo, Alessandra, Laosa, Olga, Pedraza, Laura, Gervasoni, Jacopo, Primiano, Aniello, Conta, Giorgia, Bourdel-Marchasson, Isabelle, Regueme, Sophie C., Bernabei, Roberto, Marzetti, Emanuele, Sinclair, Alan J., Gambassi, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019630/
https://www.ncbi.nlm.nih.gov/pubmed/31940925
http://dx.doi.org/10.3390/nu12010199
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author Calvani, Riccardo
Rodriguez-Mañas, Leocadio
Picca, Anna
Marini, Federico
Biancolillo, Alessandra
Laosa, Olga
Pedraza, Laura
Gervasoni, Jacopo
Primiano, Aniello
Conta, Giorgia
Bourdel-Marchasson, Isabelle
Regueme, Sophie C.
Bernabei, Roberto
Marzetti, Emanuele
Sinclair, Alan J.
Gambassi, Giovanni
author_facet Calvani, Riccardo
Rodriguez-Mañas, Leocadio
Picca, Anna
Marini, Federico
Biancolillo, Alessandra
Laosa, Olga
Pedraza, Laura
Gervasoni, Jacopo
Primiano, Aniello
Conta, Giorgia
Bourdel-Marchasson, Isabelle
Regueme, Sophie C.
Bernabei, Roberto
Marzetti, Emanuele
Sinclair, Alan J.
Gambassi, Giovanni
author_sort Calvani, Riccardo
collection PubMed
description Diabetes and frailty are highly prevalent conditions that impact the health status of older adults. Perturbations in protein/amino acid metabolism are associated with both functional impairment and type 2 diabetes mellitus (T2DM). In the present study, we compared the concentrations of a panel of circulating 37 amino acids and derivatives between frail/pre-frail older adults with T2DM and robust non-diabetic controls. Sixty-six functionally impaired older persons aged 70+ with T2DM and 30 age and sex-matched controls were included in the analysis. We applied a partial least squares-discriminant analysis (PLS-DA)-based analytical strategy to characterize the metabotype of study participants. The optimal complexity of the PLS-DA model was found to be two latent variables. The proportion of correct classification was 94.1 ± 1.9% for frail/pre-frail persons with T2DM and 100% for control participants. Functionally impaired older persons with T2DM showed higher levels of 3-methyl histidine, alanine, arginine, glutamic acid, ethanolamine sarcosine, and tryptophan. Control participants had higher levels of ornithine and taurine. These findings indicate that a specific profile of amino acids and derivatives characterizes pre-frail/frail older persons with T2DM. The dissection of these pathways may provide novel insights into the metabolic perturbations involved in the disabling cascade in older persons with T2DM.
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spelling pubmed-70196302020-03-09 Identification of a Circulating Amino Acid Signature in Frail Older Persons with Type 2 Diabetes Mellitus: Results from the Metabofrail Study Calvani, Riccardo Rodriguez-Mañas, Leocadio Picca, Anna Marini, Federico Biancolillo, Alessandra Laosa, Olga Pedraza, Laura Gervasoni, Jacopo Primiano, Aniello Conta, Giorgia Bourdel-Marchasson, Isabelle Regueme, Sophie C. Bernabei, Roberto Marzetti, Emanuele Sinclair, Alan J. Gambassi, Giovanni Nutrients Article Diabetes and frailty are highly prevalent conditions that impact the health status of older adults. Perturbations in protein/amino acid metabolism are associated with both functional impairment and type 2 diabetes mellitus (T2DM). In the present study, we compared the concentrations of a panel of circulating 37 amino acids and derivatives between frail/pre-frail older adults with T2DM and robust non-diabetic controls. Sixty-six functionally impaired older persons aged 70+ with T2DM and 30 age and sex-matched controls were included in the analysis. We applied a partial least squares-discriminant analysis (PLS-DA)-based analytical strategy to characterize the metabotype of study participants. The optimal complexity of the PLS-DA model was found to be two latent variables. The proportion of correct classification was 94.1 ± 1.9% for frail/pre-frail persons with T2DM and 100% for control participants. Functionally impaired older persons with T2DM showed higher levels of 3-methyl histidine, alanine, arginine, glutamic acid, ethanolamine sarcosine, and tryptophan. Control participants had higher levels of ornithine and taurine. These findings indicate that a specific profile of amino acids and derivatives characterizes pre-frail/frail older persons with T2DM. The dissection of these pathways may provide novel insights into the metabolic perturbations involved in the disabling cascade in older persons with T2DM. MDPI 2020-01-12 /pmc/articles/PMC7019630/ /pubmed/31940925 http://dx.doi.org/10.3390/nu12010199 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Calvani, Riccardo
Rodriguez-Mañas, Leocadio
Picca, Anna
Marini, Federico
Biancolillo, Alessandra
Laosa, Olga
Pedraza, Laura
Gervasoni, Jacopo
Primiano, Aniello
Conta, Giorgia
Bourdel-Marchasson, Isabelle
Regueme, Sophie C.
Bernabei, Roberto
Marzetti, Emanuele
Sinclair, Alan J.
Gambassi, Giovanni
Identification of a Circulating Amino Acid Signature in Frail Older Persons with Type 2 Diabetes Mellitus: Results from the Metabofrail Study
title Identification of a Circulating Amino Acid Signature in Frail Older Persons with Type 2 Diabetes Mellitus: Results from the Metabofrail Study
title_full Identification of a Circulating Amino Acid Signature in Frail Older Persons with Type 2 Diabetes Mellitus: Results from the Metabofrail Study
title_fullStr Identification of a Circulating Amino Acid Signature in Frail Older Persons with Type 2 Diabetes Mellitus: Results from the Metabofrail Study
title_full_unstemmed Identification of a Circulating Amino Acid Signature in Frail Older Persons with Type 2 Diabetes Mellitus: Results from the Metabofrail Study
title_short Identification of a Circulating Amino Acid Signature in Frail Older Persons with Type 2 Diabetes Mellitus: Results from the Metabofrail Study
title_sort identification of a circulating amino acid signature in frail older persons with type 2 diabetes mellitus: results from the metabofrail study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019630/
https://www.ncbi.nlm.nih.gov/pubmed/31940925
http://dx.doi.org/10.3390/nu12010199
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