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Changes in Metabolic Syndrome Status and Risk of Dementia

This study investigated the effects of changes in metabolic syndrome (MS) status and each component on subsequent dementia occurrence. The study population was participants of a biennial National Health Screening Program in 2009–2010 and 2011–2012 in Korea. Participants were divided into four groups...

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Autores principales: Lee, Ji Eun, Shin, Dong Wook, Han, Kyungdo, Kim, Dahye, Yoo, Jung Eun, Lee, Jinkook, Kim, SangYun, Son, Ki Young, Cho, Belong, Kim, Moon Jong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019689/
https://www.ncbi.nlm.nih.gov/pubmed/31906539
http://dx.doi.org/10.3390/jcm9010122
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author Lee, Ji Eun
Shin, Dong Wook
Han, Kyungdo
Kim, Dahye
Yoo, Jung Eun
Lee, Jinkook
Kim, SangYun
Son, Ki Young
Cho, Belong
Kim, Moon Jong
author_facet Lee, Ji Eun
Shin, Dong Wook
Han, Kyungdo
Kim, Dahye
Yoo, Jung Eun
Lee, Jinkook
Kim, SangYun
Son, Ki Young
Cho, Belong
Kim, Moon Jong
author_sort Lee, Ji Eun
collection PubMed
description This study investigated the effects of changes in metabolic syndrome (MS) status and each component on subsequent dementia occurrence. The study population was participants of a biennial National Health Screening Program in 2009–2010 and 2011–2012 in Korea. Participants were divided into four groups according to change in MS status during the two-year interval screening: sustained normal, worsened (normal to MS), improved (MS to normal), and sustained MS group. Risk of dementia among the groups was estimated from the second screening date to 31 December 2016 using a Cox proportional hazards model. A total of 4,106,590 participants were included. The mean follow-up was 4.9 years. Compared to the sustained normal group, adjusted hazard ratios (aHR) (95% confidence interval) were 1.11 (1.08–1.13) for total dementia, 1.08 (1.05–1.11) for Alzheimer’s disease, and 1.20 (1.13–1.28) for vascular dementia in the worsened group; 1.12 (1.10–1.15), 1.10 (1.07–1.13), and 1.19 (1.12–1.27) for the improved group; and 1.18 (1.16–1.20), 1.13 (1.11–1.15), and 1.38 (1.32–1.44) for the sustained MS group. Normalization of MS lowered the risk of all dementia types; total dementia (aHR 1.18 versus 1.12), Alzheimer’s disease (1.13 versus 1.10), and vascular dementia (1.38 versus 1.19). Among MS components, fasting glucose and blood pressure showed more impact. In conclusion, changes in MS status were associated with the risk of dementia. Strategies to improve MS, especially hyperglycemia and blood pressure, may help to prevent dementia.
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spelling pubmed-70196892020-03-09 Changes in Metabolic Syndrome Status and Risk of Dementia Lee, Ji Eun Shin, Dong Wook Han, Kyungdo Kim, Dahye Yoo, Jung Eun Lee, Jinkook Kim, SangYun Son, Ki Young Cho, Belong Kim, Moon Jong J Clin Med Article This study investigated the effects of changes in metabolic syndrome (MS) status and each component on subsequent dementia occurrence. The study population was participants of a biennial National Health Screening Program in 2009–2010 and 2011–2012 in Korea. Participants were divided into four groups according to change in MS status during the two-year interval screening: sustained normal, worsened (normal to MS), improved (MS to normal), and sustained MS group. Risk of dementia among the groups was estimated from the second screening date to 31 December 2016 using a Cox proportional hazards model. A total of 4,106,590 participants were included. The mean follow-up was 4.9 years. Compared to the sustained normal group, adjusted hazard ratios (aHR) (95% confidence interval) were 1.11 (1.08–1.13) for total dementia, 1.08 (1.05–1.11) for Alzheimer’s disease, and 1.20 (1.13–1.28) for vascular dementia in the worsened group; 1.12 (1.10–1.15), 1.10 (1.07–1.13), and 1.19 (1.12–1.27) for the improved group; and 1.18 (1.16–1.20), 1.13 (1.11–1.15), and 1.38 (1.32–1.44) for the sustained MS group. Normalization of MS lowered the risk of all dementia types; total dementia (aHR 1.18 versus 1.12), Alzheimer’s disease (1.13 versus 1.10), and vascular dementia (1.38 versus 1.19). Among MS components, fasting glucose and blood pressure showed more impact. In conclusion, changes in MS status were associated with the risk of dementia. Strategies to improve MS, especially hyperglycemia and blood pressure, may help to prevent dementia. MDPI 2020-01-02 /pmc/articles/PMC7019689/ /pubmed/31906539 http://dx.doi.org/10.3390/jcm9010122 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lee, Ji Eun
Shin, Dong Wook
Han, Kyungdo
Kim, Dahye
Yoo, Jung Eun
Lee, Jinkook
Kim, SangYun
Son, Ki Young
Cho, Belong
Kim, Moon Jong
Changes in Metabolic Syndrome Status and Risk of Dementia
title Changes in Metabolic Syndrome Status and Risk of Dementia
title_full Changes in Metabolic Syndrome Status and Risk of Dementia
title_fullStr Changes in Metabolic Syndrome Status and Risk of Dementia
title_full_unstemmed Changes in Metabolic Syndrome Status and Risk of Dementia
title_short Changes in Metabolic Syndrome Status and Risk of Dementia
title_sort changes in metabolic syndrome status and risk of dementia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019689/
https://www.ncbi.nlm.nih.gov/pubmed/31906539
http://dx.doi.org/10.3390/jcm9010122
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