Cargando…

Diagnostic Performance of Cyclophilin A in Cardiac Surgery-Associated Acute Kidney Injury

Acute kidney injury (AKI) is associated with increased morbidity and mortality and is frequently encountered in cardiovascular surgical intensive care units (CVS-ICU). In this study, we aimed at investigating the utility of cyclophilin A (CypA) for the early detection of postoperative AKI in patient...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Cheng-Chia, Chang, Chih-Hsiang, Cheng, Ya-Lien, Kuo, George, Chen, Shao-Wei, Li, Yi-Jung, Chen, Yi-Ting, Tian, Ya-Chung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019745/
https://www.ncbi.nlm.nih.gov/pubmed/31906134
http://dx.doi.org/10.3390/jcm9010108
_version_ 1783497590372827136
author Lee, Cheng-Chia
Chang, Chih-Hsiang
Cheng, Ya-Lien
Kuo, George
Chen, Shao-Wei
Li, Yi-Jung
Chen, Yi-Ting
Tian, Ya-Chung
author_facet Lee, Cheng-Chia
Chang, Chih-Hsiang
Cheng, Ya-Lien
Kuo, George
Chen, Shao-Wei
Li, Yi-Jung
Chen, Yi-Ting
Tian, Ya-Chung
author_sort Lee, Cheng-Chia
collection PubMed
description Acute kidney injury (AKI) is associated with increased morbidity and mortality and is frequently encountered in cardiovascular surgical intensive care units (CVS-ICU). In this study, we aimed at investigating the utility of cyclophilin A (CypA) for the early detection of postoperative AKI in patients undergoing cardiac surgery. This was a prospective observational study conducted in a CVS-ICU of a tertiary care university hospital. All prospective clinical and laboratory data were evaluated as predictors of AKI. Serum and urine CypA, as well as urine neutrophil gelatinase-associated lipocalin (uNGAL), were examined within 6 h after cardiac surgery. The discriminative power for the prediction of AKI was evaluated using the area under the receiver operator characteristic curve (AUROC). We found that both serum CypA and urine CypA were significantly higher in the AKI group than in the non-AKI group. For discriminating AKI and dialysis-requiring AKI, serum CypA demonstrated acceptable AUROC values (0.689 and 0.738, respectively). The discrimination ability of urine CypA for predicting AKI was modest, but it was acceptable for predicting dialysis-requiring AKI (AUROC = 0.762). uNGAL best predicted the development of AKI, but its sensitivity was not good. A combination of serum CypA and uNGAL enhanced the overall performance for predicting the future development of AKI and dialysis-requiring AKI. Our results suggest that CypA is suitable as a biomarker for the early detection of postoperative AKI in CVS–ICU. However, it has better discriminating ability when combined with uNGAL for predicting AKI in CVS-ICU patients.
format Online
Article
Text
id pubmed-7019745
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-70197452020-03-09 Diagnostic Performance of Cyclophilin A in Cardiac Surgery-Associated Acute Kidney Injury Lee, Cheng-Chia Chang, Chih-Hsiang Cheng, Ya-Lien Kuo, George Chen, Shao-Wei Li, Yi-Jung Chen, Yi-Ting Tian, Ya-Chung J Clin Med Article Acute kidney injury (AKI) is associated with increased morbidity and mortality and is frequently encountered in cardiovascular surgical intensive care units (CVS-ICU). In this study, we aimed at investigating the utility of cyclophilin A (CypA) for the early detection of postoperative AKI in patients undergoing cardiac surgery. This was a prospective observational study conducted in a CVS-ICU of a tertiary care university hospital. All prospective clinical and laboratory data were evaluated as predictors of AKI. Serum and urine CypA, as well as urine neutrophil gelatinase-associated lipocalin (uNGAL), were examined within 6 h after cardiac surgery. The discriminative power for the prediction of AKI was evaluated using the area under the receiver operator characteristic curve (AUROC). We found that both serum CypA and urine CypA were significantly higher in the AKI group than in the non-AKI group. For discriminating AKI and dialysis-requiring AKI, serum CypA demonstrated acceptable AUROC values (0.689 and 0.738, respectively). The discrimination ability of urine CypA for predicting AKI was modest, but it was acceptable for predicting dialysis-requiring AKI (AUROC = 0.762). uNGAL best predicted the development of AKI, but its sensitivity was not good. A combination of serum CypA and uNGAL enhanced the overall performance for predicting the future development of AKI and dialysis-requiring AKI. Our results suggest that CypA is suitable as a biomarker for the early detection of postoperative AKI in CVS–ICU. However, it has better discriminating ability when combined with uNGAL for predicting AKI in CVS-ICU patients. MDPI 2019-12-31 /pmc/articles/PMC7019745/ /pubmed/31906134 http://dx.doi.org/10.3390/jcm9010108 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lee, Cheng-Chia
Chang, Chih-Hsiang
Cheng, Ya-Lien
Kuo, George
Chen, Shao-Wei
Li, Yi-Jung
Chen, Yi-Ting
Tian, Ya-Chung
Diagnostic Performance of Cyclophilin A in Cardiac Surgery-Associated Acute Kidney Injury
title Diagnostic Performance of Cyclophilin A in Cardiac Surgery-Associated Acute Kidney Injury
title_full Diagnostic Performance of Cyclophilin A in Cardiac Surgery-Associated Acute Kidney Injury
title_fullStr Diagnostic Performance of Cyclophilin A in Cardiac Surgery-Associated Acute Kidney Injury
title_full_unstemmed Diagnostic Performance of Cyclophilin A in Cardiac Surgery-Associated Acute Kidney Injury
title_short Diagnostic Performance of Cyclophilin A in Cardiac Surgery-Associated Acute Kidney Injury
title_sort diagnostic performance of cyclophilin a in cardiac surgery-associated acute kidney injury
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019745/
https://www.ncbi.nlm.nih.gov/pubmed/31906134
http://dx.doi.org/10.3390/jcm9010108
work_keys_str_mv AT leechengchia diagnosticperformanceofcyclophilinaincardiacsurgeryassociatedacutekidneyinjury
AT changchihhsiang diagnosticperformanceofcyclophilinaincardiacsurgeryassociatedacutekidneyinjury
AT chengyalien diagnosticperformanceofcyclophilinaincardiacsurgeryassociatedacutekidneyinjury
AT kuogeorge diagnosticperformanceofcyclophilinaincardiacsurgeryassociatedacutekidneyinjury
AT chenshaowei diagnosticperformanceofcyclophilinaincardiacsurgeryassociatedacutekidneyinjury
AT liyijung diagnosticperformanceofcyclophilinaincardiacsurgeryassociatedacutekidneyinjury
AT chenyiting diagnosticperformanceofcyclophilinaincardiacsurgeryassociatedacutekidneyinjury
AT tianyachung diagnosticperformanceofcyclophilinaincardiacsurgeryassociatedacutekidneyinjury