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Selenium Supplementation and Prostate Health in a New Zealand Cohort

Background: There is variable reporting on the benefits of a 200 μg/d selenium supplementation towards reducing prostate cancer impacts. The current analysis is to understand whether stratified groups receive supplementation benefits on prostate health. Methods: 572 men were supplemented with 200 µg...

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Autores principales: Karunasinghe, Nishi, Ng, Lance, Wang, Alice, Vaidyanathan, Venkatesh, Zhu, Shuotun, Ferguson, Lynnette R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019779/
https://www.ncbi.nlm.nih.gov/pubmed/31861307
http://dx.doi.org/10.3390/nu12010002
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author Karunasinghe, Nishi
Ng, Lance
Wang, Alice
Vaidyanathan, Venkatesh
Zhu, Shuotun
Ferguson, Lynnette R.
author_facet Karunasinghe, Nishi
Ng, Lance
Wang, Alice
Vaidyanathan, Venkatesh
Zhu, Shuotun
Ferguson, Lynnette R.
author_sort Karunasinghe, Nishi
collection PubMed
description Background: There is variable reporting on the benefits of a 200 μg/d selenium supplementation towards reducing prostate cancer impacts. The current analysis is to understand whether stratified groups receive supplementation benefits on prostate health. Methods: 572 men were supplemented with 200 µg/d selenium as selinized yeast for six months, and 481 completed the protocol. Selenium and prostate-specific antigen (PSA) levels were measured in serum at pre- and post-supplementation. Changes in selenium and PSA levels subsequent to supplementation were assessed with and without demographic, lifestyle, genetic and dietary stratifications. Results: The post-supplementation selenium (p = 0.002) and the gain in selenium (p < 0.0001) by supplementation were significantly dependent on the baseline selenium level. Overall, there was no significant correlation between changes in PSA and changes in selenium levels by supplementation. However, stratified analyses showed a significant inverse correlation between changes in PSA and changes in selenium in men below the median age (p = 0.048), never-smokers (p = 0.031), men carrying the GPX1 rs1050450 T allele (CT, p = 0.022 and TT, p = 0.011), dietary intakes above the recommended daily intake (RDI) for zinc (p < 0.05), and below the RDI for vitamin B12 (p < 0.001). Conclusions: The current analysis shows the influence of life factors on prostate health benefits of supplemental selenium.
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spelling pubmed-70197792020-03-09 Selenium Supplementation and Prostate Health in a New Zealand Cohort Karunasinghe, Nishi Ng, Lance Wang, Alice Vaidyanathan, Venkatesh Zhu, Shuotun Ferguson, Lynnette R. Nutrients Article Background: There is variable reporting on the benefits of a 200 μg/d selenium supplementation towards reducing prostate cancer impacts. The current analysis is to understand whether stratified groups receive supplementation benefits on prostate health. Methods: 572 men were supplemented with 200 µg/d selenium as selinized yeast for six months, and 481 completed the protocol. Selenium and prostate-specific antigen (PSA) levels were measured in serum at pre- and post-supplementation. Changes in selenium and PSA levels subsequent to supplementation were assessed with and without demographic, lifestyle, genetic and dietary stratifications. Results: The post-supplementation selenium (p = 0.002) and the gain in selenium (p < 0.0001) by supplementation were significantly dependent on the baseline selenium level. Overall, there was no significant correlation between changes in PSA and changes in selenium levels by supplementation. However, stratified analyses showed a significant inverse correlation between changes in PSA and changes in selenium in men below the median age (p = 0.048), never-smokers (p = 0.031), men carrying the GPX1 rs1050450 T allele (CT, p = 0.022 and TT, p = 0.011), dietary intakes above the recommended daily intake (RDI) for zinc (p < 0.05), and below the RDI for vitamin B12 (p < 0.001). Conclusions: The current analysis shows the influence of life factors on prostate health benefits of supplemental selenium. MDPI 2019-12-18 /pmc/articles/PMC7019779/ /pubmed/31861307 http://dx.doi.org/10.3390/nu12010002 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Karunasinghe, Nishi
Ng, Lance
Wang, Alice
Vaidyanathan, Venkatesh
Zhu, Shuotun
Ferguson, Lynnette R.
Selenium Supplementation and Prostate Health in a New Zealand Cohort
title Selenium Supplementation and Prostate Health in a New Zealand Cohort
title_full Selenium Supplementation and Prostate Health in a New Zealand Cohort
title_fullStr Selenium Supplementation and Prostate Health in a New Zealand Cohort
title_full_unstemmed Selenium Supplementation and Prostate Health in a New Zealand Cohort
title_short Selenium Supplementation and Prostate Health in a New Zealand Cohort
title_sort selenium supplementation and prostate health in a new zealand cohort
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019779/
https://www.ncbi.nlm.nih.gov/pubmed/31861307
http://dx.doi.org/10.3390/nu12010002
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