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IgG Anti-High Density Lipoprotein Antibodies Are Elevated in Abdominal Aortic Aneurysm and Associated with Lipid Profile and Clinical Features

High-density lipoproteins cholesterol (HDLc) levels are decreased in abdominal aortic aneurysm (AAA), which is hallmarked by autoimmunity and lipid aortic deposits. To investigate whether IgG anti-HDL antibodies were present in AAA and their potential association with clinical features, IgG anti-HDL...

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Autores principales: Rodríguez-Carrio, Javier, Lindholt, Jes S., Canyelles, Marina, Martínez-López, Diego, Tondo, Mireia, Blanco-Colio, Luis M., Michel, Jean-Baptiste, Escolà-Gil, Joan Carles, Suárez, Ana, Martín-Ventura, José Luis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019833/
https://www.ncbi.nlm.nih.gov/pubmed/31888089
http://dx.doi.org/10.3390/jcm9010067
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author Rodríguez-Carrio, Javier
Lindholt, Jes S.
Canyelles, Marina
Martínez-López, Diego
Tondo, Mireia
Blanco-Colio, Luis M.
Michel, Jean-Baptiste
Escolà-Gil, Joan Carles
Suárez, Ana
Martín-Ventura, José Luis
author_facet Rodríguez-Carrio, Javier
Lindholt, Jes S.
Canyelles, Marina
Martínez-López, Diego
Tondo, Mireia
Blanco-Colio, Luis M.
Michel, Jean-Baptiste
Escolà-Gil, Joan Carles
Suárez, Ana
Martín-Ventura, José Luis
author_sort Rodríguez-Carrio, Javier
collection PubMed
description High-density lipoproteins cholesterol (HDLc) levels are decreased in abdominal aortic aneurysm (AAA), which is hallmarked by autoimmunity and lipid aortic deposits. To investigate whether IgG anti-HDL antibodies were present in AAA and their potential association with clinical features, IgG anti-HDL and total IgG along with HDLc plasma levels were measured in 488 AAA patients and 184 controls from the Viborg Vascular (VIVA) study, and in tissue-conditioned media from AAA intraluminal thrombus and media layer samples compared to control aortas. Higher IgG anti-HDL levels were found in AAA compared to controls, even after correcting for total IgG, and after adjusting for potential confounders. IgG anti-HDL levels were correlated with aortic diameter in univariate and adjusted multivariate analyses. IgG anti-HDL antibodies were negatively associated with HDLc levels before and after correcting for potential confounders. Increased anti-HDL antibodies were identified in tissue-conditioned media from AAA samples compared to healthy aortas, with higher levels being observed in the media layer. In conclusion, increased IgG anti-HDL levels (both in plasma and in tissue) are linked to AAA, associated with aortic diameter and HDLc levels. These data suggest a potential immune response against HDL in AAA and support an emerging role of anti-HDL antibodies in AAA.
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spelling pubmed-70198332020-03-09 IgG Anti-High Density Lipoprotein Antibodies Are Elevated in Abdominal Aortic Aneurysm and Associated with Lipid Profile and Clinical Features Rodríguez-Carrio, Javier Lindholt, Jes S. Canyelles, Marina Martínez-López, Diego Tondo, Mireia Blanco-Colio, Luis M. Michel, Jean-Baptiste Escolà-Gil, Joan Carles Suárez, Ana Martín-Ventura, José Luis J Clin Med Article High-density lipoproteins cholesterol (HDLc) levels are decreased in abdominal aortic aneurysm (AAA), which is hallmarked by autoimmunity and lipid aortic deposits. To investigate whether IgG anti-HDL antibodies were present in AAA and their potential association with clinical features, IgG anti-HDL and total IgG along with HDLc plasma levels were measured in 488 AAA patients and 184 controls from the Viborg Vascular (VIVA) study, and in tissue-conditioned media from AAA intraluminal thrombus and media layer samples compared to control aortas. Higher IgG anti-HDL levels were found in AAA compared to controls, even after correcting for total IgG, and after adjusting for potential confounders. IgG anti-HDL levels were correlated with aortic diameter in univariate and adjusted multivariate analyses. IgG anti-HDL antibodies were negatively associated with HDLc levels before and after correcting for potential confounders. Increased anti-HDL antibodies were identified in tissue-conditioned media from AAA samples compared to healthy aortas, with higher levels being observed in the media layer. In conclusion, increased IgG anti-HDL levels (both in plasma and in tissue) are linked to AAA, associated with aortic diameter and HDLc levels. These data suggest a potential immune response against HDL in AAA and support an emerging role of anti-HDL antibodies in AAA. MDPI 2019-12-26 /pmc/articles/PMC7019833/ /pubmed/31888089 http://dx.doi.org/10.3390/jcm9010067 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rodríguez-Carrio, Javier
Lindholt, Jes S.
Canyelles, Marina
Martínez-López, Diego
Tondo, Mireia
Blanco-Colio, Luis M.
Michel, Jean-Baptiste
Escolà-Gil, Joan Carles
Suárez, Ana
Martín-Ventura, José Luis
IgG Anti-High Density Lipoprotein Antibodies Are Elevated in Abdominal Aortic Aneurysm and Associated with Lipid Profile and Clinical Features
title IgG Anti-High Density Lipoprotein Antibodies Are Elevated in Abdominal Aortic Aneurysm and Associated with Lipid Profile and Clinical Features
title_full IgG Anti-High Density Lipoprotein Antibodies Are Elevated in Abdominal Aortic Aneurysm and Associated with Lipid Profile and Clinical Features
title_fullStr IgG Anti-High Density Lipoprotein Antibodies Are Elevated in Abdominal Aortic Aneurysm and Associated with Lipid Profile and Clinical Features
title_full_unstemmed IgG Anti-High Density Lipoprotein Antibodies Are Elevated in Abdominal Aortic Aneurysm and Associated with Lipid Profile and Clinical Features
title_short IgG Anti-High Density Lipoprotein Antibodies Are Elevated in Abdominal Aortic Aneurysm and Associated with Lipid Profile and Clinical Features
title_sort igg anti-high density lipoprotein antibodies are elevated in abdominal aortic aneurysm and associated with lipid profile and clinical features
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019833/
https://www.ncbi.nlm.nih.gov/pubmed/31888089
http://dx.doi.org/10.3390/jcm9010067
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