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Systematic Evaluation of Systemic Right Ventricular Function

Background: The right ventricle serves as the subaortic systemic ventricle (sysRV) in patients with congenitally corrected transposition of the great arteries (ccTGA) and in patients with transposition of the great arteries (TGA) surgically repaired by an atrial switch. SysRV can lead to late compli...

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Autores principales: Schneider, Matthias, Beichl, Matthias, Nietsche, Christian, Beitzke, Dietrich, Porenta, Gerold, Beran, Gilbert, Vonbank, Karin, Hauser, Jakob, Hengstenberg, Christian, Goliasch, Georg, Binder, Thomas, Gabriel, Harald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019841/
https://www.ncbi.nlm.nih.gov/pubmed/31906129
http://dx.doi.org/10.3390/jcm9010107
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author Schneider, Matthias
Beichl, Matthias
Nietsche, Christian
Beitzke, Dietrich
Porenta, Gerold
Beran, Gilbert
Vonbank, Karin
Hauser, Jakob
Hengstenberg, Christian
Goliasch, Georg
Binder, Thomas
Gabriel, Harald
author_facet Schneider, Matthias
Beichl, Matthias
Nietsche, Christian
Beitzke, Dietrich
Porenta, Gerold
Beran, Gilbert
Vonbank, Karin
Hauser, Jakob
Hengstenberg, Christian
Goliasch, Georg
Binder, Thomas
Gabriel, Harald
author_sort Schneider, Matthias
collection PubMed
description Background: The right ventricle serves as the subaortic systemic ventricle (sysRV) in patients with congenitally corrected transposition of the great arteries (ccTGA) and in patients with transposition of the great arteries (TGA) surgically repaired by an atrial switch. SysRV can lead to late complications, primarily heart failure, significant regurgitation of the systemic atrioventricular (AV) valve, and ventricular arrhythmias with sudden cardiac death. We sought to investigate the value of 2D- and 3D-echocardiographic parameters of sysRV function. Methods: Consecutive adult patients with sysRV who presented at the adult congenital heart disease outpatient clinic were prospectively enrolled. All patients received comprehensive transthoracic echocardiography, including 3D-echocardiography, cardiac magnetic-resonance-imaging (CMR), cardiopulmonary-exercise-testing, and blood analysis for NT-proBNP. Results. A total of 27 patients were included, 18 with TGA and nine with ccTGA. Median age was 37 years (Q1 = 31, Q3 = 44), 44% were male, median NT-proBNP was 189 pg/mL (Q1 = 155, Q3 = 467); sufficient 3D-echocardiography datasets were acquired in 78% of patients. All echocardiographic 2D and 3D volumetric function parameters correlated with CMR data, whereas a correlation was not seen with any of the longitudinal function parameters. NT-proBNP correlated with tricuspid annular plane systolic excursion (r = −0.43, p = 0.02) and CMR ejection fraction (EF) (r = −0.62, p = 0.003). Conclusion: Systematic evaluation of sysRV is complex and should include not only volumetric parameters but also parameters of longitudinal function in addition to measurement of NT-proBNP. In patients with good image quality, 3D-echocardiography can be used to assess volumes and EF.
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spelling pubmed-70198412020-03-09 Systematic Evaluation of Systemic Right Ventricular Function Schneider, Matthias Beichl, Matthias Nietsche, Christian Beitzke, Dietrich Porenta, Gerold Beran, Gilbert Vonbank, Karin Hauser, Jakob Hengstenberg, Christian Goliasch, Georg Binder, Thomas Gabriel, Harald J Clin Med Article Background: The right ventricle serves as the subaortic systemic ventricle (sysRV) in patients with congenitally corrected transposition of the great arteries (ccTGA) and in patients with transposition of the great arteries (TGA) surgically repaired by an atrial switch. SysRV can lead to late complications, primarily heart failure, significant regurgitation of the systemic atrioventricular (AV) valve, and ventricular arrhythmias with sudden cardiac death. We sought to investigate the value of 2D- and 3D-echocardiographic parameters of sysRV function. Methods: Consecutive adult patients with sysRV who presented at the adult congenital heart disease outpatient clinic were prospectively enrolled. All patients received comprehensive transthoracic echocardiography, including 3D-echocardiography, cardiac magnetic-resonance-imaging (CMR), cardiopulmonary-exercise-testing, and blood analysis for NT-proBNP. Results. A total of 27 patients were included, 18 with TGA and nine with ccTGA. Median age was 37 years (Q1 = 31, Q3 = 44), 44% were male, median NT-proBNP was 189 pg/mL (Q1 = 155, Q3 = 467); sufficient 3D-echocardiography datasets were acquired in 78% of patients. All echocardiographic 2D and 3D volumetric function parameters correlated with CMR data, whereas a correlation was not seen with any of the longitudinal function parameters. NT-proBNP correlated with tricuspid annular plane systolic excursion (r = −0.43, p = 0.02) and CMR ejection fraction (EF) (r = −0.62, p = 0.003). Conclusion: Systematic evaluation of sysRV is complex and should include not only volumetric parameters but also parameters of longitudinal function in addition to measurement of NT-proBNP. In patients with good image quality, 3D-echocardiography can be used to assess volumes and EF. MDPI 2019-12-31 /pmc/articles/PMC7019841/ /pubmed/31906129 http://dx.doi.org/10.3390/jcm9010107 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Schneider, Matthias
Beichl, Matthias
Nietsche, Christian
Beitzke, Dietrich
Porenta, Gerold
Beran, Gilbert
Vonbank, Karin
Hauser, Jakob
Hengstenberg, Christian
Goliasch, Georg
Binder, Thomas
Gabriel, Harald
Systematic Evaluation of Systemic Right Ventricular Function
title Systematic Evaluation of Systemic Right Ventricular Function
title_full Systematic Evaluation of Systemic Right Ventricular Function
title_fullStr Systematic Evaluation of Systemic Right Ventricular Function
title_full_unstemmed Systematic Evaluation of Systemic Right Ventricular Function
title_short Systematic Evaluation of Systemic Right Ventricular Function
title_sort systematic evaluation of systemic right ventricular function
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019841/
https://www.ncbi.nlm.nih.gov/pubmed/31906129
http://dx.doi.org/10.3390/jcm9010107
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