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Tachykinins and Kisspeptins in the Regulation of Human Male Fertility
Infertility is a global disease affecting one out of six couples of reproductive age in the world, with a male factor involved in half the cases. There is still much to know about the regulation of human male fertility and thus we decided to focus on two peptide families that seem to play a key role...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019842/ https://www.ncbi.nlm.nih.gov/pubmed/31906206 http://dx.doi.org/10.3390/jcm9010113 |
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author | Blasco, Víctor Pinto, Francisco M. González-Ravina, Cristina Santamaría-López, Esther Candenas, Luz Fernández-Sánchez, Manuel |
author_facet | Blasco, Víctor Pinto, Francisco M. González-Ravina, Cristina Santamaría-López, Esther Candenas, Luz Fernández-Sánchez, Manuel |
author_sort | Blasco, Víctor |
collection | PubMed |
description | Infertility is a global disease affecting one out of six couples of reproductive age in the world, with a male factor involved in half the cases. There is still much to know about the regulation of human male fertility and thus we decided to focus on two peptide families that seem to play a key role in this function: tachykinins and kisspeptins. With this aim, we conducted an exhaustive review in order to describe the role of tachykinins and kisspeptins in human fertility and their possible implications in infertility etiopathogenesis. Many advances have been made to elucidate the roles of these two families in infertility, and multiple animal species have been studied, including humans. All of this knowledge could lead to new advances in male infertility diagnosis and treatment, but further research is needed to clarify all the implications of tachykinins and kisspeptins in fertility. |
format | Online Article Text |
id | pubmed-7019842 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-70198422020-03-09 Tachykinins and Kisspeptins in the Regulation of Human Male Fertility Blasco, Víctor Pinto, Francisco M. González-Ravina, Cristina Santamaría-López, Esther Candenas, Luz Fernández-Sánchez, Manuel J Clin Med Review Infertility is a global disease affecting one out of six couples of reproductive age in the world, with a male factor involved in half the cases. There is still much to know about the regulation of human male fertility and thus we decided to focus on two peptide families that seem to play a key role in this function: tachykinins and kisspeptins. With this aim, we conducted an exhaustive review in order to describe the role of tachykinins and kisspeptins in human fertility and their possible implications in infertility etiopathogenesis. Many advances have been made to elucidate the roles of these two families in infertility, and multiple animal species have been studied, including humans. All of this knowledge could lead to new advances in male infertility diagnosis and treatment, but further research is needed to clarify all the implications of tachykinins and kisspeptins in fertility. MDPI 2019-12-31 /pmc/articles/PMC7019842/ /pubmed/31906206 http://dx.doi.org/10.3390/jcm9010113 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Blasco, Víctor Pinto, Francisco M. González-Ravina, Cristina Santamaría-López, Esther Candenas, Luz Fernández-Sánchez, Manuel Tachykinins and Kisspeptins in the Regulation of Human Male Fertility |
title | Tachykinins and Kisspeptins in the Regulation of Human Male Fertility |
title_full | Tachykinins and Kisspeptins in the Regulation of Human Male Fertility |
title_fullStr | Tachykinins and Kisspeptins in the Regulation of Human Male Fertility |
title_full_unstemmed | Tachykinins and Kisspeptins in the Regulation of Human Male Fertility |
title_short | Tachykinins and Kisspeptins in the Regulation of Human Male Fertility |
title_sort | tachykinins and kisspeptins in the regulation of human male fertility |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019842/ https://www.ncbi.nlm.nih.gov/pubmed/31906206 http://dx.doi.org/10.3390/jcm9010113 |
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