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Pain Severity and Vitamin D Deficiency in IBD Patients

Background: Pain and vitamin D deficiency are common in inflammatory bowel disease (IBD). Disease activity, fatigue, frequent relapses, prior surgery and psychological factors all seem to influence the experience of pain in IBD. Vitamin D deficiency has been associated with muscle and skeletal pain....

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Autores principales: Frigstad, Svein Oskar, Høivik, Marte Lie, Jahnsen, Jørgen, Cvancarova, Milada, Grimstad, Tore, Berset, Ingrid Prytz, Huppertz-Hauss, Gert, Hovde, Øistein, Bernklev, Tomm, Moum, Bjørn, Jelsness-Jørgensen, Lars-Petter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019855/
https://www.ncbi.nlm.nih.gov/pubmed/31877637
http://dx.doi.org/10.3390/nu12010026
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author Frigstad, Svein Oskar
Høivik, Marte Lie
Jahnsen, Jørgen
Cvancarova, Milada
Grimstad, Tore
Berset, Ingrid Prytz
Huppertz-Hauss, Gert
Hovde, Øistein
Bernklev, Tomm
Moum, Bjørn
Jelsness-Jørgensen, Lars-Petter
author_facet Frigstad, Svein Oskar
Høivik, Marte Lie
Jahnsen, Jørgen
Cvancarova, Milada
Grimstad, Tore
Berset, Ingrid Prytz
Huppertz-Hauss, Gert
Hovde, Øistein
Bernklev, Tomm
Moum, Bjørn
Jelsness-Jørgensen, Lars-Petter
author_sort Frigstad, Svein Oskar
collection PubMed
description Background: Pain and vitamin D deficiency are common in inflammatory bowel disease (IBD). Disease activity, fatigue, frequent relapses, prior surgery and psychological factors all seem to influence the experience of pain in IBD. Vitamin D deficiency has been associated with muscle and skeletal pain. This study aimed to determine whether there is an association between vitamin D deficiency and severity of pain in patients with IBD, and to investigate the influence of other socio-demographic and psychological variables on the experience of pain. Methods: Patients with IBD were recruited from nine hospitals in Norway in a multicenter cross-sectional study. The Brief Pain Inventory (BPI) questionnaire was used to measure pain. Disease activity was assessed using clinical disease activity indices, C-reactive protein (CRP) and fecal calprotectin. Regression models were fitted to explore a possible association between 25-hydroxyvitamin D and pain severity. Results: Of 407 patients included in the analyses, 229 (56%) had Crohn’s disease (CD) and 178 (44%) had ulcerative colitis (UC). Vitamin D deficiency was present in half (203/407) of patients. Presence of pain was reported by 76% (309/407). More severe pain was associated with female gender and increased disease activity scores, but not with increased CRP or fecal calprotectin. In CD, patients without prior intra-abdominal surgery reported more severe pain. In multivariate analyses, there was no association between 25-hydroxyvitamin D and pain severity. Conclusions: In this study, no significant association between pain severity and vitamin D deficiency was revealed in patients with IBD.
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spelling pubmed-70198552020-03-09 Pain Severity and Vitamin D Deficiency in IBD Patients Frigstad, Svein Oskar Høivik, Marte Lie Jahnsen, Jørgen Cvancarova, Milada Grimstad, Tore Berset, Ingrid Prytz Huppertz-Hauss, Gert Hovde, Øistein Bernklev, Tomm Moum, Bjørn Jelsness-Jørgensen, Lars-Petter Nutrients Article Background: Pain and vitamin D deficiency are common in inflammatory bowel disease (IBD). Disease activity, fatigue, frequent relapses, prior surgery and psychological factors all seem to influence the experience of pain in IBD. Vitamin D deficiency has been associated with muscle and skeletal pain. This study aimed to determine whether there is an association between vitamin D deficiency and severity of pain in patients with IBD, and to investigate the influence of other socio-demographic and psychological variables on the experience of pain. Methods: Patients with IBD were recruited from nine hospitals in Norway in a multicenter cross-sectional study. The Brief Pain Inventory (BPI) questionnaire was used to measure pain. Disease activity was assessed using clinical disease activity indices, C-reactive protein (CRP) and fecal calprotectin. Regression models were fitted to explore a possible association between 25-hydroxyvitamin D and pain severity. Results: Of 407 patients included in the analyses, 229 (56%) had Crohn’s disease (CD) and 178 (44%) had ulcerative colitis (UC). Vitamin D deficiency was present in half (203/407) of patients. Presence of pain was reported by 76% (309/407). More severe pain was associated with female gender and increased disease activity scores, but not with increased CRP or fecal calprotectin. In CD, patients without prior intra-abdominal surgery reported more severe pain. In multivariate analyses, there was no association between 25-hydroxyvitamin D and pain severity. Conclusions: In this study, no significant association between pain severity and vitamin D deficiency was revealed in patients with IBD. MDPI 2019-12-20 /pmc/articles/PMC7019855/ /pubmed/31877637 http://dx.doi.org/10.3390/nu12010026 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Frigstad, Svein Oskar
Høivik, Marte Lie
Jahnsen, Jørgen
Cvancarova, Milada
Grimstad, Tore
Berset, Ingrid Prytz
Huppertz-Hauss, Gert
Hovde, Øistein
Bernklev, Tomm
Moum, Bjørn
Jelsness-Jørgensen, Lars-Petter
Pain Severity and Vitamin D Deficiency in IBD Patients
title Pain Severity and Vitamin D Deficiency in IBD Patients
title_full Pain Severity and Vitamin D Deficiency in IBD Patients
title_fullStr Pain Severity and Vitamin D Deficiency in IBD Patients
title_full_unstemmed Pain Severity and Vitamin D Deficiency in IBD Patients
title_short Pain Severity and Vitamin D Deficiency in IBD Patients
title_sort pain severity and vitamin d deficiency in ibd patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019855/
https://www.ncbi.nlm.nih.gov/pubmed/31877637
http://dx.doi.org/10.3390/nu12010026
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