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A Polymorphism in the Catalase Gene Promoter Confers Protection against Severe RSV Bronchiolitis
Respiratory syncytial virus (RSV) infection is associated with oxidative lung injury, decreased levels of antioxidant enzymes (AOEs), and the degradation of the transcription factor NF-E2-related factor 2 (NRF2), a master regulator of AOE expression. Single nucleotide polymorphisms (SNPs) in AOE and...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019864/ https://www.ncbi.nlm.nih.gov/pubmed/31947722 http://dx.doi.org/10.3390/v12010057 |
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author | Chambliss, Jeffrey M. Ansar, Maria Kelley, John P. Spratt, Heidi Garofalo, Roberto P. Casola, Antonella |
author_facet | Chambliss, Jeffrey M. Ansar, Maria Kelley, John P. Spratt, Heidi Garofalo, Roberto P. Casola, Antonella |
author_sort | Chambliss, Jeffrey M. |
collection | PubMed |
description | Respiratory syncytial virus (RSV) infection is associated with oxidative lung injury, decreased levels of antioxidant enzymes (AOEs), and the degradation of the transcription factor NF-E2-related factor 2 (NRF2), a master regulator of AOE expression. Single nucleotide polymorphisms (SNPs) in AOE and NRF2 genes have been associated with various lung disorders. To test whether specific NRF2 and/or AOE gene SNPs in children with RSV lower respiratory tract infection were associated with disease severity, one hundred and forty one children <24 month of age with bronchiolitis were assessed for seven AOE and two NRF2 SNPs, and data were correlated with disease severity, which was determined by need of oxygen supplementation and intensive care support. One SNP in the promoter region of the catalase gene, rs1001179, which is associated with higher enzyme expression, was significantly underrepresented (p = 0.01, OR 0.38) among patients with moderate to severe RSV bronchiolitis, suggesting a protective effect against disease severity. Our results suggest that increasing catalase expression/activity could exert a protective role in the context of RSV infection and represent a potential novel therapeutic target to ameliorate viral-induced lung disease. |
format | Online Article Text |
id | pubmed-7019864 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-70198642020-03-09 A Polymorphism in the Catalase Gene Promoter Confers Protection against Severe RSV Bronchiolitis Chambliss, Jeffrey M. Ansar, Maria Kelley, John P. Spratt, Heidi Garofalo, Roberto P. Casola, Antonella Viruses Article Respiratory syncytial virus (RSV) infection is associated with oxidative lung injury, decreased levels of antioxidant enzymes (AOEs), and the degradation of the transcription factor NF-E2-related factor 2 (NRF2), a master regulator of AOE expression. Single nucleotide polymorphisms (SNPs) in AOE and NRF2 genes have been associated with various lung disorders. To test whether specific NRF2 and/or AOE gene SNPs in children with RSV lower respiratory tract infection were associated with disease severity, one hundred and forty one children <24 month of age with bronchiolitis were assessed for seven AOE and two NRF2 SNPs, and data were correlated with disease severity, which was determined by need of oxygen supplementation and intensive care support. One SNP in the promoter region of the catalase gene, rs1001179, which is associated with higher enzyme expression, was significantly underrepresented (p = 0.01, OR 0.38) among patients with moderate to severe RSV bronchiolitis, suggesting a protective effect against disease severity. Our results suggest that increasing catalase expression/activity could exert a protective role in the context of RSV infection and represent a potential novel therapeutic target to ameliorate viral-induced lung disease. MDPI 2020-01-03 /pmc/articles/PMC7019864/ /pubmed/31947722 http://dx.doi.org/10.3390/v12010057 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Chambliss, Jeffrey M. Ansar, Maria Kelley, John P. Spratt, Heidi Garofalo, Roberto P. Casola, Antonella A Polymorphism in the Catalase Gene Promoter Confers Protection against Severe RSV Bronchiolitis |
title | A Polymorphism in the Catalase Gene Promoter Confers Protection against Severe RSV Bronchiolitis |
title_full | A Polymorphism in the Catalase Gene Promoter Confers Protection against Severe RSV Bronchiolitis |
title_fullStr | A Polymorphism in the Catalase Gene Promoter Confers Protection against Severe RSV Bronchiolitis |
title_full_unstemmed | A Polymorphism in the Catalase Gene Promoter Confers Protection against Severe RSV Bronchiolitis |
title_short | A Polymorphism in the Catalase Gene Promoter Confers Protection against Severe RSV Bronchiolitis |
title_sort | polymorphism in the catalase gene promoter confers protection against severe rsv bronchiolitis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019864/ https://www.ncbi.nlm.nih.gov/pubmed/31947722 http://dx.doi.org/10.3390/v12010057 |
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